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Presence of Peripheral Neuropathy Is Associated With Progressive Thinning of Retinal Nerve Fiber Layer in Type 1 Diabetes.

Abstract Reduced retinal nerve fiber layer (RNFL) thickness has been demonstrated in patients with diabetic peripheral neuropathy (DPN) in cross-sectional studies. This prospective study defines longitudinal alterations to the RNFL thickness in individuals with type 1 diabetes without (DPN-ve) and with (DPN+ve) DPN and in relation to risk factors for nerve damage.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28828484
OWN - NLM
STAT- MEDLINE
DA  - 20170822
DCOM- 20170901
LR  - 20170901
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 6
DP  - 2017 May 01
TI  - Presence of Peripheral Neuropathy Is Associated With Progressive Thinning of
      Retinal Nerve Fiber Layer in Type 1 Diabetes.
PG  - BIO234-BIO239
LID - 10.1167/iovs.17-21801 [doi]
AB  - Purpose: Reduced retinal nerve fiber layer (RNFL) thickness has been demonstrated
      in patients with diabetic peripheral neuropathy (DPN) in cross-sectional studies.
      This prospective study defines longitudinal alterations to the RNFL thickness in 
      individuals with type 1 diabetes without (DPN-ve) and with (DPN+ve) DPN and in
      relation to risk factors for nerve damage. Methods: A cohort of 105 individuals
      with type 1 diabetes (20% DPN+ve) with predominantly mild or no retinopathy and
      no previous retinal photocoagulation underwent spectral-domain optical coherence 
      tomography (SD-OCT) at baseline, 2 years, and 4 years. SD-OCT scans were acquired
      at 3.45-mm diameter around the optic nerve head and the overall RNFL and RNFL in 
      the nasal, superior, temporal, and inferior quadrants were quantified. By
      including serial quantified RNFL parameters, linear mixed models were applied to 
      assess the change in RNFL thickness over time and to explore the associations
      with other clinical variables. Results: There was a significant decline in the
      overall RNFL thickness (-0.7 mum/y, P = 0.02) and RNFL in the superior quadrant
      (-1.9 mum/y, P < 0.01) in the DPN+ve group compared with DPN-ve group. The
      overall RNFL thickness and RNFL in the superior and nasal quadrants were
      inversely associated with age (beta = -0.29, -0.41, and -0.29, respectively; P
      </= 0.02). Sex, retinopathy, diabetes duration, hemoglobin A1c, lipid profile,
      blood pressure, cigarette use, alcohol consumption, and body mass index did not
      show any significant effects (P > 0.05). Conclusions: Individuals with DPN showed
      a progressive RNFL thinning overall and in the superior quadrant, which was more 
      pronounced in older individuals. There may be common pathways for retinal and
      peripheral neurodegeneration that are independent of conventional DPN risk
      factors.
FAU - Dehghani, Cirous
AU  - Dehghani C
AD  - Institute of Health & Biomedical Innovation, and School of Optometry and Vision
      Science, Queensland University of Technology, Australia.
AD  - Commonwealth Scientific and Industrial Research Organisation (CSIRO), Parkville, 
      Victoria, Australia.
AD  - Poostchi Eye Research Center, Department of Ophthalmology, School of Medicine,
      Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Srinivasan, Sangeetha
AU  - Srinivasan S
AD  - Institute of Health & Biomedical Innovation, and School of Optometry and Vision
      Science, Queensland University of Technology, Australia.
FAU - Edwards, Katie
AU  - Edwards K
AD  - Institute of Health & Biomedical Innovation, and School of Optometry and Vision
      Science, Queensland University of Technology, Australia.
FAU - Pritchard, Nicola
AU  - Pritchard N
AD  - Institute of Health & Biomedical Innovation, and School of Optometry and Vision
      Science, Queensland University of Technology, Australia.
FAU - Russell, Anthony W
AU  - Russell AW
AD  - Department of Diabetes and Endocrinology, Princess Alexandra Hospital, and School
      of Medicine, University of Queensland, Queensland, Australia.
FAU - Malik, Rayaz A
AU  - Malik RA
AD  - Institute of Cardiovascular Science, University of Manchester, Manchester, United
      Kingdom.
AD  - Weill Cornell Medicine - Qatar, Doha, Qatar.
FAU - Efron, Nathan
AU  - Efron N
AD  - Institute of Health & Biomedical Innovation, and School of Optometry and Vision
      Science, Queensland University of Technology, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*complications/diagnosis
MH  - Diabetic Neuropathies/etiology/*pathology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Risk Factors
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
EDAT- 2017/08/23 06:00
MHDA- 2017/09/02 06:00
CRDT- 2017/08/23 06:00
AID - 2650854 [pii]
AID - 10.1167/iovs.17-21801 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO234-BIO239. doi:
      10.1167/iovs.17-21801.