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Case Report: Severe and Complicated Cynomolgi Malaria in a Rhesus Macaque Resulted in Similar Histopathological Changes as Those Seen in Human Malaria.

Abstract Histopathological data collected from patients with severe malaria have been instrumental for studying malaria pathogenesis. Animal models of malaria are critical to complement such studies. Here, the histopathological changes observed in a rhesus macaque with severe and complicated Plasmodium cynomolgi malaria are reported. The animal presented with thrombocytopenia, severe anemia, and hyperparasitemia during the acute infection. The macaque was given subcurative antimalarial treatment, fluid support, and a blood transfusion to treat the clinical complications, but at the time of transfusion, kidney function was compromised. These interventions did not restore kidney function, and the animal was euthanized due to irreversible renal failure. Gross pathological and histological examinations revealed that the lungs, kidneys, liver, spleen, and bone marrow exhibited abnormalities similar to those described in patients with malaria. Overall, this case report illustrates the similarities in the pathophysiological complications that can occur in human malaria and cynomolgi malaria in rhesus macaques.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the american journal of tropical medicine and hygiene
Publication Year Start




PMID- 28829738
OWN - NLM
STAT- MEDLINE
DA  - 20170822
DCOM- 20170911
LR  - 20170911
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Linking)
VI  - 97
IP  - 2
DP  - 2017 Aug
TI  - Case Report: Severe and Complicated Cynomolgi Malaria in a Rhesus Macaque
      Resulted in Similar Histopathological Changes as Those Seen in Human Malaria.
PG  - 548-555
LID - 10.4269/ajtmh.16-0742 [doi]
AB  - Histopathological data collected from patients with severe malaria have been
      instrumental for studying malaria pathogenesis. Animal models of malaria are
      critical to complement such studies. Here, the histopathological changes observed
      in a rhesus macaque with severe and complicated Plasmodium cynomolgi malaria are 
      reported. The animal presented with thrombocytopenia, severe anemia, and
      hyperparasitemia during the acute infection. The macaque was given subcurative
      antimalarial treatment, fluid support, and a blood transfusion to treat the
      clinical complications, but at the time of transfusion, kidney function was
      compromised. These interventions did not restore kidney function, and the animal 
      was euthanized due to irreversible renal failure. Gross pathological and
      histological examinations revealed that the lungs, kidneys, liver, spleen, and
      bone marrow exhibited abnormalities similar to those described in patients with
      malaria. Overall, this case report illustrates the similarities in the
      pathophysiological complications that can occur in human malaria and cynomolgi
      malaria in rhesus macaques.
FAU - J Joyner, Chester
AU  - J Joyner C
AD  - Malaria Host-Pathogen Interaction Center, Emory Vaccine Center, Yerkes National
      Primate Research Center, Emory University, Atlanta, Georgia.
FAU - Consortium, The MaHPIC
AU  - Consortium TM
AD  - Malaria Host-Pathogen Interaction Center, Emory Vaccine Center, Yerkes National
      Primate Research Center, Emory University, Atlanta, Georgia.
FAU - Wood, Jennifer S
AU  - Wood JS
AD  - Division of Animal Resources, Yerkes National Primate Research Center, Emory
      University, Atlanta, Georgia.
FAU - Moreno, Alberto
AU  - Moreno A
AD  - Division of Infectious Diseases, Department of Medicine, Emory University,
      Atlanta, Georgia.
AD  - Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 
      Atlanta, Georgia.
AD  - Malaria Host-Pathogen Interaction Center, Emory Vaccine Center, Yerkes National
      Primate Research Center, Emory University, Atlanta, Georgia.
FAU - Garcia, Anapatricia
AU  - Garcia A
AD  - Division of Pathology, Yerkes National Primate Research Center, Emory University,
      Atlanta, Georgia.
FAU - Galinski, Mary R
AU  - Galinski MR
AD  - Malaria Host-Pathogen Interaction Center, Emory Vaccine Center, Yerkes National
      Primate Research Center, Emory University, Atlanta, Georgia.
AD  - Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 
      Atlanta, Georgia.
AD  - Division of Infectious Diseases, Department of Medicine, Emory University,
      Atlanta, Georgia.
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
SB  - AIM
SB  - IM
MH  - Animals
MH  - Bone Marrow/anatomy & histology
MH  - Disease Models, Animal
MH  - Humans
MH  - Kidney/cytology
MH  - Liver/cytology
MH  - Lung/cytology
MH  - Macaca mulatta/*parasitology
MH  - Malaria/*complications/*parasitology/pathology
MH  - Plasmodium cynomolgi/*isolation & purification/*parasitology/*pathogenicity
MH  - Spleen/cytology
EDAT- 2017/08/23 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/08/23 06:00
AID - 10.4269/ajtmh.16-0742 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2017 Aug;97(2):548-555. doi: 10.4269/ajtmh.16-0742.