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Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure.

Abstract We used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG).
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28829843
OWN - NLM
STAT- MEDLINE
DA  - 20170822
DCOM- 20170828
LR  - 20170828
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary
      Open-Angle Glaucoma With Normal Intraocular Pressure.
PG  - 4114-4125
LID - 10.1167/iovs.17-22093 [doi]
AB  - Purpose: We used magnetic resonance imaging (MRI) to ascertain effects of optic
      nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary
      open-angle glaucoma (POAG). Methods: Seventeen patients with POAG and maximal IOP
      </= 20 mm Hg, and 31 controls underwent MRI in central gaze and 20 degrees to 30 
      degrees abduction and adduction. Optic nerve and sheath area centroids permitted 
      computation of midorbital lengths versus minimum paths. Results: Average mean
      deviation (+/-SEM) was -8.2 +/- 1.2 dB in the 15 patients with POAG having
      interpretable perimetry. In central gaze, ON path length in POAG was
      significantly more redundant (104.5 +/- 0.4% of geometric minimum) than in
      controls (102.9 +/- 0.4%, P = 2.96 x 10-4). In both groups the ON became
      significantly straighter in adduction (28.6 +/- 0.8 degrees in POAG, 26.8 +/- 1.1
      degrees in controls) than central gaze and abduction. In adduction, the ON in
      POAG straightened to 102.0% +/- 0.2% of minimum path length versus 104.5% +/-
      0.4% in central gaze (P = 5.7 x 10-7), compared with controls who straightened to
      101.6% +/- 0.1% from 102.9% +/- 0.3% in central gaze (P = 8.7 x 10-6); and globes
      retracted 0.73 +/- 0.09 mm in POAG, but only 0.07 +/- 0.08 mm in controls (P =
      8.8 x 10-7). Both effects were confirmed in age-matched controls, and remained
      significant after correction for significant effects of age and axial globe
      length (P = 0.005). Conclusions: Although tethering and elongation of ON and
      sheath are normal in adduction, adduction is associated with abnormally great
      globe retraction in POAG without elevated IOP. Traction in adduction may cause
      mechanical overloading of the ON head and peripapillary sclera, thus contributing
      to or resulting from the optic neuropathy of glaucoma independent of IOP.
FAU - Demer, Joseph L
AU  - Demer JL
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
AD  - Stein Eye Institute, University of California, Los Angeles, California, United
      States.
AD  - Biomedical Engineering Interdepartmental Program, University of California, Los
      Angeles, California, United States.
AD  - Neuroscience Interdepartmental Program, University of California, Los Angeles,
      California, United States.
AD  - Department of Neurology, University of California, Los Angeles, California,
      United States.
FAU - Clark, Robert A
AU  - Clark RA
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
AD  - Stein Eye Institute, University of California, Los Angeles, California, United
      States.
FAU - Suh, Soh Youn
AU  - Suh SY
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
FAU - Giaconi, JoAnn A
AU  - Giaconi JA
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
AD  - Stein Eye Institute, University of California, Los Angeles, California, United
      States.
FAU - Nouri-Mahdavi, Kouros
AU  - Nouri-Mahdavi K
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
AD  - Stein Eye Institute, University of California, Los Angeles, California, United
      States.
FAU - Law, Simon K
AU  - Law SK
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
AD  - Stein Eye Institute, University of California, Los Angeles, California, United
      States.
FAU - Bonelli, Laura
AU  - Bonelli L
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
AD  - Stein Eye Institute, University of California, Los Angeles, California, United
      States.
FAU - Coleman, Anne L
AU  - Coleman AL
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
AD  - Stein Eye Institute, University of California, Los Angeles, California, United
      States.
FAU - Caprioli, Joseph
AU  - Caprioli J
AD  - Department of Ophthalmology, University of California, Los Angeles, California,
      United States.
AD  - Stein Eye Institute, University of California, Los Angeles, California, United
      States.
LA  - eng
GR  - P30 EY000331/EY/NEI NIH HHS/United States
GR  - R01 EY008313/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - Glaucoma, Primary Open Angle
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Glaucoma, Open-Angle/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Optic Nerve/diagnostic imaging/*physiopathology
MH  - Optic Nerve Diseases/diagnostic imaging/pathology/*physiopathology
MH  - Prospective Studies
MH  - Visual Fields/physiology
MH  - Young Adult
PMC - PMC5566384
EDAT- 2017/08/23 06:00
MHDA- 2017/08/29 06:00
CRDT- 2017/08/23 06:00
AID - 2650855 [pii]
AID - 10.1167/iovs.17-22093 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4114-4125. doi:
      10.1167/iovs.17-22093.