PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

The Charles Bonnet Syndrome in Patients With Neovascular Age-Related Macular Degeneration: Association With Proton Pump Inhibitors.

Abstract We investigate the prevalence of the Charles Bonnet syndrome (CBS) in patients with neovascular age-related macular degeneration (AMD) and analyze the role of oral proton pump inhibitors (PPIs) and other potential risk factors.
PMID
Related Publications

Visual hallucinations and Charles Bonnet syndrome after photodynamic therapy for age related macular degeneration.

What associates Charles Bonnet syndrome with age-related macular degeneration?

Charles Bonnet syndrome in age-related macular degeneration: the nature and frequency of images in subjects with end-stage disease.

Visual loss and visual hallucinations in patients with age-related macular degeneration (Charles Bonnet syndrome).

The prevalence and clinical characteristics of Charles Bonnet Syndrome in Danish patients with neovascular age-related macular degeneration.

Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28829845
OWN - NLM
STAT- MEDLINE
DA  - 20170822
DCOM- 20170828
LR  - 20170828
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - The Charles Bonnet Syndrome in Patients With Neovascular Age-Related Macular
      Degeneration: Association With Proton Pump Inhibitors.
PG  - 4138-4142
LID - 10.1167/iovs.16-21270 [doi]
AB  - Purpose: We investigate the prevalence of the Charles Bonnet syndrome (CBS) in
      patients with neovascular age-related macular degeneration (AMD) and analyze the 
      role of oral proton pump inhibitors (PPIs) and other potential risk factors.
      Methods: A total of 510 consecutive patients with neovascular-AMD followed at a
      single tertiary center in Portugal were screened for CBS. Using a structured
      questionnaire, psychiatrically healthy individuals were interviewed
      systematically and divided into a CBS group and a non-CBS group. Demographic
      data, current medication, and ocular risk factors were collected and compared
      between the two groups. Results: A total of 500 patients met the inclusion
      criteria and 471 with complete data were included in the final analysis. The
      prevalence of CBS was 9.0% (45/500). Using a binary logistic regression model,
      correlations were found between older age (P = 0.002), PPI intake (P = 0.022),
      poor visual acuity (P = 0.004), and development of CBS. PPIs doubled the risk of 
      CBS from 7% (20/304) to 15% (25/167), with an odds ratio of 2.154. The increased 
      risk for visual hallucinations caused by PPIs was independent of age (P = 0.598) 
      and visual acuity (P = 0.739). Conclusions: The prevalence of CBS in
      neovascular-AMD patients is high and mainly affects older individuals with poor
      visual acuity. PPIs seem to increase the risk of development of hallucinations
      independently of the degree of visual loss.
FAU - Leandro, Joao Esteves
AU  - Leandro JE
AD  - Department of Ophthalmology, Sao Joao Hospital, Porto, Portugal.
FAU - Beato, Joao
AU  - Beato J
AD  - Department of Ophthalmology, Sao Joao Hospital, Porto, Portugal.
AD  - Department of Surgery and Physiology, Faculty of Medicine, University of Porto,
      Porto, Portugal.
FAU - Pedrosa, Ana Catarina
AU  - Pedrosa AC
AD  - Department of Ophthalmology, Sao Joao Hospital, Porto, Portugal.
FAU - Pinheiro-Costa, Joao
AU  - Pinheiro-Costa J
AD  - Department of Ophthalmology, Sao Joao Hospital, Porto, Portugal.
AD  - Department of Anatomy, Faculty of Medicine, University of Porto, Porto, Portugal.
FAU - Falcao, Manuel
AU  - Falcao M
AD  - Department of Ophthalmology, Sao Joao Hospital, Porto, Portugal.
AD  - Department of Surgery and Physiology, Faculty of Medicine, University of Porto,
      Porto, Portugal.
FAU - Falcao-Reis, Fernando
AU  - Falcao-Reis F
AD  - Department of Ophthalmology, Sao Joao Hospital, Porto, Portugal.
AD  - Department of Surgery and Physiology, Faculty of Medicine, University of Porto,
      Porto, Portugal.
FAU - Carneiro, Angela M
AU  - Carneiro AM
AD  - Department of Ophthalmology, Sao Joao Hospital, Porto, Portugal.
AD  - Department of Surgery and Physiology, Faculty of Medicine, University of Porto,
      Porto, Portugal.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Hallucinations/chemically induced/*epidemiology/etiology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Portugal/epidemiology
MH  - Prevalence
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Risk Factors
MH  - Syndrome
MH  - Wet Macular Degeneration/*complications
EDAT- 2017/08/23 06:00
MHDA- 2017/08/29 06:00
CRDT- 2017/08/23 06:00
AID - 2650857 [pii]
AID - 10.1167/iovs.16-21270 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4138-4142. doi:
      10.1167/iovs.16-21270.