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In vivo evaluation of hot water extract of Acorus gramineus root against benign prostatic hyperplasia.

Abstract Acorus gramineus has been reported to exhibit various pharmacological effects including inhibition of cholesterol synthesis, enhancement of lipid metabolism, prevention of dementia and inhibition of mast cell growth. According to the Chinese compendium of materia media, it has been reported that Acorus spp. is effective for sedation, dementia prevention as well as diuretic effect. In addition, it showed more than equivalent activity compared to furosoemide, a drug known to be effective in diuretic action in animal model study. However, their effectiveness against benign prostatic hyperplasia (BPH) of Acorus gramineus has not been reported. This study was designed to evaluate the effect of Acorus gramineus root hot water extract (AG) against BPH in vivo.
PMID
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Authors

Mayor MeshTerms

Prostatic Hyperplasia

Keywords

5-α reductase

Acorus gramineus

Anti-oxidant activation androgen receptor

Benign prostatic hyperplasia

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28830494
OWN - NLM
STAT- MEDLINE
DA  - 20170823
DCOM- 20170911
LR  - 20170911
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Aug 22
TI  - In vivo evaluation of hot water extract of Acorus gramineus root against benign
      prostatic hyperplasia.
PG  - 414
LID - 10.1186/s12906-017-1887-9 [doi]
AB  - BACKGROUND: Acorus gramineus has been reported to exhibit various pharmacological
      effects including inhibition of cholesterol synthesis, enhancement of lipid
      metabolism, prevention of dementia and inhibition of mast cell growth. According 
      to the Chinese compendium of materia media, it has been reported that Acorus spp.
      is effective for sedation, dementia prevention as well as diuretic effect. In
      addition, it showed more than equivalent activity compared to furosoemide, a drug
      known to be effective in diuretic action in animal model study. However, their
      effectiveness against benign prostatic hyperplasia (BPH) of Acorus gramineus has 
      not been reported. This study was designed to evaluate the effect of Acorus
      gramineus root hot water extract (AG) against BPH in vivo. METHODS: Male rats, 10
      weeks of age and weighing 405 g +/- 10 g, were used for this study. Biomarkers
      were evaluated including prostate weight, prostate weight ratio, hormonal
      changes, 5-alpha reductase type II androgen receptor (AR) of the prostate gland
      and anti-oxidant activation factors related to BPH. These biomarkers were
      measured in vivo test. RESULTS: AG showed significant effect at the 250 and 500
      mg/kg/day in rats. Groups treated with AG displayed significantly lower levels of
      prostate gland weight (0.79 g) compared to the BPH induced group (1.19 g). Also, 
      dihydrotestosterone (DHT) level was decreased from 61.8 to 100% and androgen
      receptor expression level was decreased from 111 to 658%. Any hematological
      toxicity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST)
      level wasn't observed. CONCLUSION: This study indicated that AG was effective for
      reducing BPH symptoms. TRIAL REGISTRATION: Not applicable.
FAU - Moon, Joo-Myung
AU  - Moon JM
AD  - #913, Technology advancement dong, Gyeonggi Technopark 705 Haean-ro, Sangnok-gu, 
      Ansan-si, Gyeonggi-do, 15588, Republic of Korea.
FAU - Sung, Hae-Mi
AU  - Sung HM
AD  - Food Research Center, Jeonnam Bio-industry Foundation, 30-5
      Dongsunonggongdanji-gil, Naju-si, Jeollanam-do, 58275, Republic of Korea.
FAU - Jung, Hyun-Jung
AU  - Jung HJ
AD  - Food Research Center, Jeonnam Bio-industry Foundation, 30-5
      Dongsunonggongdanji-gil, Naju-si, Jeollanam-do, 58275, Republic of Korea.
FAU - Seo, Jae-Won
AU  - Seo JW
AD  - #913, Technology advancement dong, Gyeonggi Technopark 705 Haean-ro, Sangnok-gu, 
      Ansan-si, Gyeonggi-do, 15588, Republic of Korea.
FAU - Wee, Ji-Hyang
AU  - Wee JH
AD  - Food Research Center, Jeonnam Bio-industry Foundation, 30-5
      Dongsunonggongdanji-gil, Naju-si, Jeollanam-do, 58275, Republic of Korea.
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170822
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 0 (Receptors, Androgen)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - EC 1.3.1.22 (Cholestenone 5 alpha-Reductase)
SB  - IM
MH  - Acorus/*chemistry
MH  - Animals
MH  - Antioxidants/analysis/metabolism
MH  - Cholestenone 5 alpha-Reductase/analysis/genetics/metabolism
MH  - Dihydrotestosterone/analysis/metabolism
MH  - Gene Expression Profiling
MH  - Male
MH  - Organ Size/drug effects
MH  - Plant Extracts/*pharmacology/*therapeutic use
MH  - Prostate/chemistry/*drug effects/enzymology/pathology
MH  - *Prostatic Hyperplasia/drug therapy/genetics/metabolism
MH  - Rats
MH  - Receptors, Androgen/analysis/genetics/metabolism
PMC - PMC5568233
OTO - NOTNLM
OT  - 5-alpha reductase
OT  - Acorus gramineus
OT  - Anti-oxidant activation androgen receptor
OT  - Benign prostatic hyperplasia
EDAT- 2017/08/24 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/08/24 06:00
PHST- 2017/01/11 [received]
PHST- 2017/07/21 [accepted]
AID - 10.1186/s12906-017-1887-9 [doi]
AID - 10.1186/s12906-017-1887-9 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Aug 22;17(1):414. doi: 10.1186/s12906-017-1887-9.