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Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study.

Abstract The aim of this study was to identify the expression of Ki-67 and MCM3 in oral squamous cell carcinoma (OSCC) as well as to address the correlation with patient survival and clinical features. Samples were collected from 51 patients with OSCC who presented for follow-up. Immunohistochemical expression of Ki-67 and MCM3 in all groups was performed. The scoring system was previous published by Tsurutani in 2005. We used Kappa index to evaluate observers agreement degree. The associations between protein expression and clinical variables were examined for statistical significance using the chi-squared test. The overall survival rates were estimated by the Kaplan-Meier method and the relationship between protein expression and survival was compared using the log-rank test (p < 0.05). The overall survival time for a patient with positive immunostaining for Ki-67 is shorter than for a patient with negative immunostaining, (log-rank test, p = 0.00882). Patients with tumor size T3 and T4 showed a statistically significant relationship with Ki-67 immunoexpression (log-rank test, p = 0.0174). The relationship between Ki-67 expression and the relation between age, gender, smoking, tumor site, lymph node metastasis and disease stage was not significant. The examiners agreement degree by Kappa presented p value < 0.05. There was not a significant correlation when we evaluated MCM3 expression regarding clinical characteristics and survival rate. From these results, the present study suggests that positive Ki-67 expression found in OSCC patients may contribute to predict the survival in OSCC samples, as well as the relation between the protein and the tumor size.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title brazilian oral research
Publication Year Start




PMID- 28832714
OWN - NLM
STAT- MEDLINE
DA  - 20170823
DCOM- 20170912
LR  - 20170912
IS  - 1807-3107 (Electronic)
IS  - 1806-8324 (Linking)
VI  - 31
DP  - 2017 Aug 21
TI  - Ki-67 protein predicts survival in oral squamous carcinoma cells: an
      immunohistochemical study.
PG  - e66
LID - S1806-83242017000100256 [pii]
LID - 10.1590/1807-3107BOR-2017.vol31.0066 [doi]
AB  - The aim of this study was to identify the expression of Ki-67 and MCM3 in oral
      squamous cell carcinoma (OSCC) as well as to address the correlation with patient
      survival and clinical features. Samples were collected from 51 patients with OSCC
      who presented for follow-up. Immunohistochemical expression of Ki-67 and MCM3 in 
      all groups was performed. The scoring system was previous published by Tsurutani 
      in 2005. We used Kappa index to evaluate observers agreement degree. The
      associations between protein expression and clinical variables were examined for 
      statistical significance using the chi-squared test. The overall survival rates
      were estimated by the Kaplan-Meier method and the relationship between protein
      expression and survival was compared using the log-rank test (p &lt; 0.05). The
      overall survival time for a patient with positive immunostaining for Ki-67 is
      shorter than for a patient with negative immunostaining, (log-rank test, p =
      0.00882). Patients with tumor size T3 and T4 showed a statistically significant
      relationship with Ki-67 immunoexpression (log-rank test, p = 0.0174). The
      relationship between Ki-67 expression and the relation between age, gender,
      smoking, tumor site, lymph node metastasis and disease stage was not significant.
      The examiners agreement degree by Kappa presented p value &lt; 0.05. There was not a
      significant correlation when we evaluated MCM3 expression regarding clinical
      characteristics and survival rate. From these results, the present study suggests
      that positive Ki-67 expression found in OSCC patients may contribute to predict
      the survival in OSCC samples, as well as the relation between the protein and the
      tumor size.
FAU - Lopes, Verena Karla Monteiro
AU  - Lopes VKM
AD  - Universidade Federal do Para - UFPA, Joao de Barros Barreto University Hospital, 
      PA, Brazil.
FAU - Jesus, Adriana Souza de
AU  - Jesus AS
AD  - Universidade Federal do Para - UFPA, Joao de Barros Barreto University Hospital, 
      PA, Brazil.
FAU - Souza, Lucas Lacerda de
AU  - Souza LL
AD  - Universidade Federal do Para - UFPA, Joao de Barros Barreto University Hospital, 
      PA, Brazil.
FAU - Miyahara, Ligia Akiko Ninokata
AU  - Miyahara LAN
AD  - Universidade Federal do Para - UFPA, Joao de Barros Barreto University Hospital, 
      PA, Brazil.
FAU - Guimaraes, Douglas Magno
AU  - Guimaraes DM
AD  - Universidade Federal do Para - UFPA, Joao de Barros Barreto University Hospital, 
      PA, Brazil.
FAU - Pontes, Helder Antonio Rebelo
AU  - Pontes HAR
AD  - Universidade Federal do Para - UFPA, Joao de Barros Barreto University Hospital, 
      PA, Brazil.
FAU - Pontes, Flavia Sirotheau Correa
AU  - Pontes FSC
AD  - Universidade Federal do Para - UFPA, Joao de Barros Barreto University Hospital, 
      PA, Brazil.
FAU - Carvalho, Pedro Luiz de
AU  - Carvalho PL
AD  - Universidade Federal do Para - UFPA, Belem, PA, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170821
PL  - Brazil
TA  - Braz Oral Res
JT  - Brazilian oral research
JID - 101307187
RN  - 0 (Ki-67 Antigen)
RN  - 0 (MCM3 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - EC 3.6.4.12 (Minichromosome Maintenance Complex Component 3)
SB  - D
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/*metabolism/*mortality/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Ki-67 Antigen/analysis/*metabolism
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Minichromosome Maintenance Complex Component 3/*metabolism
MH  - Mouth Neoplasms/*metabolism/*mortality/pathology
MH  - Neoplasm Proteins/metabolism
MH  - Neoplasm Staging
MH  - Paraffin Embedding
MH  - Reference Values
MH  - Sex Factors
MH  - Time Factors
MH  - Tumor Burden
EDAT- 2017/08/24 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/08/24 06:00
PHST- 2017/02/15 [received]
PHST- 2017/06/02 [accepted]
AID - S1806-83242017000100256 [pii]
AID - 10.1590/1807-3107BOR-2017.vol31.0066 [doi]
PST - epublish
SO  - Braz Oral Res. 2017 Aug 21;31:e66. doi: 10.1590/1807-3107BOR-2017.vol31.0066.