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Cushing's syndrome secondary to typical pulmonary carcinoid with mutation in BCOR gene: A case report.

Abstract Typical pulmonary carcinoid is a kind of low-grade malignancy neuroendocrine tumor. Cushing's syndrome is a very rare clinical feature of typical pulmonary carcinoid caused by hypercorticism. Complete tumor resection is the standard curative treatment for primary typical pulmonary carcinoid. However, our knowledge on the gene level of typical pulmonary carcinoid is limited.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28834902
OWN - NLM
STAT- MEDLINE
DA  - 20170823
DCOM- 20170912
LR  - 20170912
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 34
DP  - 2017 Aug
TI  - Cushing's syndrome secondary to typical pulmonary carcinoid with mutation in BCOR
      gene: A case report.
PG  - e7870
LID - 10.1097/MD.0000000000007870 [doi]
AB  - RATIONALE: Typical pulmonary carcinoid is a kind of low-grade malignancy
      neuroendocrine tumor. Cushing's syndrome is a very rare clinical feature of
      typical pulmonary carcinoid caused by hypercorticism. Complete tumor resection is
      the standard curative treatment for primary typical pulmonary carcinoid. However,
      our knowledge on the gene level of typical pulmonary carcinoid is limited.
      PATIENT CONCERNS: A 42-year-old man was admitted to our hospital for progressive 
      weight gain within one year. No other obvious symptoms were obsessed in this
      patient. He was clinical diagnosed with ectopic adrenocorticotropic hormone
      syndrome through hormonal tests and imaging exams. Positron emission
      tomography-computed tomography detected a pulmonary nodule localized in the
      middle lobe of the lung and it is thought to be the ectopic source. INTERVENTION:
      This patient received a pulmonary wedge resection. After the surgery, a genetic
      sequencing was performed and it reported a mutation (S1240Cfs*21) in the BCOR
      gene. DIAGNOSIS: Postoperative pathology confirmed the diagnosis of
      ACTH-producing typical pulmonary carcinoid. OUTCOMES: The patient had a smooth
      postoperative course and no recurrence of the tumor was found for 3 years.
      LESSONS: Mutation in BCOR gene is quite common in pulmonary neuroendocrine tumor 
      and it has been proven to play a role in the development of some tumor. We herein
      first report BCOR gene mutation in Cushing's syndrome secondary to TPC and it may
      become a promising therapeutic target in the future.
FAU - Wu, Yimin
AU  - Wu Y
AD  - aDepartment of Thoracic Surgery, the Second Affiliated Hospital, College of
      Medicine, Zhejiang University, Hangzhou b3D Medicines Corporation, Shanghai,
      China.
FAU - Yue, Lan
AU  - Yue L
FAU - Li, Jinfan
AU  - Li J
FAU - Yuan, Mingjing
AU  - Yuan M
FAU - Chai, Ying
AU  - Chai Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (BCOR protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Repressor Proteins)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Carcinoid Tumor/*complications/surgery
MH  - Cushing Syndrome/*etiology/*genetics
MH  - Humans
MH  - Lung Neoplasms/*complications/surgery
MH  - Male
MH  - Mutation
MH  - Proto-Oncogene Proteins/*genetics
MH  - Repressor Proteins/*genetics
PMC - PMC5572024
EDAT- 2017/08/24 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/08/24 06:00
AID - 10.1097/MD.0000000000007870 [doi]
AID - 00005792-201708250-00039 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Aug;96(34):e7870. doi: 10.1097/MD.0000000000007870.