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Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis.

Abstract Ki67 is a good marker of cell proliferation in a variety of tumors. High ki67 levels are usually associated with poor prognosis. However, the relationship between Ki67 expression and the risk of malignancy of gastrointestinal stromal tumors (GISTs) is still poorly defined. The current meta-analysis was initiated to address this issue.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28834915
OWN - NLM
STAT- In-Process
DA  - 20170823
LR  - 20170907
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 34
DP  - 2017 Aug
TI  - Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors:
      A systematic review and meta-analysis.
PG  - e7911
LID - 10.1097/MD.0000000000007911 [doi]
AB  - BACKGROUND: Ki67 is a good marker of cell proliferation in a variety of tumors.
      High ki67 levels are usually associated with poor prognosis. However, the
      relationship between Ki67 expression and the risk of malignancy of
      gastrointestinal stromal tumors (GISTs) is still poorly defined. The current
      meta-analysis was initiated to address this issue. METHODS: Studies reporting
      Ki67 expression and the risk of malignancy in GIST were found by searching
      Cochrane Library, PubMed, Medline, and Embase until October 31, 2016. A total of 
      9 studies involving 982 patients were included. Pooled odds ratio (OR) estimates 
      and 95% confidence intervals (CIs) were calculated using a fixed-effect model.
      RESULTS: Meta-analysis showed no significant difference in the incidence of Ki67 
      overexpression between the very low NIH group and the low NIH group (OR: 0.66,
      95% CI: 0.25-1.76; P = .41, Pheterogeneity = .25). However, the incidence of Ki67
      overexpression gradually increased from the low NIH group to the high NIH group
      (OR: 0.46, 95% CI: 0.27-0.80; P = .005, Pheterogeneity = .13) and (OR: 0.22, 95% 
      CI: 0.15-0.34; P < .00001, Pheterogeneity = .33). CONCLUSIONS: There were more
      GIST patients with Ki67 overexpression in the intermediate and high NIH groups
      than in the low NIH group. Ki67 overexpression may be a useful marker of the risk
      of malignant GIST transformation.
FAU - Zhou, Yu
AU  - Zhou Y
AD  - aDepartment of General Surgery, Suzhou Municipal Hospital (North Campus), Suzhou,
      Jiangsu Province, China bDepartment of Gastrointestinal Surgery, Clinical Medical
      College of Yangzhou University (the Northern Jiangsu People's Hospital),
      Yangzhou, Jiangsu Province, China cDepartment of Surgery, Heji Hospital
      Affiliated to Changzhi Medical College, Changzhi, China dDivision for Health
      Service Promotion, University of Tokyo, Tokyo, Japan eDepartment of
      Gastrointestinal Surgery, Graduate School of Medicine, University of Tokyo,
      Tokyo, Japan.
FAU - Hu, Wenqing
AU  - Hu W
FAU - Chen, Ping
AU  - Chen P
FAU - Abe, Masanobu
AU  - Abe M
FAU - Shi, Lei
AU  - Shi L
FAU - Tan, Si-Yuan
AU  - Tan SY
FAU - Li, Yong
AU  - Li Y
FAU - Zong, Liang
AU  - Zong L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
PMC - PMC5572037
EDAT- 2017/08/24 06:00
MHDA- 2017/08/24 06:00
CRDT- 2017/08/24 06:00
AID - 10.1097/MD.0000000000007911 [doi]
AID - 00005792-201708250-00052 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Aug;96(34):e7911. doi: 10.1097/MD.0000000000007911.