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Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats.

Abstract Euphorbia hirta linn., is a species of Euphorbiaceae family. They are known as asthma plant, barokhervi. The plant E. hirta is famous for its medicinal importance among the tribal population. It is a common practice to use the whole to heal wounds. Several pharmacological properties including antiseptic, anti-inflammatory, antidibetic, antispasmodic, antibacterial, antiviral, antifungal, anticonvulsant, nootropic, antifertility and aphrodisiac properties have already been reported for this plant. The aim of present work was to evaluate the wound healing property in diabetic animals by oral and topical administration of ethanolic extract of E. hirta whole plant.
PMID
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Authors

Mayor MeshTerms
Keywords

Alloxan

Euphorbia hirta

Malondialdehyde

Nitric oxide

Wound healing

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28836990
OWN - NLM
STAT- In-Process
DA  - 20170824
LR  - 20170831
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Aug 24
TI  - Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced 
      diabetic rats.
PG  - 423
LID - 10.1186/s12906-017-1930-x [doi]
AB  - BACKGROUND: Euphorbia hirta linn., is a species of Euphorbiaceae family. They are
      known as asthma plant, barokhervi. The plant E. hirta is famous for its medicinal
      importance among the tribal population. It is a common practice to use the whole 
      to heal wounds. Several pharmacological properties including antiseptic,
      anti-inflammatory, antidibetic, antispasmodic, antibacterial, antiviral,
      antifungal, anticonvulsant, nootropic, antifertility and aphrodisiac properties
      have already been reported for this plant. The aim of present work was to
      evaluate the wound healing property in diabetic animals by oral and topical
      administration of ethanolic extract of E. hirta whole plant. METHODS: The
      ethanolic extract of E. hirta was subjected to determine the total phenolic
      content and total flavonoid content using galic acid and quercetin, respectively 
      as standard. A single injection of alloxan monohydrate (120 mg/kg, i.p.) prepared
      in normal saline was administered to produce diabetes in rats, after overnight
      fasting. For analyzing the rate of contraction of wound, excision wounds sized
      4.90cm2 and of 2 mm depth were used. Oral (100, 200 and 400 mg/kg/day; p.o.) and 
      topical treatment with the extract (5% and 10% ointment 50 mg/kg/day) and
      standard (5% povidone iodine ointment 50 mg/kg/day) was started on the day of
      induction of wound and continued up to 16 days. The means of wound area
      measurement between groups at different time intervals were compared using ANOVA 
      and Dunnet's test. The diabetic wound healing mechanism was studied by measuring 
      the plasma level of glucose, malondialdehyde (MDA) and nitric oxide (NO) in both 
      control and treated groups. For the confirmation of activity, histopathology of
      the wounds tissues from excision wound model was performed. RESULTS:
      Phytochemical investigations showed the presence of various phytoconstituents
      (carbohydrates, saponins, alkaloids, glycosides, steroids, flavonoids, tannins). 
      In the ethanolic extract of E. hirta the total phenol content was 285 +/- 3.22
      mg/g whereas the total flavonoid content was 118.46 +/- 1.85 mg/g. In the present
      study, E. hirta caused significant wound closer both orally (35.92%, 44.69% and
      61.42% at the doses of 100, 200 and 400, respectively) and topically (32.86% and 
      36.32% at the doses of 5% and 10%) treated groups as compared to diabetic
      control. However, the orally treated groups showed more significant effect than
      the topically treated groups. Moreover, oral administration of E. hirta ethanolic
      extract significantly reduced the blood glucose levels in diabetic wound rats (p 
      < 0.01) on day 8 and day 16 as compared to the diabetic wound control (p < 0.01).
      On the other hand, topical application of E. hirta did not influence the blood
      glucose levels in diabetic rats (p > 0.05). It also demonstrated a significant
      decrease in the plasma levels of lipid malondialdehyde and nitric oxide. The
      results of biochemical parameters were further supported by the histopathological
      changes of different organs (liver, pancrease, kidney, heart and skin from wound 
      area) which were evidenced through a decrease in inflammatory cell infiltration. 
      CONCLUSION: The present study demonstrates that E. hirta whole plant extract
      promotes healing of wounds more significantly as compared to diabetic control
      rats, where healing is otherwise delayed.
FAU - Tuhin, Riazul Haque
AU  - Tuhin RH
AD  - Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
FAU - Begum, Marium
AU  - Begum M
AD  - Department of Pharmacy, East West University, Aftabnagar, Dhaka, 1212,
      Bangladesh.
FAU - Rahman, Sohanur
AU  - Rahman S
AD  - Graduate School of Innovative life Science, University of Toyama, 3190 Gofuku,
      Toyama, 930-8555, Japan.
FAU - Karim, Rubaba
AU  - Karim R
AD  - Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
FAU - Begum, Taslima
AU  - Begum T
AD  - Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
FAU - Ahmed, Siraj Uddin
AU  - Ahmed SU
AD  - Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
FAU - Mostofa, Ronia
AU  - Mostofa R
AD  - Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
FAU - Hossain, Amir
AU  - Hossain A
AD  - Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
FAU - Abdel-Daim, Mohamed
AU  - Abdel-Daim M
AD  - Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University,
      Ismailia, 41522, Egypt.
FAU - Begum, Rayhana
AU  - Begum R
AD  - Department of Pharmacy, Primeasia University, Dhaka, 1213, Bangladesh.
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170824
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
PMC - PMC5571567
OTO - NOTNLM
OT  - Alloxan
OT  - Euphorbia hirta
OT  - Malondialdehyde
OT  - Nitric oxide
OT  - Wound healing
EDAT- 2017/08/25 06:00
MHDA- 2017/08/25 06:00
CRDT- 2017/08/25 06:00
PHST- 2017/01/17 [received]
PHST- 2017/08/16 [accepted]
AID - 10.1186/s12906-017-1930-x [doi]
AID - 10.1186/s12906-017-1930-x [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Aug 24;17(1):423. doi: 10.1186/s12906-017-1930-x.