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Orientation of the Temporal Nerve Fiber Raphe in Healthy and in Glaucomatous Eyes.

Abstract To determine the normal variation in orientation of the temporal nerve fiber raphe, and the accuracy with which it may be predicted or approximated in lieu of direct measurement.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28837723
OWN - NLM
STAT- MEDLINE
DA  - 20170824
DCOM- 20170904
LR  - 20170904
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Orientation of the Temporal Nerve Fiber Raphe in Healthy and in Glaucomatous
      Eyes.
PG  - 4211-4217
LID - 10.1167/iovs.17-21995 [doi]
AB  - Purpose: To determine the normal variation in orientation of the temporal nerve
      fiber raphe, and the accuracy with which it may be predicted or approximated in
      lieu of direct measurement. Methods: We previously described an algorithm for
      automatic measurement of raphe orientation from optical coherence tomography,
      using the intensity of vertically oriented macular cubes. Here this method was
      applied in 49 healthy participants (age 19-81 years) and 51 participants with
      primary open angle glaucoma (age 51-80 years). Results: Mean fovea-disc-raphe
      angle was 173.5 degrees +/- 3.2 degrees (range = 166 degrees -182 degrees ) and
      174.2 degrees +/- 3.4 degrees (range = 166 degrees -184 degrees ) in healthy and 
      glaucoma patients, respectively. Differences between groups were not significant.
      Fovea-disc-raphe angle was not correlated with age or axial length (P > 0.4),
      showed some symmetry between eyes in glaucoma (R2 = 0.31, P < 0.001), and little 
      symmetry in the healthy group (P = 0.06). Fovea-disc angle was correlated with
      fovea-raphe angle (R2 = 0.27, P = 0.0001), but was not a good predictor for raphe
      orientation (average error = 6.8 degrees ). The horizontal axis was a better
      predictor (average error = 3.2 degrees ; maximum error = 9.6 degrees ), but still
      gave approximately twice the error previously reported for direct measurement
      from macular cubes. Conclusions: There is substantial natural variation in
      temporal nerve fiber raphe orientation, which cannot be predicted from age, axial
      length, relative geometry of the disc and fovea, or the contralateral eye. For
      applications to which the orientation of the raphe is considered important, it
      should be measured directly.
FAU - Bedggood, Phillip
AU  - Bedggood P
AD  - Department of Optometry & Vision Sciences, The University of Melbourne,
      Australia.
FAU - Nguyen, Bao
AU  - Nguyen B
AD  - Department of Optometry & Vision Sciences, The University of Melbourne,
      Australia.
FAU - Lakkis, Graham
AU  - Lakkis G
AD  - Department of Optometry & Vision Sciences, The University of Melbourne,
      Australia.
FAU - Turpin, Andrew
AU  - Turpin A
AD  - Department of Computing and Information Systems, The University of Melbourne,
      Australia.
FAU - McKendrick, Allison M
AU  - McKendrick AM
AD  - Department of Optometry & Vision Sciences, The University of Melbourne,
      Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - Glaucoma, Primary Open Angle
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma, Open-Angle/*pathology
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Fields
MH  - Young Adult
EDAT- 2017/08/25 06:00
MHDA- 2017/09/05 06:00
CRDT- 2017/08/25 06:00
AID - 2652492 [pii]
AID - 10.1167/iovs.17-21995 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4211-4217. doi:
      10.1167/iovs.17-21995.