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Quantitative Characterization of Autoimmune Uveoretinitis in an Experimental Mouse Model.

Abstract To accurately evaluate the autoimmune inflammation, we aim to develop three quantitative measurements to monitor the inflammatory changes in the retina: retinal-choroidal thickness, major retinal vessel diameter, and electroretinography amplitudes.
PMID
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Authors

Mayor MeshTerms

Disease Models, Animal

Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28837731
OWN - NLM
STAT- MEDLINE
DA  - 20170824
DCOM- 20170904
LR  - 20170904
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Quantitative Characterization of Autoimmune Uveoretinitis in an Experimental
      Mouse Model.
PG  - 4193-4200
LID - 10.1167/iovs.17-22436 [doi]
AB  - Purpose: To accurately evaluate the autoimmune inflammation, we aim to develop
      three quantitative measurements to monitor the inflammatory changes in the
      retina: retinal-choroidal thickness, major retinal vessel diameter, and
      electroretinography amplitudes. Methods: During a 21-day experimental period,
      eyes were examined by confocal scanning laser ophthalmoscopy, optical coherence
      tomography, fundus fluorescein angiography, and electroretinography in living
      mice, which were then subsequently killed for histologic assessments. Results: On
      day 21 postimmunization, inflammation was observed both in vivo and in vitro.
      Fold change of retinal-choroidal thickness and major retinal vessel diameter in
      experimental autoimmune uveoretinitis mice were significantly greater than
      controls (P < 0.001). Both scotopic and photopic electroretinography amplitudes
      were significantly attenuated when compared with control mice (P < 0.01). Our
      results showed that these three quantifiable indicators provided an objective and
      accurate evaluation of autoimmune inflammation, which are in good correlations
      with the reported clinical and histopathologic scoring systems (P < 0.05).
      Conclusions: These three indicators will be useful to detect the small but
      significant differences in the severity of experimental autoimmune uveoretinitis 
      for future longitudinally therapeutic studies.
FAU - Li, Jian
AU  - Li J
AD  - Department of Ophthalmology & Visual Sciences, The Chinese University of Hong
      Kong, Hong Kong, People's Republic of China.
FAU - Ren, Jialin
AU  - Ren J
AD  - School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong,
      People's Republic of China.
FAU - Yip, Yolanda Wong Ying
AU  - Yip YWY
AD  - Department of Ophthalmology & Visual Sciences, The Chinese University of Hong
      Kong, Hong Kong, People's Republic of China.
FAU - Zhang, Xiaoyu
AU  - Zhang X
AD  - Department of Ophthalmology & Visual Sciences, The Chinese University of Hong
      Kong, Hong Kong, People's Republic of China.
FAU - Chu, Kai On
AU  - Chu KO
AD  - Department of Ophthalmology & Visual Sciences, The Chinese University of Hong
      Kong, Hong Kong, People's Republic of China.
FAU - Ng, Tsz Kin
AU  - Ng TK
AD  - Department of Ophthalmology & Visual Sciences, The Chinese University of Hong
      Kong, Hong Kong, People's Republic of China.
FAU - Chan, Sun On
AU  - Chan SO
AD  - School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong,
      People's Republic of China.
FAU - Pang, Chi Pui
AU  - Pang CP
AD  - Department of Ophthalmology & Visual Sciences, The Chinese University of Hong
      Kong, Hong Kong, People's Republic of China.
FAU - Chu, Wai Kit
AU  - Chu WK
AD  - Department of Ophthalmology & Visual Sciences, The Chinese University of Hong
      Kong, Hong Kong, People's Republic of China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Autoantigens)
RN  - 0 (Eye Proteins)
RN  - 0 (Oligopeptides)
RN  - 0 (Retinol-Binding Proteins)
RN  - 0 (interstitial retinol-binding protein)
SB  - IM
MH  - Animals
MH  - Autoantigens
MH  - Autoimmune Diseases/*diagnosis/immunology/physiopathology
MH  - Capillary Permeability
MH  - Dilatation, Pathologic
MH  - *Disease Models, Animal
MH  - Electroretinography
MH  - Eye Proteins
MH  - Female
MH  - Fluorescein Angiography
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Oligopeptides
MH  - Ophthalmoscopy
MH  - Retina/*physiopathology
MH  - Retinal Vessels/*pathology
MH  - Retinitis/*diagnosis/immunology/physiopathology
MH  - Retinol-Binding Proteins
MH  - Uveitis/*diagnosis/immunology/physiopathology
EDAT- 2017/08/25 06:00
MHDA- 2017/09/05 06:00
CRDT- 2017/08/25 06:00
AID - 2652420 [pii]
AID - 10.1167/iovs.17-22436 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4193-4200. doi:
      10.1167/iovs.17-22436.