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L-/M-cone opponency in visual evoked potentials of human cortex.

Abstract L and M cones send their signals to the cortex using two chromatic (parvocellular and blue-yellow koniocellular) and one luminance (magnocellular) pathways. These pathways contain ON and OFF subpathways that respond to excitation increments and decrements respectively. Here, we report on visually evoked potentials (VEP) recordings that reflect L- and M-cone driven increment (LI and MI) and decrement (LD and MD) activity. VEP recordings were performed on 12 trichromats and four dichromats (two protanopes and two deuteranopes). We found that the responses to LI strongly resembled those to MD, and that LD and MI responses were very similar. Moreover, the lack of a photoreceptor type (L or M) in the dichromats led to a dominance of the ON pathway of the remaining photoreceptor type. These results provide electrophysiological evidence that antagonistic L/M signal processing, already present in the retina and the lateral geniculate nucleus (LGN), is also observed at the visual cortex. These data are in agreement with results from human psychophysics where MI stimuli lead to a perceived brightness decrease whereas LI stimuli resulted in perceived brightness increases. VEP recording is a noninvasive tool that can be easily and painlessly applied. We propose that the technique may provide information in the diagnosis of color vision deficiencies.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title journal of vision
Publication Year Start




PMID- 28837966
OWN - NLM
STAT- MEDLINE
DA  - 20170824
DCOM- 20170913
LR  - 20170913
IS  - 1534-7362 (Electronic)
IS  - 1534-7362 (Linking)
VI  - 17
IP  - 9
DP  - 2017 Aug 01
TI  - L-/M-cone opponency in visual evoked potentials of human cortex.
PG  - 20
LID - 10.1167/17.9.20 [doi]
AB  - L and M cones send their signals to the cortex using two chromatic (parvocellular
      and blue-yellow koniocellular) and one luminance (magnocellular) pathways. These 
      pathways contain ON and OFF subpathways that respond to excitation increments and
      decrements respectively. Here, we report on visually evoked potentials (VEP)
      recordings that reflect L- and M-cone driven increment (LI and MI) and decrement 
      (LD and MD) activity. VEP recordings were performed on 12 trichromats and four
      dichromats (two protanopes and two deuteranopes). We found that the responses to 
      LI strongly resembled those to MD, and that LD and MI responses were very
      similar. Moreover, the lack of a photoreceptor type (L or M) in the dichromats
      led to a dominance of the ON pathway of the remaining photoreceptor type. These
      results provide electrophysiological evidence that antagonistic L/M signal
      processing, already present in the retina and the lateral geniculate nucleus
      (LGN), is also observed at the visual cortex. These data are in agreement with
      results from human psychophysics where MI stimuli lead to a perceived brightness 
      decrease whereas LI stimuli resulted in perceived brightness increases. VEP
      recording is a noninvasive tool that can be easily and painlessly applied. We
      propose that the technique may provide information in the diagnosis of color
      vision deficiencies.
FAU - Barboni, Mirella Telles Salgueiro
AU  - Barboni MTS
AD  - Department of Experimental Psychology, University of Sao Paulo, Brazil.
AD  - Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
FAU - Nagy, Balazs Vince
AU  - Nagy BV
AD  - Department of Experimental Psychology, University of Sao Paulo, Brazil.
AD  - Department of Mechatronics, Optics and Engineering Informatics, Budapest
      University of Technology and Economics, Budapest, Hungary.
FAU - Martins, Cristiane Maria Gomes
AU  - Martins CMG
AD  - Department of Experimental Psychology, University of Sao Paulo, Brazil.
FAU - Bonci, Daniela Maria Oliveria
AU  - Bonci DMO
AD  - Department of Experimental Psychology, University of Sao Paulo, Brazil.
AD  - Instituto Israelita de Ensino e Pesquisa Albert Einstein, Sao Paulo, Brazil.
FAU - Hauzman, Einat
AU  - Hauzman E
AD  - Department of Experimental Psychology, University of Sao Paulo, Brazil.
AD  - Instituto Israelita de Ensino e Pesquisa Albert Einstein, Sao Paulo, Brazil.
FAU - Aher, Avinash
AU  - Aher A
AD  - Department of Ophthalmology, University Hospital Erlangen, Germany.
FAU - Tsai, Tina I
AU  - Tsai TI
AD  - Department of Ophthalmology, University Hospital Erlangen, Germany.
FAU - Kremers, Jan
AU  - Kremers J
AD  - Department of Ophthalmology, University Hospital Erlangen, Germany.
FAU - Ventura, Dora Fix
AU  - Ventura DF
AD  - Department of Experimental Psychology, University of Sao Paulo, Brazil.
AD  - Instituto Israelita de Ensino e Pesquisa Albert Einstein, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Vis
JT  - Journal of vision
JID - 101147197
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Color Perception/*physiology
MH  - Color Vision Defects/*physiopathology
MH  - Evoked Potentials, Visual/*physiology
MH  - Geniculate Bodies/*physiology
MH  - Humans
MH  - Photic Stimulation/methods
MH  - Retinal Cone Photoreceptor Cells/*physiology
MH  - Visual Cortex/*physiology
MH  - Visual Pathways/physiology
MH  - Young Adult
EDAT- 2017/08/25 06:00
MHDA- 2017/09/14 06:00
CRDT- 2017/08/25 06:00
AID - 2650867 [pii]
AID - 10.1167/17.9.20 [doi]
PST - ppublish
SO  - J Vis. 2017 Aug 1;17(9):20. doi: 10.1167/17.9.20.