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The Unique Microbiology and Molecular Pathogenesis of Mycoplasma genitalium.

Abstract Mycoplasma genitalium is increasingly appreciated as a common cause of sexually transmitted disease syndromes, including urethritis in men and cervicitis, endometritis, pelvic inflammatory disease, and possibly preterm birth, tubal factor infertility, and ectopic pregnancy in women. Despite these disease associations, which parallel those of Chlamydia trachomatis and Neisseria gonorrhoeae, the mechanisms by which this pathogen elicits inflammation, causes cellular damage, and persists in its only natural host (humans) are unique and are not fully understood. The purpose of this review is to briefly provide a historical background on the discovery, microbiology, and recognition of M. genitalium as a pathogen, and then summarize the recent advances in our understanding of the molecular biology and pathogenesis of this unique urogenital organism. Collectively, the basic scientific discussions herein should provide a framework for understanding the clinical and epidemiological outcomes described in the accompanying articles in this supplemental issue.
PMID
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Authors

Mayor MeshTerms

Immune Evasion

Keywords

genitalium

immunity

mycoplasma

recombination

regulation

Journal Title the journal of infectious diseases
Publication Year Start




PMID- 28838077
OWN - NLM
STAT- MEDLINE
DA  - 20170825
DCOM- 20170905
LR  - 20170906
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 216
IP  - suppl_2
DP  - 2017 Jul 15
TI  - The Unique Microbiology and Molecular Pathogenesis of Mycoplasma genitalium.
PG  - S382-S388
LID - 10.1093/infdis/jix172 [doi]
AB  - Mycoplasma genitalium is increasingly appreciated as a common cause of sexually
      transmitted disease syndromes, including urethritis in men and cervicitis,
      endometritis, pelvic inflammatory disease, and possibly preterm birth, tubal
      factor infertility, and ectopic pregnancy in women. Despite these disease
      associations, which parallel those of Chlamydia trachomatis and Neisseria
      gonorrhoeae, the mechanisms by which this pathogen elicits inflammation, causes
      cellular damage, and persists in its only natural host (humans) are unique and
      are not fully understood. The purpose of this review is to briefly provide a
      historical background on the discovery, microbiology, and recognition of M.
      genitalium as a pathogen, and then summarize the recent advances in our
      understanding of the molecular biology and pathogenesis of this unique urogenital
      organism. Collectively, the basic scientific discussions herein should provide a 
      framework for understanding the clinical and epidemiological outcomes described
      in the accompanying articles in this supplemental issue.
CI  - (c) The Author 2017. Published by Oxford University Press for the Infectious
      Diseases Society of America. All rights reserved. For permissions, e-mail:
      [email protected]
FAU - McGowin, Chris L
AU  - McGowin CL
AD  - Departments of 1 Microbiology, Immunology, and Parasitology.
AD  - Internal Medicine (Section of Infectious Diseases), Louisiana State University
      Health Sciences Center, New Orleans.
FAU - Totten, Patricia A
AU  - Totten PA
AD  - Departments of 3 Medicine (Division of Infectious Diseases).
AD  - Global Health (Pathobiology Interdisciplinary Program), University of Washington,
      Seattle.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - AIM
SB  - IM
MH  - Female
MH  - Genome, Bacterial
MH  - Humans
MH  - *Immune Evasion
MH  - Immunity
MH  - Male
MH  - Mycoplasma Infections/*immunology
MH  - Mycoplasma genitalium/*genetics/immunology/*pathogenicity
MH  - Risk Factors
MH  - Sexually Transmitted Diseases, Bacterial/complications/*immunology
MH  - Urethritis/complications/microbiology
MH  - Uterine Cervicitis/complications/microbiology
OTO - NOTNLM
OT  - genitalium
OT  - immunity
OT  - mycoplasma
OT  - recombination
OT  - regulation
EDAT- 2017/08/26 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/08/26 06:00
AID - 4040971 [pii]
AID - 10.1093/infdis/jix172 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Jul 15;216(suppl_2):S382-S388. doi: 10.1093/infdis/jix172.