PubTransformer

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PMID- 28838147
OWN - NLM
STAT- In-Process
DA  - 20170825
LR  - 20170825
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 216
IP  - 2
DP  - 2017 Jul 15
TI  - Specific Biomarkers Associated With Neurological Complications and Congenital
      Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil.
PG  - 172-181
LID - 10.1093/infdis/jix261 [doi]
AB  - Background: Zika virus (ZIKV) infections have been linked to different levels of 
      clinical outcomes, ranging from mild rash and fever to severe neurological
      complications and congenital malformations. Methods: We investigated the clinical
      and immunological response, focusing on the immune mediators profile in 95 acute 
      ZIKV-infected adult patients from Campinas, Brazil. These patients included 6
      pregnant women who later delivered during the course of this study. Clinical
      observations were recorded during hospitalization. Levels of 45 immune mediators 
      were quantified using multiplex microbead-based immunoassays. Results: Whereas
      11.6% of patients had neurological complications, 88.4% displayed mild disease of
      rash and fever. Several immune mediators were specifically higher in
      ZIKV-infected patients, and levels of interleukin 10, interferon gamma-induced
      protein 10 (IP-10), and hepatocyte growth factor differentiated between patients 
      with or without neurological complications. Interestingly, higher levels of
      interleukin 22, monocyte chemoattractant protein 1, TNF-alpha, and IP-10 were
      observed in ZIKV-infected pregnant women carrying fetuses with fetal
      growth-associated malformations. Notably, infants with congenital central nervous
      system deformities had significantly higher levels of interleukin 18 and IP-10
      but lower levels of hepatocyte growth factor than those without such
      abnormalities born to ZIKV-infected mothers. Conclusions: This study identified
      several key markers for the control of ZIKV pathogenesis. This will allow a
      better understanding of the molecular mechanisms of ZIKV infection in patients.
FAU - Kam, Yiu-Wing
AU  - Kam YW
AD  - Singapore Immunology Network, Agency for Science, Technology and Research
      (A*STAR).
FAU - Leite, Juliana Almeida
AU  - Leite JA
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University
      of Campinas (Unicamp), Sao Paulo.
FAU - Lum, Fok-Moon
AU  - Lum FM
AD  - Singapore Immunology Network, Agency for Science, Technology and Research
      (A*STAR).
FAU - Tan, Jeslin J L
AU  - Tan JJL
AD  - Singapore Immunology Network, Agency for Science, Technology and Research
      (A*STAR).
FAU - Lee, Bernett
AU  - Lee B
AD  - Singapore Immunology Network, Agency for Science, Technology and Research
      (A*STAR).
FAU - Judice, Carla C
AU  - Judice CC
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University
      of Campinas (Unicamp), Sao Paulo.
FAU - Teixeira, Daniel Augusto de Toledo
AU  - Teixeira DAT
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University
      of Campinas (Unicamp), Sao Paulo.
FAU - Andreata-Santos, Robert
AU  - Andreata-Santos R
AD  - Biomedical Science Institute, Department of Microbiology, University of Sao
      Paulo.
FAU - Vinolo, Marco A
AU  - Vinolo MA
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University
      of Campinas (Unicamp), Sao Paulo.
FAU - Angerami, Rodrigo
AU  - Angerami R
AD  - Epidemiological Surveillance Section, Hospital of Clinics.
FAU - Resende, Mariangela Ribeiro
AU  - Resende MR
AD  - Department of Internal Medicine, Faculty of Medical Sciences, Unicamp, Campinas, 
      Sao Paulo.
FAU - Freitas, Andre Ricardo Ribas
AU  - Freitas ARR
AD  - Obstetrics and Gynecology Department, School of Medical Sciences, University of
      Campinas (Unicamp).
FAU - Amaral, Eliana
AU  - Amaral E
AD  - Campinas Department of Public Health Surveillance, Brazil.
FAU - Junior, Renato Passini
AU  - Junior RP
AD  - Campinas Department of Public Health Surveillance, Brazil.
FAU - Costa, Maria Laura
AU  - Costa ML
AD  - Campinas Department of Public Health Surveillance, Brazil.
FAU - Guida, Jose Paulo
AU  - Guida JP
AD  - Campinas Department of Public Health Surveillance, Brazil.
FAU - Arns, Clarice Weis
AU  - Arns CW
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University
      of Campinas (Unicamp), Sao Paulo.
FAU - Ferreira, Luis Carlos S
AU  - Ferreira LCS
AD  - Biomedical Science Institute, Department of Microbiology, University of Sao
      Paulo.
FAU - Renia, Laurent
AU  - Renia L
AD  - Singapore Immunology Network, Agency for Science, Technology and Research
      (A*STAR).
FAU - Proenca-Modena, Jose Luiz
AU  - Proenca-Modena JL
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University
      of Campinas (Unicamp), Sao Paulo.
FAU - Ng, Lisa F P
AU  - Ng LFP
AD  - Singapore Immunology Network, Agency for Science, Technology and Research
      (A*STAR).
AD  - Institute of Infection and Global Health, University of Liverpool, United
      Kingdom.
FAU - Costa, Fabio T M
AU  - Costa FTM
AD  - Department of Genetics, Evolution and Bioagents, Institute of Biology, University
      of Campinas (Unicamp), Sao Paulo.
CN  - Zika-Unicamp Network
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
OTO - NOTNLM
OT  - Zika virus
OT  - congenital CNS deformities
OT  - cytokines and biomarkers
EDAT- 2017/08/26 06:00
MHDA- 2017/08/26 06:00
CRDT- 2017/08/26 06:00
PHST- 2017/04/19 [received]
PHST- 2017/05/26 [accepted]
AID - 3858563 [pii]
AID - 10.1093/infdis/jix261 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Jul 15;216(2):172-181. doi: 10.1093/infdis/jix261.