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Mini-Review on Cachexia-Related miRNA.

Abstract Cachexia, or muscle wasting, is a complex metabolic syndrome associated with an underlying illness and characterized by loss of muscle mass. It is a rather prevalent condition, with impacts on patient survival, response to treatment, and quality of life. Treatment options are sparse because of cachexia's multifactorial pathogenesis. Recently, attention has focused on microRNAs (miRNAs) as potential therapeutic targets of several diseases. miRNAs are small, 18- to 25-base-long constructs that regulate gene expression on a post-transcriptional level, selectively activating or repressing elements of specific signaling pathways. In this review, we investigated whether miRNAs play any role in cachexia's biochemical pathways and if miRNA targeting has any significant impact on preclinical models of cachexia.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title critical reviews in eukaryotic gene expression
Publication Year Start




PMID- 28845764
OWN - NLM
STAT- In-Process
DA  - 20170828
LR  - 20170828
IS  - 1045-4403 (Print)
IS  - 1045-4403 (Linking)
VI  - 27
IP  - 2
DP  - 2017
TI  - Mini-Review on Cachexia-Related miRNA.
PG  - 151-161
LID - 10.1615/CritRevEukaryotGeneExpr.2017019085 [doi]
AB  - Cachexia, or muscle wasting, is a complex metabolic syndrome associated with an
      underlying illness and characterized by loss of muscle mass. It is a rather
      prevalent condition, with impacts on patient survival, response to treatment, and
      quality of life. Treatment options are sparse because of cachexia's
      multifactorial pathogenesis. Recently, attention has focused on microRNAs
      (miRNAs) as potential therapeutic targets of several diseases. miRNAs are small, 
      18- to 25-base-long constructs that regulate gene expression on a
      post-transcriptional level, selectively activating or repressing elements of
      specific signaling pathways. In this review, we investigated whether miRNAs play 
      any role in cachexia's biochemical pathways and if miRNA targeting has any
      significant impact on preclinical models of cachexia.
FAU - Sousa Nunes, Fabio
AU  - Sousa Nunes F
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, Porto, 
      Portugal.
FAU - Moreira-Goncalves, Daniel
AU  - Moreira-Goncalves D
AD  - Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, Porto, 
      Portugal.
FAU - Henriques-Coelho, Tiago
AU  - Henriques-Coelho T
AD  - Department of Pediatrics, Faculty of Medicine, Porto, Portugal.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Rev Eukaryot Gene Expr
JT  - Critical reviews in eukaryotic gene expression
JID - 9007261
EDAT- 2017/08/29 06:00
MHDA- 2017/08/29 06:00
CRDT- 2017/08/29 06:00
AID - 74110c836b292a7b,4741ebe0202b3a1a [pii]
AID - 10.1615/CritRevEukaryotGeneExpr.2017019085 [doi]
PST - ppublish
SO  - Crit Rev Eukaryot Gene Expr. 2017;27(2):151-161. doi:
      10.1615/CritRevEukaryotGeneExpr.2017019085.