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ABCB1 Polymorphisms and Childhood Acute Lymphoblastic Leukemia Risk: A Meta-Analysis.

Abstract The association between ATP-binding cassette subfamily B member 1 (ABCB1) C3435T and C1236T polymorphisms and the risk for childhood acute lymphoblastic leukemia (ALL) is inconclusive. We conducted a meta-analysis of all published studies to determine the association of ABCB1 C3435T and C1236T polymorphisms and pediatric ALL risk. A systematic retrieval of relevant publications from the PubMed and Web of Science databases was performed. Data were calculated and statistical analysis was performed using STATA version 12.0 software. Metaanalysis results showed no significant association between C3435T polymorphism and pediatric ALL risk (TT vs. CC: odds ratio [OR] = 1.20, 95% confidence interval [CI] = 0.95-1.52; CT vs. CC: OR = 1.00, 95% CI = 0.82-1.23; the dominant model: OR = 1.07, 95% CI = 0.89-1.29; the recessive model: OR = 1.17, 95% CI = 0.84-1.62). Similarly, there was no association found for the C1236T polymorphism (TT vs. CC: OR = 1.18, 95% CI= 0.82-1.70; CT vs. CC: OR = 1.08, 95% CI = 0.80-1.45; the dominant model: OR = 1.10, 95% CI= 0.83-1.46; the recessive model: OR = 0.98, 95% CI = 0.61-1.58). Similar results were observed in the subgroup analyses on ethnicity and Hardy-Weinberg equilibrium. The present meta-analysis found no evidence for ABCB1 C3435T and C1236T polymorphisms as risk factors for pediatric ALL.
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Mayor MeshTerms
Keywords
Journal Title critical reviews in eukaryotic gene expression
Publication Year Start




PMID- 28845766
OWN - NLM
STAT- In-Process
DA  - 20170828
LR  - 20170828
IS  - 1045-4403 (Print)
IS  - 1045-4403 (Linking)
VI  - 27
IP  - 2
DP  - 2017
TI  - ABCB1 Polymorphisms and Childhood Acute Lymphoblastic Leukemia Risk: A
      Meta-Analysis.
PG  - 173-181
LID - 10.1615/CritRevEukaryotGeneExpr.2017019077 [doi]
AB  - The association between ATP-binding cassette subfamily B member 1 (ABCB1) C3435T 
      and C1236T polymorphisms and the risk for childhood acute lymphoblastic leukemia 
      (ALL) is inconclusive. We conducted a meta-analysis of all published studies to
      determine the association of ABCB1 C3435T and C1236T polymorphisms and pediatric 
      ALL risk. A systematic retrieval of relevant publications from the PubMed and Web
      of Science databases was performed. Data were calculated and statistical analysis
      was performed using STATA version 12.0 software. Metaanalysis results showed no
      significant association between C3435T polymorphism and pediatric ALL risk (TT
      vs. CC: odds ratio [OR] = 1.20, 95% confidence interval [CI] = 0.95-1.52; CT vs. 
      CC: OR = 1.00, 95% CI = 0.82-1.23; the dominant model: OR = 1.07, 95% CI =
      0.89-1.29; the recessive model: OR = 1.17, 95% CI = 0.84-1.62). Similarly, there 
      was no association found for the C1236T polymorphism (TT vs. CC: OR = 1.18, 95%
      CI= 0.82-1.70; CT vs. CC: OR = 1.08, 95% CI = 0.80-1.45; the dominant model: OR =
      1.10, 95% CI= 0.83-1.46; the recessive model: OR = 0.98, 95% CI = 0.61-1.58).
      Similar results were observed in the subgroup analyses on ethnicity and
      Hardy-Weinberg equilibrium. The present meta-analysis found no evidence for ABCB1
      C3435T and C1236T polymorphisms as risk factors for pediatric ALL.
FAU - Zhan, Lu
AU  - Zhan L
AD  - Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310002,
      China.
FAU - Lian, Junlan
AU  - Lian J
AD  - Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310002,
      China.
FAU - Jin, Haili
AU  - Jin H
AD  - Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310002,
      China.
FAU - Wang, Sunyao
AU  - Wang S
AD  - Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310002,
      China.
FAU - Ding, Jiajun
AU  - Ding J
AD  - Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310002,
      China.
FAU - Shao, Zhengyang
AU  - Shao Z
AD  - Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310002,
      China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Rev Eukaryot Gene Expr
JT  - Critical reviews in eukaryotic gene expression
JID - 9007261
EDAT- 2017/08/29 06:00
MHDA- 2017/08/29 06:00
CRDT- 2017/08/29 06:00
AID - 74110c836b292a7b,42bba0955d9266ce [pii]
AID - 10.1615/CritRevEukaryotGeneExpr.2017019077 [doi]
PST - ppublish
SO  - Crit Rev Eukaryot Gene Expr. 2017;27(2):173-181. doi:
      10.1615/CritRevEukaryotGeneExpr.2017019077.