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Role of lncRNAs as Novel Biomarkers and Therapeutic Targets in Ovarian Cancer.

Abstract Ovarian cancer (OC) is the leading cause of death among all gynecological malignancies in the world and its underlying mechanism is still unclear. Compared with research on microRNAs, research on long non-coding RNAs (lncRNAs) is still in its infancy. Studies in recent years have demonstrated that lncRNAs exhibit multiple biological functions in various stages of OC development. In this review, we conclude that lncRNAs are closely involved in the pathogenesis of OC. The expression of lncRNAs indicates the early diagnosis, prognosis, and response to chemotherapy of OC. An attractive approach to treatment of OC is lncRNA small interfering RNA or acting as a plasmid targeting the expression of toxic genes, which is a novel step toward a major breakthrough in the treatment of human OC. E2-regulated lncRNA and its polymorphism, methylation, are also involved in OC. Further research efforts are needed before fully identifying, characterizing, and elucidating the actual functions of lncRNAs in OC at the molecular level and putting them into clinical practice.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title critical reviews in eukaryotic gene expression
Publication Year Start




PMID- 28845767
OWN - NLM
STAT- MEDLINE
DA  - 20170828
DCOM- 20170911
LR  - 20170911
IS  - 1045-4403 (Print)
IS  - 1045-4403 (Linking)
VI  - 27
IP  - 2
DP  - 2017
TI  - Role of lncRNAs as Novel Biomarkers and Therapeutic Targets in Ovarian Cancer.
PG  - 183-195
LID - 10.1615/CritRevEukaryotGeneExpr.2017019244 [doi]
AB  - Ovarian cancer (OC) is the leading cause of death among all gynecological
      malignancies in the world and its underlying mechanism is still unclear. Compared
      with research on microRNAs, research on long non-coding RNAs (lncRNAs) is still
      in its infancy. Studies in recent years have demonstrated that lncRNAs exhibit
      multiple biological functions in various stages of OC development. In this
      review, we conclude that lncRNAs are closely involved in the pathogenesis of OC. 
      The expression of lncRNAs indicates the early diagnosis, prognosis, and response 
      to chemotherapy of OC. An attractive approach to treatment of OC is lncRNA small 
      interfering RNA or acting as a plasmid targeting the expression of toxic genes,
      which is a novel step toward a major breakthrough in the treatment of human OC.
      E2-regulated lncRNA and its polymorphism, methylation, are also involved in OC.
      Further research efforts are needed before fully identifying, characterizing, and
      elucidating the actual functions of lncRNAs in OC at the molecular level and
      putting them into clinical practice.
FAU - Fu, Lu-Lu
AU  - Fu LL
AD  - Department of Obstetrics and Gynecology, the Second Hospital of Jilin University,
      Changchun, China.
FAU - Li, Chun-Jin
AU  - Li CJ
AD  - College of Animal Sciences, Jilin University, Changchun, China.
FAU - Xu, Ying
AU  - Xu Y
AD  - Department of Obstetrics and Gynecology, the Second Hospital of Jilin University,
      Changchun, China.
FAU - Li, Ling-Yun
AU  - Li LY
AD  - Department of Obstetrics and Gynecology, the Second Hospital of Jilin University,
      Changchun, China.
FAU - Zhou, Xu
AU  - Zhou X
AD  - College of Animal Sciences, Jilin University, Changchun, China.
FAU - Li, Dan-Dan
AU  - Li DD
AD  - Department of Obstetrics and Gynecology, the Second Hospital of Jilin University,
      Changchun, China.
FAU - Chen, Shu-Xiong
AU  - Chen SX
AD  - College of Animal Sciences, Jilin University, Changchun, China.
FAU - Wang, Feng-Ge
AU  - Wang FG
AD  - College of Animal Sciences, Jilin University, Changchun, China.
FAU - Zhang, Xue-Ying
AU  - Zhang XY
AD  - Department of Obstetrics and Gynecology, the Second Hospital of Jilin University,
      Changchun, China.
FAU - Zheng, Lian-Wen
AU  - Zheng LW
AD  - Department of Obstetrics and Gynecology, the Second Hospital of Jilin University,
      Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Crit Rev Eukaryot Gene Expr
JT  - Critical reviews in eukaryotic gene expression
JID - 9007261
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Biomarkers, Tumor
MH  - Female
MH  - Humans
MH  - Ovarian Neoplasms/diagnosis/drug therapy/etiology/*metabolism
MH  - Polymorphism, Genetic
MH  - Prognosis
MH  - RNA, Long Noncoding/*drug effects/genetics
EDAT- 2017/08/29 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/08/29 06:00
AID - 74110c836b292a7b,2fcdd0b3517154e8 [pii]
AID - 10.1615/CritRevEukaryotGeneExpr.2017019244 [doi]
PST - ppublish
SO  - Crit Rev Eukaryot Gene Expr. 2017;27(2):183-195. doi:
      10.1615/CritRevEukaryotGeneExpr.2017019244.