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Detection of Early Loss of Color Vision in Age-Related Macular Degeneration - With Emphasis on Drusen and Reticular Pseudodrusen.

Abstract To evaluate chromatic sensitivity in patients with age-related macular degeneration (AMD) characterized by drusen and reticular pseudodrusen. To investigate whether the severity of color vision loss can distinguish between various stages of AMD and hence be used as an index of progression toward advanced AMD.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28846119
OWN - NLM
STAT- MEDLINE
DA  - 20170828
DCOM- 20170904
LR  - 20170904
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 6
DP  - 2017 May 01
TI  - Detection of Early Loss of Color Vision in Age-Related Macular Degeneration -
      With Emphasis on Drusen and Reticular Pseudodrusen.
PG  - BIO247-BIO254
LID - 10.1167/iovs.17-21771 [doi]
AB  - Purpose: To evaluate chromatic sensitivity in patients with age-related macular
      degeneration (AMD) characterized by drusen and reticular pseudodrusen. To
      investigate whether the severity of color vision loss can distinguish between
      various stages of AMD and hence be used as an index of progression toward
      advanced AMD. Methods: Chromatic sensitivity was measured by using the Color
      Assessment and Diagnosis (CAD) test in asymptomatic individuals with early and
      intermediate AMD and compared to normative data. All study participants had
      logMAR visual acuity of 0.3 or better. The CAD thresholds measured in eyes with
      and without reticular pseudodrusen were also compared and related to central
      macular thickness (CMT). Student's t-test P values < 0.05 were considered
      significant. Results: All early- and intermediate-AMD eyes (n = 90) had chromatic
      sensitivity loss in either RG (red/green) or YB (yellow/blue), or both (P <
      0.0001) as compared to age-matched normal subjects. The eyes exhibited a range of
      CAD thresholds affecting both color mechanisms, but YB color thresholds were in
      general higher than RG thresholds (P < 0.001). Intermediate-AMD patients
      exhibited large intersubject variability. In general, eyes with reticular
      pseudodrusen and eyes with CMT < 200 mum had significantly higher CAD thresholds.
      Conclusions: The anatomic integrity of cone photoreceptors remains relatively
      unaffected in early and intermediate stages of AMD. The processing of cone
      signals in the retina can, however, be heavily disrupted with subsequent loss of 
      both YB and RG chromatic sensitivity. The greatest losses were observed in eyes
      with reticular pseudodrusen.
FAU - Vemala, Roopa
AU  - Vemala R
AD  - King's College Hospital, Denmark Hill, London, United Kingdom.
AD  - Applied Vision Research Centre, School of Health Sciences, City, University of
      London, London, United Kingdom.
FAU - Sivaprasad, Sobha
AU  - Sivaprasad S
AD  - King's College Hospital, Denmark Hill, London, United Kingdom.
AD  - NIHR Moorfields Biomedical Research Centre, London, United Kingdom.
FAU - Barbur, John L
AU  - Barbur JL
AD  - Applied Vision Research Centre, School of Health Sciences, City, University of
      London, London, United Kingdom.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Color Perception Tests
MH  - Color Vision Defects/*diagnosis
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Macular Degeneration/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Drusen/*diagnosis
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2017/08/29 06:00
MHDA- 2017/09/05 06:00
CRDT- 2017/08/29 06:00
AID - 2652618 [pii]
AID - 10.1167/iovs.17-21771 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO247-BIO254. doi:
      10.1167/iovs.17-21771.