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Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese.

Abstract Several studies have shown that sympathetic ophthalmia (SO) and Vogt-Koyanagi-Harada (VKH) disease possess many similarities concerning their clinical manifestations. The aim of this study was to investigate whether single nucleotide polymorphisms that have been shown to be associated with VKH disease in earlier studies may also be associated with SO.
PMID
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Authors

Mayor MeshTerms

Polymorphism, Single Nucleotide

Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28846771
OWN - NLM
STAT- MEDLINE
DA  - 20170828
DCOM- 20170904
LR  - 20170904
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Association of a PDCD1 Polymorphism With Sympathetic Ophthalmia in Han Chinese.
PG  - 4218-4222
LID - 10.1167/iovs.17-22195 [doi]
AB  - Purpose: Several studies have shown that sympathetic ophthalmia (SO) and
      Vogt-Koyanagi-Harada (VKH) disease possess many similarities concerning their
      clinical manifestations. The aim of this study was to investigate whether single 
      nucleotide polymorphisms that have been shown to be associated with VKH disease
      in earlier studies may also be associated with SO. Methods: There were 114 SO
      patients and 1230 healthy controls included in a case-control study, whereby 24
      VKH-related single nucleotide polymorphisms (SNPs) were tested. Genotyping was
      performed using the MassARRAY platform and iPLEX Gold Assay. Results: The results
      showed a significantly lower frequency of the PDCD1/rs2227981 GG genotype in SO
      (Pc =7.85 x 10-3, OR = 0.471). However, no apparent increase in the GA and AA
      genotype frequency was detected. Moreover, a significant decrease in the G allele
      frequency of PDCD1/rs2227981 was detected in SO (Pc = 5.08 x 10-3, OR = 0.56).
      Conclusions: This study shows that only PDCD1/rs2227981 contributes to the
      genetic susceptibility of SO, and that the other 23 susceptibility loci of VKH
      disease are probably not involved in the pathogenesis of this disease.
FAU - Deng, Jing
AU  - Deng J
AD  - The First Affiliated Hospital of Chongqing Medical University, Chongqing Key
      Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's
      Republic of China.
FAU - Hu, Jiayue
AU  - Hu J
AD  - The First Affiliated Hospital of Chongqing Medical University, Chongqing Key
      Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's
      Republic of China.
FAU - Tan, Handan
AU  - Tan H
AD  - The First Affiliated Hospital of Chongqing Medical University, Chongqing Key
      Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's
      Republic of China.
FAU - Su, Guannan
AU  - Su G
AD  - The First Affiliated Hospital of Chongqing Medical University, Chongqing Key
      Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's
      Republic of China.
FAU - Cao, Qingfeng
AU  - Cao Q
AD  - The First Affiliated Hospital of Chongqing Medical University, Chongqing Key
      Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's
      Republic of China.
FAU - Huang, Xinyue
AU  - Huang X
AD  - The First Affiliated Hospital of Chongqing Medical University, Chongqing Key
      Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's
      Republic of China.
FAU - Kijlstra, Aize
AU  - Kijlstra A
AD  - University Eye Clinic Maastricht, Maastricht, Limburg, The Netherlands.
FAU - Yang, Peizeng
AU  - Yang P
AD  - The First Affiliated Hospital of Chongqing Medical University, Chongqing Key
      Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's
      Republic of China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian Continental Ancestry Group/*genetics
MH  - Case-Control Studies
MH  - Child
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ophthalmia, Sympathetic/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Programmed Cell Death 1 Receptor/*genetics
MH  - Uveomeningoencephalitic Syndrome/genetics
MH  - Young Adult
EDAT- 2017/08/29 06:00
MHDA- 2017/09/05 06:00
CRDT- 2017/08/29 06:00
AID - 2652620 [pii]
AID - 10.1167/iovs.17-22195 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4218-4222. doi:
      10.1167/iovs.17-22195.