PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28846773
OWN - NLM
STAT- MEDLINE
DA  - 20170828
DCOM- 20170904
LR  - 20170904
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump
      Deformation.
PG  - 4235-4246
LID - 10.1167/iovs.17-22141 [doi]
AB  - Purpose: The purpose of this study was to quantify the biomechanical response of 
      human posterior ocular tissues from donors of various racioethnic groups to
      better understand how differences in these properties may play a role in the
      racioethnic health disparities known to exist in glaucoma. Methods: Sequential
      digital image correlation (S-DIC) was used to measure the pressure-induced
      surface deformations of 23 normal human posterior poles from three racioethnic
      groups: African descent (AD), European descent (ED), and Hispanic ethnicity
      (HIS). Regional in-plane principal strains were compared across three zones: the 
      optic nerve stump (ONS), the peripapillary (PP) sclera, and non-PP sclera.
      Results: The PP scleral tensile strains were found to be lower for ED eyes
      compared with AD and HIS eyes at 15 mm Hg (P = 0.024 and 0.039, respectively).
      The mean compressive strains were significantly higher for AD eyes compared with 
      ED eyes at 15 mm Hg (P = 0.018). We also found that the relationship between
      tensile strain and pressure was significant for those of ED and HIS eyes (P <
      0.001 and P = 0.004, respectively), whereas it was not significant for those of
      AD (P = 0.392). Conclusions: Our results suggest that, assuming glaucomatous
      nerve loss is caused by mechanical strains in the vicinity of the optic nerve
      head, the mechanism of increased glaucoma prevalence may be different in those of
      AD versus HIS. Our ONS strain analysis also suggested that it may be important to
      account for ONS geometry and material properties in future scleral biomechanical 
      analysis.
FAU - Tamimi, Ehab A
AU  - Tamimi EA
AD  - Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania,
      United States.
FAU - Pyne, Jeffrey D
AU  - Pyne JD
AD  - Department of Mechanical Engineering, University of California Berkeley,
      Berkeley, California, United States.
FAU - Muli, Dominic K
AU  - Muli DK
AD  - Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania,
      United States.
FAU - Axman, Katelyn F
AU  - Axman KF
AD  - Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania,
      United States.
FAU - Howerton, Stephen J
AU  - Howerton SJ
AD  - Department of Aerospace and Mechanical Engineering, University of Arizona,
      Tucson, Arizona, United States.
FAU - Davis, Matthew R
AU  - Davis MR
AD  - Department of Aerospace and Mechanical Engineering, University of Arizona,
      Tucson, Arizona, United States.
FAU - Girkin, Christopher A
AU  - Girkin CA
AD  - Department of Ophthalmology, University of Alabama Birmingham, Birmingham,
      Alabama, United States.
FAU - Vande Geest, Jonathan P
AU  - Vande Geest JP
AD  - Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania,
      United States.
AD  - McGowan Institute for Regenerative Medicine, University of Pittsburgh,
      Pittsburgh, Pennsylvania, United States.
AD  - Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, 
      United States.
AD  - Louis J. Fox Center for Vision Restoration, University of Pittsburgh,
      Pennsylvania, United States.
LA  - eng
GR  - R01 EY020890/EY/NEI NIH HHS/United States
GR  - T32 EB003392/EB/NIBIB NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - *African Continental Ancestry Group
MH  - Aged
MH  - Aged, 80 and over
MH  - Axons/*pathology
MH  - *European Continental Ancestry Group
MH  - Female
MH  - Glaucoma/*ethnology/physiopathology
MH  - *Hispanic Americans
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*ethnology/physiopathology
MH  - Sclera
MH  - Tissue Donors
PMC - PMC5574446
EDAT- 2017/08/29 06:00
MHDA- 2017/09/05 06:00
CRDT- 2017/08/29 06:00
AID - 2652622 [pii]
AID - 10.1167/iovs.17-22141 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4235-4246. doi:
      10.1167/iovs.17-22141.