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Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations.

Abstract We hypothesized that the edema/swelling in the retina due to acute nonarteritic anterior ischemic optic neuropathy (NAION) can induce retinal folds (RF). We determined the pattern and frequency of folds in NAION at presentation and in follow-up, and the relationship between folds and a number of functional and structural parameters over time.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28846776
OWN - NLM
STAT- MEDLINE
DA  - 20170828
DCOM- 20170904
LR  - 20170904
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and
      Deformations.
PG  - 4286-4291
LID - 10.1167/iovs.17-22140 [doi]
AB  - Purpose: We hypothesized that the edema/swelling in the retina due to acute
      nonarteritic anterior ischemic optic neuropathy (NAION) can induce retinal folds 
      (RF). We determined the pattern and frequency of folds in NAION at presentation
      and in follow-up, and the relationship between folds and a number of functional
      and structural parameters over time. Methods: We prospectively studied eyes with 
      acute NAION by spectral-domain optic coherence tomography (SD-OCT). We used
      transaxial and en face views to evaluate the presence of peripapillary fluid
      (PPF), peripapillary wrinkles (PPW), RF, choroidal folds (CF), creases, macular
      edema, and vitreous traction on the optic disc. Retinal deformations were
      correlated with the retinal nerve fiber layer (RNFL) thickness, logMAR visual
      acuity (VA) and mean deviation (MD). Results: At presentation, 60 eyes had mean
      RNFL = 224 +/- 75 mum, no vitreous traction, and similar VA and MD regardless of 
      the retinal deformation or macular edema. There was PPF in 73%, PPW in 57%, RF in
      38%, creases in 20%, and macular edema in 18% of eyes, and no CF. Eyes with
      retinal deformations had significantly greater RNFL thickness (P< 0.026). At 1 to
      2 months, 49 eyes had reduction of the RNFL (112 +/- 40 mum, P = 0.001) and
      unchanged VA and MD that did not correlate with fewer eyes having PPF (15%, P =
      0.001), PPW (10%, P = 0.001), RF (10%, P = 0.001), creases (17%), and macular
      edema (0%, P = 0.007). Conclusions: RF in NAION reflect stresses and strains due 
      to extracellular fluid without increased pressure in the retrolaminar tissue and 
      subarachnoid space, seen with papilledema. In NAION, the deformations and their
      resolution do not correlate with vision loss.
FAU - Kupersmith, Mark J
AU  - Kupersmith MJ
AD  - New York Eye and Ear Infirmary and Icahn School of Medicine at Mount Sinai, New
      York, New York, United States.
FAU - Sibony, Patrick A
AU  - Sibony PA
AD  - Department of Ophthalmology, State University of New York at Stony Brook, Stony
      Brook, New York, United States.
FAU - Dave, Sarita
AU  - Dave S
AD  - New York Eye and Ear Infirmary and Icahn School of Medicine at Mount Sinai, New
      York, New York, United States.
LA  - eng
GR  - U10 EY017281/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Acute Disease
MH  - Arteritis/complications
MH  - Choroid Diseases/etiology/physiopathology
MH  - Female
MH  - Humans
MH  - Macular Edema/*etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/pathology
MH  - Optic Neuropathy, Ischemic/*complications/physiopathology
MH  - Prospective Studies
MH  - Retinal Diseases/*etiology/physiopathology
MH  - Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
PMC - PMC5574520
EDAT- 2017/08/29 06:00
MHDA- 2017/09/05 06:00
CRDT- 2017/08/29 06:00
AID - 2652820 [pii]
AID - 10.1167/iovs.17-22140 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4286-4291. doi:
      10.1167/iovs.17-22140.