PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

THE EFFECTS OF Syzygium aromaticum-DERIVED TRITERPENES ON GASTROINTESTINAL GHRELIN EXPRESSION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.

Abstract Diabetic polyphagia has been associated with elevated plasma ghrelin levels in experimental type 1 diabetes. This increase in food consumption contributes to chronic hyperglycaemia in diabetes thus contributing to the development of micro- and macrovascular complications. We have reported that plant-derived oleanolic acid (OA) and maslinic acid (MA) reduce blood glucose levels, in part, through the inhibition of intestinal carbohydrate hydrolyzing enzymes and glucose transporters. However, their effects on food intake and plasma ghrelin concentrations are unclear. Accordingly, we investigated the effects of these triterpenes on food intake and ghrelin expression in streptozotocin-induced diabetic rats.
PMID
Related Publications

The effects of Syzygium aromaticum-derived oleanolic acid on kidney function of male Sprague-Dawley rats and on kidney and liver cell lines.

Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats.

The effects of Syzygium aromaticum-derived oleanolic acid on glycogenic enzymes in streptozotocin-induced diabetic rats.

Renal effects of plant-derived oleanolic acid in streptozotocin-induced diabetic rats.

Effects of Syzygium aromaticum-derived triterpenes on postprandial blood glucose in streptozotocin-induced diabetic rats following carbohydrate challenge.

Authors

Mayor MeshTerms
Keywords

Syzygium aromaticum

diabetes mellitus

ghrelin

maslinic acid

oleanolic acid

triterpenes

Journal Title african journal of traditional, complementary, and alternative medicines : ajtcam
Publication Year Start




PMID- 28852714
OWN - NLM
STAT- MEDLINE
DA  - 20170830
DCOM- 20170908
LR  - 20170908
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 13
IP  - 4
DP  - 2016
TI  - THE EFFECTS OF Syzygium aromaticum-DERIVED TRITERPENES ON GASTROINTESTINAL
      GHRELIN EXPRESSION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.
PG  - 8-14
LID - 10.21010/ajtcam.v13i4.2 [doi]
AB  - BACKGROUND: Diabetic polyphagia has been associated with elevated plasma ghrelin 
      levels in experimental type 1 diabetes. This increase in food consumption
      contributes to chronic hyperglycaemia in diabetes thus contributing to the
      development of micro- and macrovascular complications. We have reported that
      plant-derived oleanolic acid (OA) and maslinic acid (MA) reduce blood glucose
      levels, in part, through the inhibition of intestinal carbohydrate hydrolyzing
      enzymes and glucose transporters. However, their effects on food intake and
      plasma ghrelin concentrations are unclear. Accordingly, we investigated the
      effects of these triterpenes on food intake and ghrelin expression in
      streptozotocin-induced diabetic rats. MATERIAL: The effects of OA and MA on blood
      glucose concentration; food and water intake were monitored over five weeks after
      which plasma ghrelin concentrations were measured. Additionally, the expression
      of ghrelin in the various sections of the GIT was determined using Western blot
      analysis. RESULTS: Ghrelin concentrations in untreated STZ-induced diabetic rats 
      were significantly higher in comparison to the non-diabetic control.
      Interestingly, the administration of OA and MA reduced food intake, blood glucose
      levels and plasma ghrelin levels in STZ-induced diabetic rats. This was further
      complemented by significant reductions in the gastrointestinal expression of
      ghrelin suggesting that the anti-diabetic properties of these triterpenes are
      mediated, in part, through the reduction of food intake and the modulation of
      ghrelin expression. CONCLUSION: The findings of the study suggest that the
      control of food intake through the reduction of ghrelin expression by
      plant-derived OA and MA may constitute an avenue of glycaemic control in diabetes
      mellitus.
FAU - Luvuno, Mluleki
AU  - Luvuno M
AD  - Department of Human Physiology, School of Laboratory Medicine and Medical
      Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South 
      Africa.
FAU - Mbongwa, Hlengiwe Prosperity
AU  - Mbongwa HP
AD  - Department of Human Physiology, School of Laboratory Medicine and Medical
      Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South 
      Africa.
FAU - Khathi, Andile
AU  - Khathi A
AD  - Department of Human Physiology, School of Laboratory Medicine and Medical
      Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South 
      Africa.
LA  - eng
PT  - Journal Article
DEP - 20160703
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
RN  - 0 (Blood Glucose)
RN  - 0 (Ghrelin)
RN  - 0 (Plant Extracts)
RN  - 0 (Triterpenes)
RN  - 4373-41-5 (maslinic acid)
RN  - 6SMK8R7TGJ (Oleanolic Acid)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - Diabetes Mellitus, Experimental/*diagnostic
      imaging/genetics/metabolism/physiopathology
MH  - Eating
MH  - Gastrointestinal Tract/drug effects/*metabolism
MH  - Ghrelin/genetics/*metabolism
MH  - Humans
MH  - Male
MH  - Oleanolic Acid/administration & dosage/chemistry
MH  - Plant Extracts/*administration & dosage/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Syzygium/*chemistry
MH  - Triterpenes/*administration & dosage/chemistry
PMC - PMC5566155
OTO - NOTNLM
OT  - Syzygium aromaticum
OT  - diabetes mellitus
OT  - ghrelin
OT  - maslinic acid
OT  - oleanolic acid
OT  - triterpenes
EDAT- 2017/08/31 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/08/31 06:00
AID - 10.21010/ajtcam.v13i4.2 [doi]
AID - AJTCAM-13-8 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):8-14. doi:
      10.21010/ajtcam.v13i4.2. eCollection 2016.