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IN VIVO AND IN VITRO IMMUNOMODULATORY AND ANTI-INFLAMMATORY EFFECTS OF TOTAL FLAVONOIDS OF ASTRAGALUS.

Abstract Astragali Radix has long been used to improve immune function in traditional Chinese medicine. However, its main active components and potential immunomodulatory or anti-inflammatory activities have not been elucidated. In the present study, the immunomodulatory and anti-inflammatory activities of total flavonoids of Astragalus (TFA) isolated from Astragali Radix were evaluated by using in vivo animal models and in vitro cell models.
PMID
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Authors

Mayor MeshTerms
Keywords

Anti-inflammation

Immunomodulation

In vitro

In vivo

Total flavonoids of Astragalus (TFA)

Journal Title african journal of traditional, complementary, and alternative medicines : ajtcam
Publication Year Start




PMID- 28852721
OWN - NLM
STAT- MEDLINE
DA  - 20170830
DCOM- 20170908
LR  - 20170908
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 13
IP  - 4
DP  - 2016
TI  - IN VIVO AND IN VITRO IMMUNOMODULATORY AND ANTI-INFLAMMATORY EFFECTS OF TOTAL
      FLAVONOIDS OF ASTRAGALUS.
PG  - 60-73
LID - 10.21010/ajtcam.v13i4.10 [doi]
AB  - BACKGROUND: Astragali Radix has long been used to improve immune function in
      traditional Chinese medicine. However, its main active components and potential
      immunomodulatory or anti-inflammatory activities have not been elucidated. In the
      present study, the immunomodulatory and anti-inflammatory activities of total
      flavonoids of Astragalus (TFA) isolated from Astragali Radix were evaluated by
      using in vivo animal models and in vitro cell models. MATERIALS AND METHODS: The 
      in vivo Immunomodulatory and anti-inflammatory activities of TFA were assessed by
      measuring macrophage phagocytic index, delayed type hypersensitivity, serum
      hemolysin level and immune organ index in mice, ear edema test in mice, paw edema
      test in rats, vascular permeability test in mice and granuloma test in rats. The 
      in vitro Immunomodulatory and anti-inflammatory activities of TFA were assessed
      by examining its effect on cytokine and mediator production in un-stimulated and 
      LPS-stimulated murine RAW 264.7 macrophages. RESULTS: The results of in vivo
      experiments showed that TFA enhanced macrophage phagocytic index, delayed type
      hypersensitivity, serum hemolysin level and immune organ index in mice, and
      attenuated mouse ear edema, rat paw edema, mouse vascular permeability and rat
      granuloma formation. The results of in vitro experiments showed that TFA
      stimulated the production of NO and cytokine TNF-alpha, IL-Iotabeta, IL-6 and
      IFN-gamma in un-stimulated RAW 264.7 macrophages, and inhibited the
      overproduction of these inflammatory mediators in LPS-stimulated RAW 264.7
      macrophages in a dose-dependent manner without exerting cytotoxicity. CONCLUSION:
      These results of this study indicate that TFA have potential immunostimulatory
      and anti-inflammatory effects.
FAU - Guo, Ze
AU  - Guo Z
AD  - Department of Animal Medicine, Agricultural College of Yanbian University,
      Gongyuan Street, Yanji, Jilin 133002, China.
FAU - Xu, Hong-Yan
AU  - Xu HY
AD  - Department of Animal Medicine, Agricultural College of Yanbian University,
      Gongyuan Street, Yanji, Jilin 133002, China.
FAU - Xu, Lu
AU  - Xu L
AD  - Department of Animal Medicine, Agricultural College of Yanbian University,
      Gongyuan Street, Yanji, Jilin 133002, China.
FAU - Wang, Sha-Sha
AU  - Wang SS
AD  - Department of Animal Medicine, Agricultural College of Yanbian University,
      Gongyuan Street, Yanji, Jilin 133002, China.
FAU - Zhang, Xue-Mei
AU  - Zhang XM
AD  - Department of Animal Medicine, Agricultural College of Yanbian University,
      Gongyuan Street, Yanji, Jilin 133002, China.
LA  - eng
PT  - Journal Article
DEP - 20160703
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Flavonoids)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Astragalus Plant/*chemistry
MH  - Edema/*drug therapy/genetics/immunology
MH  - Flavonoids/*administration & dosage
MH  - Humans
MH  - Interleukin-6/genetics/immunology
MH  - Macrophages/drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/*administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
PMC - PMC5566160
OTO - NOTNLM
OT  - Anti-inflammation
OT  - Immunomodulation
OT  - In vitro
OT  - In vivo
OT  - Total flavonoids of Astragalus (TFA)
EDAT- 2017/08/31 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/08/31 06:00
AID - 10.21010/ajtcam.v13i4.10 [doi]
AID - AJTCAM-13-60 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):60-73. doi:
      10.21010/ajtcam.v13i4.10. eCollection 2016.