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EVALUATION THE EXPRESSION OF THREE GENES TO EPITHELIAL OVARIAN CANCER RISK IN CHINESE POPULATION.

Abstract Ovarian cancer is associated with poor survival, because patients are diagnosed at an advanced stage of the disease, and in addition, tumors develop chemoresistance, which carries a poor prognosis for the patient.
PMID
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Authors

Mayor MeshTerms
Keywords

Expression

Gene

Ovarian cancers

SDF-1

Journal Title african journal of traditional, complementary, and alternative medicines : ajtcam
Publication Year Start




PMID- 28852723
OWN - NLM
STAT- MEDLINE
DA  - 20170830
DCOM- 20170908
LR  - 20170908
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 13
IP  - 4
DP  - 2016
TI  - EVALUATION THE EXPRESSION OF THREE GENES TO EPITHELIAL OVARIAN CANCER RISK IN
      CHINESE POPULATION.
PG  - 81-87
LID - 10.21010/ajtcam.v13i4.12 [doi]
AB  - BACKGROUND: Ovarian cancer is associated with poor survival, because patients are
      diagnosed at an advanced stage of the disease, and in addition, tumors develop
      chemoresistance, which carries a poor prognosis for the patient. MATERIAL AND
      METHODS: We hypothesize that high expression of SDF-1, survivin and smac is
      associated with ovarian cancers development and could be used as a biomarker to
      identify this disease. The expressions of SDF-1, survivin and smac in normal
      ovarian (NO) tissue, benign tumor (BT) tissue and epithelial ovarian cancer (EOC)
      tissue were immunohistochemically analysed. RESULTS: Positive expressions of
      SDF-1, survivin and smac were significantly higher in EOC tissue than those in NO
      and BT tissues. SDF-1 expressions were significantly more weaker in advanced
      ovarian carcinomas (FIGO stage III-IV), and in high-grade carcinomas. There was a
      positive correlation between EOC patients with lymph node metastasis and with
      ascites and SDF-1 positivity (P < 0.05). Survivin expressions were significantly 
      more stronger in advanced ovarian carcinomas (FIGO stage III-IV), and in
      high-grade carcinomas. There was a positive correlation between EOC patients with
      lymph node metastasis and with ascites and surviving positivity (P < 0.05). Smac 
      expressions were significantly more stronger in advanced ovarian carcinomas (FIGO
      stage III-IV), and in high-grade carcinomas. There was a positive correlation
      between EOC patients with lymph node metastasis and with ascites and smac
      positivity (P < 0.05). CONCLUSION: These results indicate that SDF-1, surviving
      and smac are closely associated with EOC metastasis.
FAU - Huang, Ju
AU  - Huang J
AD  - Department of Gynaecology, The First Affiliated Hospital of Shantou University
      Medical College, Shantou, PR China.
FAU - Lin, Hao
AU  - Lin H
AD  - Department of Urology, The First Affiliated Hospital, Sun Yat-sen University.
FAU - En Lin, Ming
AU  - En Lin M
AD  - Department of Urology, The First Affiliated Hospital of Shantou University
      Medical College, Shantou, PR China.
LA  - eng
PT  - Journal Article
DEP - 20160703
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (DIABLO protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - Ovarian epithelial cancer
SB  - IM
MH  - Asian Continental Ancestry Group/genetics
MH  - Biomarkers, Tumor/genetics/metabolism
MH  - Chemokine CXCL12/*genetics/metabolism
MH  - China
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins/*genetics/metabolism
MH  - Intracellular Signaling Peptides and Proteins/*genetics/metabolism
MH  - Mitochondrial Proteins/*genetics/metabolism
MH  - Neoplasm Metastasis
MH  - Neoplasms, Glandular and Epithelial/*genetics/metabolism/pathology
MH  - Ovarian Neoplasms/*genetics/metabolism/pathology
PMC - PMC5566156
OTO - NOTNLM
OT  - Expression
OT  - Gene
OT  - Ovarian cancers
OT  - SDF-1
EDAT- 2017/08/31 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/08/31 06:00
AID - 10.21010/ajtcam.v13i4.12 [doi]
AID - AJTCAM-13-81 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):81-87. doi:
      10.21010/ajtcam.v13i4.12. eCollection 2016.