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METABOLIC EFFECTS OF TULBAGHIA VIOLACEA HARV. IN A DIABETIC MODEL.

Abstract Diabetes mellitus (DM) is a cluster of metabolic diseases with chronic hyperglycemia as a defining feature, associated with long-term organ damage and dysfunction. In this study we examined the effect of Tulbaghia violacea rhizome methanolic extract on blood glucose and lipids in normal and streptozotocin-induced diabetic rats.
PMID
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Authors

Mayor MeshTerms
Keywords

STZ-induced diabetic rats

Tulbaghia violacea

hypoglycemic activity

Journal Title african journal of traditional, complementary, and alternative medicines : ajtcam
Publication Year Start




PMID- 28852727
OWN - NLM
STAT- MEDLINE
DA  - 20170830
DCOM- 20170908
LR  - 20170908
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 13
IP  - 4
DP  - 2016
TI  - METABOLIC EFFECTS OF TULBAGHIA VIOLACEA HARV. IN A DIABETIC MODEL.
PG  - 113-122
LID - 10.21010/ajtcam.v13i4.16 [doi]
AB  - BACKGROUND: Diabetes mellitus (DM) is a cluster of metabolic diseases with
      chronic hyperglycemia as a defining feature, associated with long-term organ
      damage and dysfunction. In this study we examined the effect of Tulbaghia
      violacea rhizome methanolic extract on blood glucose and lipids in normal and
      streptozotocin-induced diabetic rats. MATERIALS AND METHODS: Male Wistar rats
      (250-300g) were injected intraperitoneally (i.p.) with streptozotocin (60mg/kg
      body weight) to induce diabetes; or provided with distilled water for the control
      (CON) (3 ml/kg/b.w.) animals and treatment with TVL (60mg/kg.b.w). The rats were 
      divided into 5 groups of 6 animals per group as follows: Non-diabetic control
      (NDC)-received distilled water (3ml/kg.b.w), Non-diabetic TVL (ND+TVL)-received
      TVL (60mh/kg b.w), Diabetic control (DC)-received distilled water (3ml/kg.b.w),
      Diabetic experimental (D+TVL)-received TVL (60mg/kg.b.w), Diabetic experimental
      (D+M)-received Metformin (250 mg/kg.b.w). All doses were administered daily via
      oral gavage. RESULTS: TVL-treated animals showed reduced blood glucose, increased
      plasma insulin, reduced plasma TG, TC, VLDL and increased HDL. Furthermore we
      found decreased thiobarbituric acid reactive substances (TBARS) and increased
      superoxide dismutase (SOD) activity and nitric oxide significantly. Regarding
      renal parameters we found increased blood urea nitrogen (BUN), and improved renal
      morphology in TVL-treated animals. CONCLUSION: Tulbaghia violacea has a
      hypoglycaemic effect which could due to its effects on multiple pathways of the
      hyperglycemic process. Further work is needed to identify the mechanism of its
      antidiabetic effect.
FAU - Moodley, Kogi
AU  - Moodley K
AD  - Discipline of Human Physiology, School of Laboratory Medicine and Medical
      Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag
      X54001, Durban 4000, South Africa.
FAU - Mackraj, Irene
AU  - Mackraj I
AD  - Discipline of Human Physiology, School of Laboratory Medicine and Medical
      Sciences, College of Health Sciences, University of KwaZulu-Natal, Private Bag
      X54001, Durban 4000, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20160703
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (Plant Extracts)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Amaryllidaceae/*chemistry
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus/*drug therapy/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage
MH  - Insulin/metabolism
MH  - Male
MH  - Oxidative Stress/drug effects
MH  - Plant Extracts/*administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
PMC - PMC5566134
OTO - NOTNLM
OT  - STZ-induced diabetic rats
OT  - Tulbaghia violacea
OT  - hypoglycemic activity
EDAT- 2017/08/31 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/08/31 06:00
AID - 10.21010/ajtcam.v13i4.16 [doi]
AID - AJTCAM-13-113 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):113-122. doi:
      10.21010/ajtcam.v13i4.16. eCollection 2016.