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HEXANE EXTRACT OF Dacryodes edulis FRUITS POSSESSES ANTI-DIABETIC AND HYPOLIPIDAEMIC POTENTIALS IN ALLOXAN DIABETES OF RATS.

Abstract The fruit extract of Dacryodes edulis (D. edulis), the African pear or plum, a tree indigenous to the humid tropics has been used for managing wounds, skin diseases, sickle cell anaemia, dysentery and fever in some African nations. In South Eastern Nigeria, 'herbal doctors' include its marshed fruit in decoctions administered to diabetic patients. However no scientific substantiation of their claim and use exist in literature. Hence, the need to evaluate the antidiabetic and hypolipidaemic activity of hexane extracts of D. edulis fruit in alloxanised animal model.
PMID
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Authors

Mayor MeshTerms
Keywords

Dacryodes edulis

anti-diabetic

diabetes

hypolipidaemic

Journal Title african journal of traditional, complementary, and alternative medicines : ajtcam
Publication Year Start




PMID- 28852729
OWN - NLM
STAT- In-Process
DA  - 20170830
LR  - 20170830
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 13
IP  - 4
DP  - 2016
TI  - HEXANE EXTRACT OF Dacryodes edulis FRUITS POSSESSES ANTI-DIABETIC AND
      HYPOLIPIDAEMIC POTENTIALS IN ALLOXAN DIABETES OF RATS.
PG  - 132-144
LID - 10.21010/ajtcam.v13i4.18 [doi]
AB  - BACKGROUND: The fruit extract of Dacryodes edulis (D. edulis), the African pear
      or plum, a tree indigenous to the humid tropics has been used for managing
      wounds, skin diseases, sickle cell anaemia, dysentery and fever in some African
      nations. In South Eastern Nigeria, 'herbal doctors' include its marshed fruit in 
      decoctions administered to diabetic patients. However no scientific
      substantiation of their claim and use exist in literature. Hence, the need to
      evaluate the antidiabetic and hypolipidaemic activity of hexane extracts of D.
      edulis fruit in alloxanised animal model. MATERIALS AND METHODS: Sub-toxic doses 
      between 400 and 1600mg/kg were orally administered sub-chronically to
      alloxan-induced diabetic rats for 15 days and compared to glibenclamide
      (2.5mg/kg). The glycaemia levels, body weights, lipid profile, blood urea,
      creatinine and liver enzyme levels were measured. Basic histology of the
      pancreatic tissue was also performed to examine the effects on the pancreas as
      possible mechanistic lead. RESULTS: Oral acute dosing of D. edulis hexane extract
      decreased blood glucose levels, while sub-chronic treatment of the extract
      down-regulated significantly hyperglycaemia, total cholesterol, triglycerides,
      LDL-C, ALT and ALP levels. However, the HDL-C levels increased significantly.
      Histopathological examination of the pancreatic tissues after sub-chronic
      treatment showed that glibenclamide and the highest dose of the extract 1600mg/kg
      restored the afore-damaged pancreatic beta-cell architecture. CONCLUSION: Our
      findings portend that D. edulis hexane fruit extract possesses hypoglycaemic and 
      hypolipidaemic activities as well as restoration of the pancreatic architecture
      without any obvious untoward hepatic damages, suggesting that its use in the
      management of the diabetes may be valid. List of Non-standard abbreviations:D.
      edulis = dacryode edulis, DEnH = Dacryodes edulis n-hexane fruit extract, B.wt. =
      Body weight, Per os = Oral administration, NC = normal control, DC =Diabetic
      control, SC = Standard control, LDL-C = low density lipoprotein cholesterol,
      HDL-C = High density lipoprotein cholesterol, TG = Triglyceride, TC = Total
      cholesterol.
FAU - Okolo, Chidinma A
AU  - Okolo CA
AD  - Physiology Unit, Department of Zoology and Environmental Biology, Faculty of
      Biological Sciences, University of Nigeria, Nsukka, Enugu State. 410001, Nigeria.
AD  - Department of Physiology, Otago School of Medical Science, University of Otago,
      Dunedin, 9016, New Zealand.
FAU - Ejere, Vincent C
AU  - Ejere VC
AD  - Physiology Unit, Department of Zoology and Environmental Biology, Faculty of
      Biological Sciences, University of Nigeria, Nsukka, Enugu State. 410001, Nigeria.
FAU - Chukwuka, Christian O
AU  - Chukwuka CO
AD  - Department of Biology and Biotechnology, Federal University Ndufu-Alike Ikwo, PMB
      1010 Abakiliki, Ebonyi State Nigeria.
FAU - Ezeigbo, Ihechiluru I
AU  - Ezeigbo II
AD  - Department of Veterinary Physiology, Biochemistry and Pharmacology, Michael
      Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Nigeria.
AD  - Department of Comparative Biomedical Sciences, Royal Veterinary College,
      University of London, Royal College Street, London, NW1 0TU, UK.
FAU - Nwibo, Daniel D
AU  - Nwibo DD
AD  - Department of Pure and Industrial Chemistry, University of Nigeria, Nsukka
      410001, Nigeria.
AD  - Laboratory of Pharmaceutical, Microbial and Medicinal Chemistry, Graduate School 
      of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo,
      113-0033 Japan.
FAU - Okorie, Augustine N
AU  - Okorie AN
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences,
      University of Nigeria, Nsukka 410001, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20160703
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
PMC - PMC5566136
OTO - NOTNLM
OT  - Dacryodes edulis
OT  - anti-diabetic
OT  - diabetes
OT  - hypolipidaemic
EDAT- 2017/08/31 06:00
MHDA- 2017/08/31 06:00
CRDT- 2017/08/31 06:00
AID - 10.21010/ajtcam.v13i4.18 [doi]
AID - AJTCAM-13-132 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):132-144. doi:
      10.21010/ajtcam.v13i4.18. eCollection 2016.