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SALVIANOLIC ACID B ALLEVIATING MYOCARDIUM INJURY IN ISCHEMIA REPERFUSION RATS.

Abstract Salvia miltiorrhiza (SM) Bunge is one of the widely-used Chinese medicinal herbs. Salvianolic acid B (Sal B), a bioactive compound isolated from the Chinese herb Radix Salviae Miltiorrhizae, has been reported to exhibit anti-inflammatory and anti-oxidantive effects.
PMID
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Authors

Mayor MeshTerms
Keywords

Antioxidant

Immunity

Rat

Journal Title african journal of traditional, complementary, and alternative medicines : ajtcam
Publication Year Start




PMID- 28852731
OWN - NLM
STAT- In-Process
DA  - 20170830
LR  - 20170830
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 13
IP  - 4
DP  - 2016
TI  - SALVIANOLIC ACID B ALLEVIATING MYOCARDIUM INJURY IN ISCHEMIA REPERFUSION RATS.
PG  - 157-161
LID - 10.21010/ajtcam.v13i4.20 [doi]
AB  - BACKGROUND: Salvia miltiorrhiza (SM) Bunge is one of the widely-used Chinese
      medicinal herbs. Salvianolic acid B (Sal B), a bioactive compound isolated from
      the Chinese herb Radix Salviae Miltiorrhizae, has been reported to exhibit
      anti-inflammatory and anti-oxidantive effects. MATERIAL AND METHOD: To study the 
      cardioprotective effects of salvianolic acid B (Sal B) on acute myocardial
      ischemia reperfusion (MIR) injury rats, on the basis of this investigation, the
      possible mechanism of salvianolic acid B was elucidated. Male Sprague- Dawley
      rats (200-220 g) were randomly divided into five groups: sham-operated, MIR, MIR 
      + Sal B (10 mg/kg/day, orally), MIR + Sal B (20 mg/kg/ day, orally) and MIR + Sal
      B (30 mg/kg/ day, orally). Before operation, the foregoing groups were pretreated
      with homologous drug once a day for 7 days, respectively. After twelve hours in
      MIR, the cardioprotective effects of SPJ were evaluated by infarct size,
      biochemical values, and the antioxidative and antiapoptotic relative gene
      expressions. RESULTS: Sal B significantly improved heart function and decreased
      infarct size; remarkably decreased levels of serum TNF-alpha and IL-Iotabeta
      levels, increased contents of myocardium antioxidant enzymes activities; western 
      blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins
      expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax.
      CONCLUSION: In ischemic myocardium, oxidative stress caused the overgeneration
      and accumulation of reactive oxygen species (ROS), which was central of cardiac
      ischemic injury. Sal B exerted beneficially cardioprotective effects on
      myocardial ischemia injury rats, mainly scavenging oxidative stress-triggered
      overgeneration and accumulation of ROS, alleviating myocardial ischemia injury
      and cardiac cell death. List of abbreviations: salvianolic acid B (Sal B);
      myocardial ischemia reperfusion (MIR); reactive oxygen species (ROS); Left
      ventricular end-diastolic pressure (LVEDP); left ventricular end-diastolic volume
      (LVEDV); Malondialdehyde (MDA); superoxide dismutase (SOD); catalase (CAT);
      Glutathione peroxidase (GSH-Px); glutathione reductase (GR).
FAU - Qiao, Zengyong
AU  - Qiao Z
AD  - Department of Cardiovascular Medicine, The 10 people hospital affiliated to
      TongJi Medical University, Shanghai, China.
FAU - Xu, Yawei
AU  - Xu Y
AD  - Department of Cardiovascular Medicine, The 10 people hospital affiliated to
      TongJi Medical University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20160703
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
PMC - PMC5566139
OTO - NOTNLM
OT  - Antioxidant
OT  - Immunity
OT  - Rat
EDAT- 2017/08/31 06:00
MHDA- 2017/08/31 06:00
CRDT- 2017/08/31 06:00
AID - 10.21010/ajtcam.v13i4.20 [doi]
AID - AJTCAM-13-157 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):157-161. doi:
      10.21010/ajtcam.v13i4.20. eCollection 2016.