PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

ANTI-INFLAMMATORY ACTIVITY OF PLATYCODIN D ON ALCOHOL-INDUCED FATTY LIVER RATS VIA TLR4-MYD88-NF-κB SIGNAL PATH.

Abstract The current study was designed to evaluate the effect of Platycodin D (PD), triterpenoid saponins extracted from the roots of Platycodon grandiflorum (PG) on alcohol-induced fatty liver (AFL) and investigate the possible mechanism.
PMID
Related Publications

Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll-like receptor 4 (TLR4) or TLR2 mRNA expression.

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.

Platycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1.

Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway.

Effects of traditional chinese medicine on endotoxin and its receptors in rats with non-alcoholic steatohepatitis.

Authors

Mayor MeshTerms
Keywords

Platycodin D

alcoholic

anti-inflammation

fatty liver

toll-like receptor 4

Journal Title african journal of traditional, complementary, and alternative medicines : ajtcam
Publication Year Start




PMID- 28852734
OWN - NLM
STAT- MEDLINE
DA  - 20170830
DCOM- 20170908
LR  - 20170908
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 13
IP  - 4
DP  - 2016
TI  - ANTI-INFLAMMATORY ACTIVITY OF PLATYCODIN D ON ALCOHOL-INDUCED FATTY LIVER RATS
      VIA TLR4-MYD88-NF-kappaB SIGNAL PATH.
PG  - 176-183
LID - 10.21010/ajtcam.v13i4.23 [doi]
AB  - BACKGROUND: The current study was designed to evaluate the effect of Platycodin D
      (PD), triterpenoid saponins extracted from the roots of Platycodon grandiflorum
      (PG) on alcohol-induced fatty liver (AFL) and investigate the possible mechanism.
      METHODS AND MATERIALS: A rat model was set up by feeding ethanol and fish oil to 
      experimental rats, which then were treated with PD of 10, 20, 30 mg/kg body
      weight/day for 4 weeks, respectively, whereafter, liver function enzymes,
      endotoxin of serum and liver lipid were assayed by biochemical methods,
      cytokines, histochemistry of hepatic tissue, the protein expression of CD14 and
      TLR4, the mRNA expression of MD-2, MyD 88 and TRAF-6 were assayed. RESULTS:
      Treatment with PD on AFL rats significantly decreased the levels of serum ALT,
      AST and TBIL, coefficient of liver index and the hepatic tissue contents of TG,
      additionally and dramatically decreased serum endotoxin levels, down-regulated
      MD-2 and CD14 levels, as well as the mRNA expression of TLR4, MyD88 and TRAF-6,
      accordingly suppressed NF-kappaB: p65 as well as endotoxin-mediated inflammatory 
      factors such as TNF-alpha and IL-6. CONCLUSIONS: Treatment with PD effectively
      protects against AFL through anti-inflammatory and anti-endotoxic process, and
      the confirmed mechanism is that PD treatment ameliorate alcoholic-induced liver
      injury mainly via TLR4-MyD88-NF-K: B signal path in AFL rat. List of
      Abbreviations: AFL: alcoholic-induced fatty liver, CD14: cluster of
      differentiation 14, LPS: lipopolysaccharide, LBP: lipopolysaccharide-binding
      protein, TLR4: toll-like receptor 4, MD-2: molecule myeloid differential
      protein-2, MyD 88: myeloid differentiation primary response protein 88, TRAF-6:
      TNF-receptor associated factor-6, NF-kappaB: nuclear transcription factor kappa
      B, IL-6: interleukin-6, TNF-alpha: tumor necrosis factor-alpha, PG: Platycodon
      grandiflorum, PD: Platycodin D.
FAU - Wu, Jing-Tao
AU  - Wu JT
AD  - Department of science and technology.
FAU - Yang, Gui-Wen
AU  - Yang GW
AD  - College of life science, Shandong normal university, Jinan 250014, China.
FAU - Qi, Cui-Hua
AU  - Qi CH
AD  - Department of food science and nutrition, University of Jinan, Jinan 250022,
      China.
FAU - Zhou, Lei
AU  - Zhou L
AD  - College of biological science and technology, University of Jinan, Jinan 250022, 
      China.
FAU - Hu, Jian-Guo
AU  - Hu JG
AD  - Department of food science and nutrition, University of Jinan, Jinan 250022,
      China.
FAU - Wang, Mao-Shan
AU  - Wang MS
AD  - Department of food science and nutrition, University of Jinan, Jinan 250022,
      China.
LA  - eng
PT  - Journal Article
DEP - 20160703
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
RN  - 0 (Alcohols)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Saponins)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Triterpenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - CWJ06TA2GI (platycodin D)
SB  - IM
MH  - Alcohols/*adverse effects
MH  - Animals
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Fatty Liver/chemically induced/*drug therapy/genetics/metabolism
MH  - Humans
MH  - Interleukin-6/genetics/metabolism
MH  - Male
MH  - NF-kappa B/genetics/*metabolism
MH  - Plant Roots/chemistry
MH  - Platycodon/*chemistry
MH  - Rats
MH  - Saponins/*administration & dosage
MH  - Signal Transduction/drug effects
MH  - Toll-Like Receptor 4/genetics/*metabolism
MH  - Triterpenes/*administration & dosage
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
PMC - PMC5566142
OTO - NOTNLM
OT  - Platycodin D
OT  - alcoholic
OT  - anti-inflammation
OT  - fatty liver
OT  - toll-like receptor 4
COI - Conflict of interest The authors have no conflicts of interest to declare.
EDAT- 2017/08/31 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/08/31 06:00
AID - 10.21010/ajtcam.v13i4.23 [doi]
AID - AJTCAM-13-176 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):176-183. doi:
      10.21010/ajtcam.v13i4.23. eCollection 2016.