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KAEMPFEROL, A FLAVONOID COMPOUND FROM GYNURA MEDICA INDUCED APOPTOSIS AND GROWTH INHIBITION IN MCF-7 BREAST CANCER CELL.

Abstract Kaempferol, a natural flavonoid, has been shown to induce cancer cell apoptosis and cell growth inhibition in several tumors. Previously we have conducted a full investigation on the chemical constituents of Gynura medica, kaempferol and its glycosides are the major constituents of G. medica. Here we investigated the growth inhibition and apoptosis induction effect of kaempferol extracted from G. medica.
PMID
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Authors

Mayor MeshTerms
Keywords

Apoptosis

Breast Cancer

Kaempferol

Journal Title african journal of traditional, complementary, and alternative medicines : ajtcam
Publication Year Start




PMID- 28852738
OWN - NLM
STAT- MEDLINE
DA  - 20170830
DCOM- 20170908
LR  - 20170908
IS  - 2505-0044 (Electronic)
IS  - 2505-0044 (Linking)
VI  - 13
IP  - 4
DP  - 2016
TI  - KAEMPFEROL, A FLAVONOID COMPOUND FROM GYNURA MEDICA INDUCED APOPTOSIS AND GROWTH 
      INHIBITION IN MCF-7 BREAST CANCER CELL.
PG  - 210-215
LID - 10.21010/ajtcam.v13i4.27 [doi]
AB  - BACKGROUND: Kaempferol, a natural flavonoid, has been shown to induce cancer cell
      apoptosis and cell growth inhibition in several tumors. Previously we have
      conducted a full investigation on the chemical constituents of Gynura medica,
      kaempferol and its glycosides are the major constituents of G. medica. Here we
      investigated the growth inhibition and apoptosis induction effect of kaempferol
      extracted from G. medica. MATERIALS AND METHODS: The inhibition effects of
      kaempferol were evaluated by MTS assay and soft agar colony formation assay.
      Fluorescence staining and western blotting were be used to study the apoptosis.
      The structure was identified by 1H- NMR), 13C-NMR and ESI-MS analyses. RESULTS:
      Our results showed that kaempferol's inhibition of MCF-7 breast cancer cell
      growth may through inducing apoptosis and downregulation of Bcl2 expression.
      CONCLUSION: Kaempferol is a promising cancer preventive and therapeutic agent for
      breast cancer. List of non-standard abbreviations: MTS:
      3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetr
      azolium, HPLC: High-performance liquid chromatography, NMR: Nuclear Magnetic
      Resonance, ESI-MS Electrospray Ionization Mass Spectral, PARP: Poly ADP-ribose
      polymerase.
FAU - Yi, Xiaofang
AU  - Yi X
AD  - The First College of Clinical Medical Science, China Three Gorges University,
      Yichang 443003, Hubei, China.
FAU - Zuo, Jiangcheng
AU  - Zuo J
AD  - Yiling maternity and child health care hospital, Yichang 443003, Hubei, China.
FAU - Tan, Chao
AU  - Tan C
AD  - The First College of Clinical Medical Science, China Three Gorges University,
      Yichang 443003, Hubei, China.
FAU - Xian, Sheng
AU  - Xian S
AD  - The First College of Clinical Medical Science, China Three Gorges University,
      Yichang 443003, Hubei, China.
FAU - Luo, Chunhua
AU  - Luo C
AD  - The First College of Clinical Medical Science, China Three Gorges University,
      Yichang 443003, Hubei, China.
FAU - Chen, Sai
AU  - Chen S
AD  - The First College of Clinical Medical Science, China Three Gorges University,
      Yichang 443003, Hubei, China.
FAU - Yu, Liangfang
AU  - Yu L
AD  - The First College of Clinical Medical Science, China Three Gorges University,
      Yichang 443003, Hubei, China.
FAU - Luo, Yucheng
AU  - Luo Y
AD  - The First College of Clinical Medical Science, China Three Gorges University,
      Yichang 443003, Hubei, China.
LA  - eng
PT  - Journal Article
DEP - 20160703
PL  - Nigeria
TA  - Afr J Tradit Complement Altern Med
JT  - African journal of traditional, complementary, and alternative medicines : AJTCAM
JID - 101232990
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Kaempferols)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 731P2LE49E (kaempferol)
SB  - IM
MH  - Antineoplastic Agents, Phytogenic/chemistry/*pharmacology
MH  - Apoptosis/*drug effects
MH  - Asteraceae/*chemistry
MH  - Breast Neoplasms/drug therapy/genetics/metabolism/*physiopathology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/*drug effects
MH  - Drugs, Chinese Herbal/chemistry/*pharmacology
MH  - Humans
MH  - Kaempferols/chemistry/*pharmacology
MH  - MCF-7 Cells
MH  - Proto-Oncogene Proteins c-bcl-2/genetics/metabolism
PMC - PMC5566146
OTO - NOTNLM
OT  - Apoptosis
OT  - Breast Cancer
OT  - Kaempferol
EDAT- 2017/08/31 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/08/31 06:00
AID - 10.21010/ajtcam.v13i4.27 [doi]
AID - AJTCAM-13-210 [pii]
PST - epublish
SO  - Afr J Tradit Complement Altern Med. 2016 Jul 3;13(4):210-215. doi:
      10.21010/ajtcam.v13i4.27. eCollection 2016.