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IgM as a novel predictor of disease progression in secondary focal segmental glomerulosclerosis.

Abstract To determine the role of immunoglobulin M (IgM) deposits in clinical manifestations, disease outcome, and treatment response of idiopathic and secondary focal segmental glomerulosclerosis (FSGS).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title croatian medical journal
Publication Year Start




PMID- 28857521
OWN - NLM
STAT- MEDLINE
DA  - 20170831
DCOM- 20170907
LR  - 20170907
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Linking)
VI  - 58
IP  - 4
DP  - 2017 Aug 31
TI  - IgM as a novel predictor of disease progression in secondary focal segmental
      glomerulosclerosis.
PG  - 281-291
AB  - AIM: To determine the role of immunoglobulin M (IgM) deposits in clinical
      manifestations, disease outcome, and treatment response of idiopathic and
      secondary focal segmental glomerulosclerosis (FSGS). METHODS: Kidney biopsy
      specimens of 171 patients diagnosed with FSGS (primary and secondary) and 50
      control patients were retrospectively included in the study. For each patient,
      clinical and outcome data were obtained and compared to morphological parameters,
      including immunofluorescence analysis of mesangial IgM and complement 3 (C3)
      deposits analyzed on kidney biopsy samples. RESULTS: There were significant
      positive correlations between IgM and C3 deposition in secondary FSGS (P<0.001)
      and between IgM and mesangial deposits detected by electron microscopy in
      secondary FSGS (P=0.015), which indicated that higher IgM deposition correlated
      with higher C3 deposition and mesangial deposits only in secondary FSGS. Patients
      with secondary FSGS and the deposition of IgM showed inferior renal outcomes at
      earlier time points in comparison with patients with negative IgM expression
      (P=0.022). CONCLUSIONS: We detected a positive correlation between IgM and C3 in 
      secondary FSGS. The association between IgM deposition and worse renal outcome in
      secondary FSGS indicates that IgM may play a role in the progression of this
      disease.
FAU - Pacic, Arijana
AU  - Pacic A
AD  - Arijana Pacic, Department of Pathology and Cytology, Dubrava University Hospital,
      Av. Gojka Suska 6, 10 000 Zagreb, Croatia, [email protected]
FAU - Senjug, Petar
AU  - Senjug P
FAU - Bacalja, Jasna
AU  - Bacalja J
FAU - Tisljar, Miroslav
AU  - Tisljar M
FAU - Horvatic, Ivica
AU  - Horvatic I
FAU - Bulimbasic, Stela
AU  - Bulimbasic S
FAU - Knotek, Mladen
AU  - Knotek M
FAU - Galesic, Kresimir
AU  - Galesic K
FAU - Galesic Ljubanovic, Danica
AU  - Galesic Ljubanovic D
LA  - eng
PT  - Journal Article
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
RN  - 0 (Biomarkers)
RN  - 0 (Complement C3)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/metabolism
MH  - Case-Control Studies
MH  - Complement C3/metabolism
MH  - Disease Progression
MH  - Female
MH  - Glomerulosclerosis, Focal Segmental/*immunology/pathology
MH  - Humans
MH  - Immunoglobulin M/*metabolism
MH  - Kidney/*metabolism/pathology
MH  - Male
MH  - Mesangial Cells/metabolism/pathology
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC5577650
EDAT- 2017/09/01 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/09/01 06:00
PST - ppublish
SO  - Croat Med J. 2017 Aug 31;58(4):281-291.