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Are programmed cell death 1 gene polymorphisms correlated with susceptibility to rheumatoid arthritis?: A meta-analysis.

Abstract Several studies investigated the relationship between programmed cell death 1 (PDCD1) gene polymorphisms and rheumatoid arthritis (RA) risk, but the results were controversial. To explore whether PDCD1 gene polymorphisms have an effect on RA risk, we conducted this meta-analysis to investigate the relationships between PDCD1 polymorphisms (rs36084323 [PD-1.1 G/A], rs11568821 [PD-1.3 G/A] and rs2227981 [PD-1.5 C/T]) and RA risk under 4 genetic models.
PMID
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Authors

Mayor MeshTerms

Genetic Predisposition to Disease

Keywords
Journal Title medicine
Publication Year Start




PMID- 28858091
OWN - NLM
STAT- MEDLINE
DA  - 20170831
DCOM- 20170911
LR  - 20170912
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 35
DP  - 2017 Sep
TI  - Are programmed cell death 1 gene polymorphisms correlated with susceptibility to 
      rheumatoid arthritis?: A meta-analysis.
PG  - e7805
LID - 10.1097/MD.0000000000007805 [doi]
AB  - BACKGROUND: Several studies investigated the relationship between programmed cell
      death 1 (PDCD1) gene polymorphisms and rheumatoid arthritis (RA) risk, but the
      results were controversial. To explore whether PDCD1 gene polymorphisms have an
      effect on RA risk, we conducted this meta-analysis to investigate the
      relationships between PDCD1 polymorphisms (rs36084323 [PD-1.1 G/A], rs11568821
      [PD-1.3 G/A] and rs2227981 [PD-1.5 C/T]) and RA risk under 4 genetic models.
      METHODS: PubMed, EMBASE, Web of Science, Cochrane Library China National
      Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database
      (CBLM) were systematically searched for all eligible case-control studies. The
      last search was updated on September 10, 2016. Studies were accessed using
      Newcastle-Ottawa Scale case control study (NOS), and the combined effect size was
      calculated using STATA software, version 12.0. The pooled odds ratio (OR) with
      95% confidence interval (CI) was calculated to assess the association.
      Heterogeneity analysis and subgroup analysis were also performed. Sensitivity
      analysis and publication bias were also performed if necessary. RESULTS: This
      meta-analysis included 6 studies. The result demonstrated null association
      between rs36084323 (PD-1.1 G/A) polymorphism and RA susceptibility in all 4
      genetic models. With regard to rs11568821 (PD-1.3 G/A), statistically significant
      association with RA risk was observed under allele model in Caucasians (allele
      model A vs G, OR = 1.19, 95% CI = 1.03-1.41). There was no significant
      association between rs2227981 (PD-1.5 C/T) polymorphism and RA risk. CONCLUSION: 
      The present study suggests that mutant A allele in rs11568821 (PD-1.3 G/A) might 
      increase the susceptibility to RA in Caucasians.
FAU - Zou, Yuming
AU  - Zou Y
AD  - aDepartment of Orthopedics, Changhai Hospital, The First Affiliated Hospital of
      the Second Military Medical University bDepartment of Health Toxicology, College 
      of Tropical Medicine and Public Health, Second Military Medical University,
      Shanghai, China.
FAU - Zhang, Ziteng
AU  - Zhang Z
FAU - Liu, Yangang
AU  - Liu Y
FAU - Liu, Denghui
AU  - Liu D
FAU - Xu, Weidong
AU  - Xu W
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
SB  - AIM
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Programmed Cell Death 1 Receptor/*genetics
PMC - PMC5585485
EDAT- 2017/09/01 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/09/01 06:00
AID - 10.1097/MD.0000000000007805 [doi]
AID - 00005792-201709010-00015 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Sep;96(35):e7805. doi: 10.1097/MD.0000000000007805.