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PMID- 28858094
DA  - 20170831
DCOM- 20170911
LR  - 20170912
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 35
DP  - 2017 Sep
TI  - Fatal acute hepatic failure in a family infected with the hepatitis A virus
      subgenotype IB: A case report.
PG  - e7847
LID - 10.1097/MD.0000000000007847 [doi]
AB  - RATIONALE: Hepatitis A viral infection is a well-known cause of subclinical or
      acute self-limited hepatitis. Few cases of hepatitis A virus (HAV)-associated
      acute liver failure (ALF) have been reported in low HAV endemic countries
      annually. PATIENTS CONCERNS: To investigate the possible factors that affected
      the severity of HAV infection, a family cluster infected with the HAV subgenotype
      IB strain, which is not common in Japan, was described. DIAGNOSES: This family
      consisted of five members who all were infected with HAV. INTERVENTIONS: Four of 
      the five patients hospitalized except for an asymptomatic patient. OUTCOMES: Two 
      of the five patients, men in their 50s and 60s, developed ALF, and one patient
      died. Various host factors, including sex (male), age, and a high bilirubin
      level, may affect the outcomes. Based on viral factors, HAV RNA was higher in the
      fatal case compared with others, and it decreased within a short period of time. 
      The similarity of the nucleotide sequences was 99.9% among the HAV isolates based
      on an entire genomic sequence. Deletions and/or insertions on the HAV
      protein-coding sequences that caused a frameshift were found in surviving cases
      but not in the fatal case. LESSONS: The rapid clearance of increased HAV and the 
      absence of defective HAV might be closely associated with the onset of liver
FAU - Yoshida, Yuichi
AU  - Yoshida Y
AD  - aDivision of Hepatology, Department of Internal Medicine, Iwate Medical
      University School of Medicine, Morioka, Iwate bDivision of Virology, Department
      of Infection and Immunity, Jichi Medical University School of Medicine,
      Shimozuke, Tochigi, Japan.
FAU - Okada, Yohei
AU  - Okada Y
FAU - Suzuki, Akiko
AU  - Suzuki A
FAU - Kakisaka, Keisuke
AU  - Kakisaka K
FAU - Miyamoto, Yasuhiro
AU  - Miyamoto Y
FAU - Miyasaka, Akio
AU  - Miyasaka A
FAU - Takikawa, Yasuhiro
AU  - Takikawa Y
FAU - Nishizawa, Tsutomu
AU  - Nishizawa T
FAU - Okamoto, Hiroaki
AU  - Okamoto H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - *Family
MH  - Fatal Outcome
MH  - Female
MH  - Hepatitis A/complications/*diagnosis/virology
MH  - Hepatitis A virus/isolation & purification
MH  - Humans
MH  - Japan
MH  - Liver Failure, Acute/complications/*diagnosis/virology
MH  - Male
MH  - Middle Aged
PMC - PMC5585488
EDAT- 2017/09/01 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/09/01 06:00
AID - 10.1097/MD.0000000000007847 [doi]
AID - 00005792-201709010-00018 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Sep;96(35):e7847. doi: 10.1097/MD.0000000000007847.