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Gametocytemia and Attractiveness of Plasmodium falciparum-Infected Kenyan Children to Anopheles gambiae Mosquitoes.

Abstract It has been suggested that Plasmodia manipulate their vertebrate hosts to enhance parasite transmission. Using a dual-choice olfactometer, we investigated the attraction of Anopheles gambiae to 50 Kenyan children (aged 5-12 years) who were naturally infected with Plasmodium falciparum or noninfected controls. Microscopic gametocyte carriers attracted almost 2 times more mosquitoes than children who were parasite free, harbored asexual stages, or had gametocytes at submicroscopic densities. By using highly sensitive stage-specific molecular methods to detect P. falciparum, we show that gametocytes-and not their noninfectious asexual progenitors-induce increased attractiveness of humans to mosquitoes. Our findings therefore support the parasite host manipulation hypothesis.
PMID
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Authors

Mayor MeshTerms

Feeding Behavior

Plasmodium falciparum

Keywords

chemical ecology

host finding

malaria transmission

olfactory behavior

vector control

Journal Title the journal of infectious diseases
Publication Year Start




PMID- 28859429
OWN - NLM
STAT- MEDLINE
DA  - 20170901
DCOM- 20170907
LR  - 20170907
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 216
IP  - 3
DP  - 2017 Aug 01
TI  - Gametocytemia and Attractiveness of Plasmodium falciparum-Infected Kenyan
      Children to Anopheles gambiae Mosquitoes.
PG  - 291-295
LID - 10.1093/infdis/jix214 [doi]
AB  - It has been suggested that Plasmodia manipulate their vertebrate hosts to enhance
      parasite transmission. Using a dual-choice olfactometer, we investigated the
      attraction of Anopheles gambiae to 50 Kenyan children (aged 5-12 years) who were 
      naturally infected with Plasmodium falciparum or noninfected controls.
      Microscopic gametocyte carriers attracted almost 2 times more mosquitoes than
      children who were parasite free, harbored asexual stages, or had gametocytes at
      submicroscopic densities. By using highly sensitive stage-specific molecular
      methods to detect P. falciparum, we show that gametocytes-and not their
      noninfectious asexual progenitors-induce increased attractiveness of humans to
      mosquitoes. Our findings therefore support the parasite host manipulation
      hypothesis.
CI  - (c) The Author 2017. Published by Oxford University Press for the Infectious
      Diseases Society of America. All rights reserved. For permissions, e-mail:
      [email protected]
FAU - Busula, Annette O
AU  - Busula AO
AD  - Laboratory of Entomology, Wageningen University.
AD  - International Centre of Insect Physiology and Ecology, Nairobi.
FAU - Bousema, Teun
AU  - Bousema T
AD  - Medical Microbiology, Radboud University Medical Centre, Nijmegen, The
      Netherlands.
FAU - Mweresa, Collins K
AU  - Mweresa CK
AD  - International Centre of Insect Physiology and Ecology, Nairobi.
AD  - School of Biological and Physical Sciences, Jaramogi Oginga Odinga University of 
      Science and Technology, Bondo, Kenya.
FAU - Masiga, Daniel
AU  - Masiga D
AD  - International Centre of Insect Physiology and Ecology, Nairobi.
FAU - Logan, James G
AU  - Logan JG
AD  - London School of Hygiene and Tropical Medicine, United Kingdom.
FAU - Sauerwein, Robert W
AU  - Sauerwein RW
AD  - Medical Microbiology, Radboud University Medical Centre, Nijmegen, The
      Netherlands.
FAU - Verhulst, Niels O
AU  - Verhulst NO
AD  - Laboratory of Entomology, Wageningen University.
FAU - Takken, Willem
AU  - Takken W
AD  - Laboratory of Entomology, Wageningen University.
FAU - de Boer, Jetske G
AU  - de Boer JG
AD  - Laboratory of Entomology, Wageningen University.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - AIM
SB  - IM
MH  - Animals
MH  - Anopheles gambiae/parasitology/*physiology
MH  - Child
MH  - Child, Preschool
MH  - *Feeding Behavior
MH  - Female
MH  - Host-Parasite Interactions
MH  - Humans
MH  - Insect Vectors/parasitology/*physiology
MH  - Kenya
MH  - Malaria, Falciparum/parasitology/*transmission
MH  - Male
MH  - Olfactory Perception
MH  - *Plasmodium falciparum
OTO - NOTNLM
OT  - chemical ecology
OT  - host finding
OT  - malaria transmission
OT  - olfactory behavior
OT  - vector control
EDAT- 2017/09/02 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/09/02 06:00
PHST- 2017/02/17 [received]
PHST- 2017/05/02 [accepted]
AID - 3867534 [pii]
AID - 10.1093/infdis/jix214 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Aug 1;216(3):291-295. doi: 10.1093/infdis/jix214.