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Naturally Acquired Immunity Against Rotavirus Infection and Gastroenteritis in Children: Paired Reanalyses of Birth Cohort Studies.

Abstract Observational studies in socioeconomically distinct populations have yielded conflicting conclusions about the strength of naturally acquired immunity against rotavirus gastroenteritis (RVGE), mirroring vaccine underperformance in low-income countries. We revisited birth cohort studies to understand naturally acquired protection against rotavirus infection and RVGE.
PMID
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Authors

Mayor MeshTerms

Adaptive Immunity

Immunity, Innate

Keywords

birth cohort

gastroenteritis

immunity

natural infection

rotavirus

Journal Title the journal of infectious diseases
Publication Year Start




PMID- 28859432
OWN - NLM
STAT- MEDLINE
DA  - 20170901
DCOM- 20170907
LR  - 20170907
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 216
IP  - 3
DP  - 2017 Aug 01
TI  - Naturally Acquired Immunity Against Rotavirus Infection and Gastroenteritis in
      Children: Paired Reanalyses of Birth Cohort Studies.
PG  - 317-326
LID - 10.1093/infdis/jix310 [doi]
AB  - Background: Observational studies in socioeconomically distinct populations have 
      yielded conflicting conclusions about the strength of naturally acquired immunity
      against rotavirus gastroenteritis (RVGE), mirroring vaccine underperformance in
      low-income countries. We revisited birth cohort studies to understand naturally
      acquired protection against rotavirus infection and RVGE. Methods: We reanalyzed 
      data from 200 Mexican and 373 Indian children followed from birth to 2 and 3
      years of age, respectively. We reassessed protection against RVGE, decomposing
      the incidence rate into the rate of rotavirus infection and the risk of RVGE
      given infection, and tested for serum antibody correlates of protection using
      regression models. Results: Risk for primary, secondary, and subsequent
      infections to cause RVGE decreased per log-month of age by 28% (95% confidence
      interval [CI], 12%-41%), 69% (95% CI, 30%-86%), and 64% (95% CI, -186% to 95%),
      respectively, in Mexico City, and by 10% (95% CI, -1% to 19%), 51% (95% CI,
      41%-59%) and 67% (95% CI, 57%-75%), respectively, in Vellore. Elevated serum
      immunoglobulin A and immunoglobulin G titers were associated with partial
      protection against rotavirus infection. Associations between older age and
      reduced risk for RVGE or moderate-to-severe RVGE given infection persisted after 
      controlling for antibody levels. Conclusions: Dissimilar estimates of protection 
      against RVGE may be due in part to age-related, antibody-independent risk for
      rotavirus infections to cause RVGE.
FAU - Lewnard, Joseph A
AU  - Lewnard JA
AD  - Center for Communicable Disease Dynamics, Harvard T.H. Chan School of Public
      Health, Boston, Massachusetts.
AD  - Department of Epidemiology of Microbial Diseases, Yale School of Public Health,
      New Haven, Connecticut.
FAU - Lopman, Benjamin A
AU  - Lopman BA
AD  - Department of Epidemiology, Rollins School of Public Health, Emory University.
AD  - Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, 
      Georgia.
FAU - Parashar, Umesh D
AU  - Parashar UD
AD  - Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, 
      Georgia.
FAU - Bar-Zeev, Naor
AU  - Bar-Zeev N
AD  - Institute of Infection and Global Health, University of Liverpool, United
      Kingdom.
AD  - Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine,
      University of Malawi, Blantyre.
FAU - Samuel, Prasanna
AU  - Samuel P
AD  - Department of Gastrointestinal Sciences, Christian Medical College, Vellore,
      Tamil Nadu, India.
FAU - Guerrero, M Lourdes
AU  - Guerrero ML
AD  - Instituto Nacional de Ciences Medicas y Nutricion Salvador Zubiran, Mexico City, 
      Mexico.
FAU - Ruiz-Palacios, Guillermo M
AU  - Ruiz-Palacios GM
AD  - Instituto Nacional de Ciences Medicas y Nutricion Salvador Zubiran, Mexico City, 
      Mexico.
FAU - Kang, Gagandeep
AU  - Kang G
AD  - Department of Gastrointestinal Sciences, Christian Medical College, Vellore,
      Tamil Nadu, India.
FAU - Pitzer, Virginia E
AU  - Pitzer VE
AD  - Department of Epidemiology of Microbial Diseases, Yale School of Public Health,
      New Haven, Connecticut.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
SB  - AIM
SB  - IM
MH  - *Adaptive Immunity
MH  - Age Distribution
MH  - Antibodies, Viral/blood
MH  - Child, Preschool
MH  - Feces/virology
MH  - Female
MH  - Follow-Up Studies
MH  - Gastroenteritis/epidemiology/*immunology/virology
MH  - Humans
MH  - *Immunity, Innate
MH  - India/epidemiology
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Mexico/epidemiology
MH  - Regression Analysis
MH  - Rotavirus
MH  - Rotavirus Infections/epidemiology/*immunology
OTO - NOTNLM
OT  - birth cohort
OT  - gastroenteritis
OT  - immunity
OT  - natural infection
OT  - rotavirus
EDAT- 2017/09/02 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/09/02 06:00
PHST- 2017/03/24 [received]
PHST- 2017/06/29 [accepted]
AID - 3926056 [pii]
AID - 10.1093/infdis/jix310 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Aug 1;216(3):317-326. doi: 10.1093/infdis/jix310.