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The relationship between microRNAs and the STAT3-related signaling pathway in cancer.

Abstract MicroRNAs are non-coding RNAs that regulate gene expression by targeting messenger RNA molecules in 3' untranslated region. Mounting evidence indicates that microRNAs regulate several factors to influence various biological activities that are related to carcinogenesis, including signal transducer and activator of transcription 3, which is a transcription factor that also acts as an oncogene. MicroRNAs influence signal transducer and activator of transcription 3 either by directly targeting or via other pathway components upstream or downstream of signal transducer and activator of transcription 3 such as Janus kinases, members of the suppressor of cytokine signaling family, and other genes that regulate cell proliferation, apoptosis, migration, invasion, and epithelial-mesenchymal transition. However, signal transducer and activator of transcription 3 activation changes the pattern of expression of microRNAs and mediates tumorigenesis. Moreover, the relationship between signal transducer and activator of transcription 3 and microRNAs varies among different kinds of cancers. A specific microRNA may act as an oncogene or tumor suppressor in different cancers, and microRNAs also directly or indirectly regulate signal transducer and activator of transcription 3 via pathways in the same cancers. In this review, we focus on the reciprocal regulation and roles of microRNAs and signal transducer and activator of transcription 3 in cancer, as well as describe current research progress on this relationship. A better understanding of this relationship may facilitate in the identification of targets for clinical therapeutics.
PMID
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Authors

Mayor MeshTerms
Keywords

Janus kinases

MicroRNAs

cancer

signal transducer and activator of transcription 3 signaling pathway

suppressor of cytokine signaling

Journal Title tumour biology : the journal of the international society for oncodevelopmental biology and medicine
Publication Year Start




PMID- 28859543
OWN - NLM
STAT- MEDLINE
DA  - 20170901
DCOM- 20170912
LR  - 20170912
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 39
IP  - 7
DP  - 2017 Jul
TI  - The relationship between microRNAs and the STAT3-related signaling pathway in
      cancer.
PG  - 1010428317719869
LID - 10.1177/1010428317719869 [doi]
AB  - MicroRNAs are non-coding RNAs that regulate gene expression by targeting
      messenger RNA molecules in 3' untranslated region. Mounting evidence indicates
      that microRNAs regulate several factors to influence various biological
      activities that are related to carcinogenesis, including signal transducer and
      activator of transcription 3, which is a transcription factor that also acts as
      an oncogene. MicroRNAs influence signal transducer and activator of transcription
      3 either by directly targeting or via other pathway components upstream or
      downstream of signal transducer and activator of transcription 3 such as Janus
      kinases, members of the suppressor of cytokine signaling family, and other genes 
      that regulate cell proliferation, apoptosis, migration, invasion, and
      epithelial-mesenchymal transition. However, signal transducer and activator of
      transcription 3 activation changes the pattern of expression of microRNAs and
      mediates tumorigenesis. Moreover, the relationship between signal transducer and 
      activator of transcription 3 and microRNAs varies among different kinds of
      cancers. A specific microRNA may act as an oncogene or tumor suppressor in
      different cancers, and microRNAs also directly or indirectly regulate signal
      transducer and activator of transcription 3 via pathways in the same cancers. In 
      this review, we focus on the reciprocal regulation and roles of microRNAs and
      signal transducer and activator of transcription 3 in cancer, as well as describe
      current research progress on this relationship. A better understanding of this
      relationship may facilitate in the identification of targets for clinical
      therapeutics.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin
      University, Changchun, P.R. China.
FAU - Li, Junyao
AU  - Li J
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin
      University, Changchun, P.R. China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin
      University, Changchun, P.R. China.
FAU - Meng, Guangping
AU  - Meng G
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin
      University, Changchun, P.R. China.
FAU - Lv, Xuejiao
AU  - Lv X
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin
      University, Changchun, P.R. China.
FAU - Zhou, Hong
AU  - Zhou H
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin
      University, Changchun, P.R. China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin
      University, Changchun, P.R. China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital of Jilin
      University, Changchun, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental
      Biology and Medicine
JID - 8409922
RN  - 0 (MicroRNAs)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
SB  - IM
MH  - Apoptosis/genetics
MH  - Carcinogenesis/*genetics
MH  - Cell Proliferation/genetics
MH  - Epithelial-Mesenchymal Transition
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Neoplasms/*genetics/pathology
MH  - STAT3 Transcription Factor/*genetics
MH  - Signal Transduction
OTO - NOTNLM
OT  - Janus kinases
OT  - MicroRNAs
OT  - cancer
OT  - signal transducer and activator of transcription 3 signaling pathway
OT  - suppressor of cytokine signaling
EDAT- 2017/09/02 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/09/02 06:00
AID - 10.1177/1010428317719869 [doi]
PST - ppublish
SO  - Tumour Biol. 2017 Jul;39(7):1010428317719869. doi: 10.1177/1010428317719869.