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Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease.

Abstract Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder that affects organs with melanocytes. The sunset glow fundus (SGF) in VKH disease was evaluated with polarization-sensitive optical coherence tomography (PS-OCT).
PMID
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Authors

Mayor MeshTerms

Diagnostic Techniques, Ophthalmological

Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28863408
OWN - NLM
STAT- MEDLINE
DA  - 20170901
DCOM- 20170908
LR  - 20170908
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 11
DP  - 2017 Sep 01
TI  - Polarization-Sensitive Optical Coherence Tomographic Documentation of Choroidal
      Melanin Loss in Chronic Vogt-Koyanagi-Harada Disease.
PG  - 4467-4476
LID - 10.1167/iovs.17-22117 [doi]
AB  - Purpose: Vogt-Koyanagi-Harada (VKH) disease is a systemic autoimmune disorder
      that affects organs with melanocytes. The sunset glow fundus (SGF) in VKH disease
      was evaluated with polarization-sensitive optical coherence tomography (PS-OCT). 
      Methods: The study involved 28 eyes from 14 patients with chronic VKH disease, 21
      eyes from 21 age-matched controls, and 22 eyes from 22 high-myopic patients with 
      a tessellated fundus. VKH eyes were grouped into sunset or non-sunset groups on
      the basis of color fundus images. The presence of melanin in the choroid was
      determined by using the degree of polarization uniformity (DOPU) obtained by
      PS-OCT. The sunset glow index (SGI) was calculated by using color fundus images. 
      Presence of an SGF was evaluated by using DOPU, SGI, subfoveal choroidal
      thicknesses, near-infrared images, and autofluorescence images at 488 nm (SW-AF) 
      and 785 nm (NIR-AF). Results: There were 16 eyes in the sunset group and 12 eyes 
      in the non-sunset group. For all eyes in the sunset group, the disappearance of
      choroidal melanin was clearly detected with PS-OCT. Percentage areas of low DOPU 
      in the choroidal interstitial stroma of the sunset group were significantly lower
      than those of other groups and showed no overlap with other groups. The
      distribution of choroidal thicknesses and SGI in the sunset group substantially
      overlapped with other groups. The subjective analyses of the sunset and
      non-sunset groups, using near infrared, SW-AF, or NIR-AF, showed substantial
      inconsistencies with the PS-OCT results. Conclusions: PS-OCT provides an in vivo 
      objective evaluation of choroidal melanin loss of the SGF in chronic VKH disease.
FAU - Miura, Masahiro
AU  - Miura M
AD  - Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center,
      Ami, Japan.
AD  - Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
FAU - Makita, Shuichi
AU  - Makita S
AD  - Computational Optics Group, University of Tsukuba, Tsukuba, Japan.
FAU - Yasuno, Yoshiaki
AU  - Yasuno Y
AD  - Computational Optics Group, University of Tsukuba, Tsukuba, Japan.
FAU - Tsukahara, Rintaro
AU  - Tsukahara R
AD  - Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center,
      Ami, Japan.
AD  - Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
FAU - Usui, Yoshihiko
AU  - Usui Y
AD  - Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
FAU - Rao, Narsing A
AU  - Rao NA
AD  - USC-Roski Eye Institute, University of Southern California, Los Angeles,
      California, United States.
FAU - Ikuno, Yasushi
AU  - Ikuno Y
AD  - Ikuno Eye Center, Osaka, Japan.
FAU - Uematsu, Sato
AU  - Uematsu S
AD  - Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita,
      Japan.
FAU - Agawa, Tetsuya
AU  - Agawa T
AD  - Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
FAU - Iwasaki, Takuya
AU  - Iwasaki T
AD  - Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical Center,
      Ami, Japan.
AD  - Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
FAU - Goto, Hiroshi
AU  - Goto H
AD  - Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Biomarkers)
RN  - 0 (Melanins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/metabolism
MH  - Choroid Diseases/*metabolism
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - Melanins/*metabolism
MH  - Melanocytes/metabolism
MH  - Microscopy, Polarization
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Tomography, Optical Coherence
MH  - Uveomeningoencephalitic Syndrome/diagnosis/*metabolism
EDAT- 2017/09/02 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/09/02 06:00
AID - 2653226 [pii]
AID - 10.1167/iovs.17-22117 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4467-4476. doi:
      10.1167/iovs.17-22117.