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Characterization of Dengue Virus Infections Among Febrile Children Clinically Diagnosed With a Non-Dengue Illness, Managua, Nicaragua.

Abstract We sought to characterize dengue virus (DENV) infections among febrile children enrolled in a pediatric cohort study who were clinically diagnosed with a non-dengue illness ("C cases").
PMID
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Authors

Mayor MeshTerms
Keywords

Dengue virus

humoral immunity

rRT-PCR

viral load

Journal Title the journal of infectious diseases
Publication Year Start




PMID- 28863466
OWN - NLM
STAT- MEDLINE
DA  - 20170902
DCOM- 20170907
LR  - 20170907
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 215
IP  - 12
DP  - 2017 Jun 15
TI  - Characterization of Dengue Virus Infections Among Febrile Children Clinically
      Diagnosed With a Non-Dengue Illness, Managua, Nicaragua.
PG  - 1816-1823
LID - 10.1093/infdis/jix195 [doi]
AB  - Background: We sought to characterize dengue virus (DENV) infections among
      febrile children enrolled in a pediatric cohort study who were clinically
      diagnosed with a non-dengue illness ("C cases"). Methods: DENV infections were
      detected and viral load quantitated by real-time reverse transcription-polymerase
      chain reaction in C cases presenting between January 2007 and January 2013.
      Results: One hundred forty-one of 2892 C cases (4.88%) tested positive for DENV. 
      Of all febrile cases in the study, DENV-positive C cases accounted for an
      estimated 52.0% of patients with DENV viremia at presentation. Compared with
      previously detected, symptomatic dengue cases, DENV-positive C cases were
      significantly less likely to develop long-lasting humoral immune responses to
      DENV, as measured in healthy annual serum samples (79.7% vs 47.8%; P < .001).
      Humoral immunity was associated with viral load at presentation: 40 of 43
      patients (93.0%) with a viral load >/=7.0 log10 copies/mL serum developed the
      expected rise in anti-DENV antibodies in annual samples versus 13 of 68 (19.1%)
      patients with a viral load below this level (P < .001). Conclusions: Antibody
      responses to DENV-positive C cases differ from responses to classic symptomatic
      dengue. These findings have important implications for DENV transmission
      modeling, immunology, and epidemiologic surveillance.
FAU - Waggoner, Jesse J
AU  - Waggoner JJ
AD  - Department of Medicine, Division of Infectious Diseases and Geographic Medicine.
FAU - Gresh, Lionel
AU  - Gresh L
AD  - Sustainable Sciences Institute.
FAU - Mohamed-Hadley, Alisha
AU  - Mohamed-Hadley A
AD  - Department of Pathology, Stanford University School of Medicine, Stanford,
      California.
FAU - Balmaseda, Angel
AU  - Balmaseda A
AD  - National Virology Laboratory, Centro Nacional de Diagnostico y Referencia,
      Ministry of Health.
FAU - Soda, K James
AU  - Soda KJ
AD  - Department of Scientific Computing, Florida State University, Tallahassee.
FAU - Abeynayake, Janaki
AU  - Abeynayake J
AD  - Department of Pathology, Stanford University School of Medicine, Stanford,
      California.
FAU - Sahoo, Malaya K
AU  - Sahoo MK
AD  - Department of Pathology, Stanford University School of Medicine, Stanford,
      California.
FAU - Liu, Yuanyuan
AU  - Liu Y
AD  - Department of Pathology, Stanford University School of Medicine, Stanford,
      California.
FAU - Kuan, Guillermina
AU  - Kuan G
AD  - Centro de Salud Socrates Flores Vivas, Ministry of Health, Managua, Nicaragua.
FAU - Harris, Eva
AU  - Harris E
AD  - Division of Infectious Diseases and Vaccinology, School of Public Health,
      University of California, Berkeley.
FAU - Pinsky, Benjamin A
AU  - Pinsky BA
AD  - Department of Medicine, Division of Infectious Diseases and Geographic Medicine.
AD  - Department of Pathology, Stanford University School of Medicine, Stanford,
      California.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Viral)
RN  - 0 (RNA, Viral)
SB  - AIM
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Antibody Formation/*immunology
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Dengue/*diagnosis/epidemiology/virology
MH  - Dengue Virus/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fever/etiology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Nicaragua/epidemiology
MH  - RNA, Viral/blood
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Viremia/genetics
OTO - NOTNLM
OT  - Dengue virus
OT  - humoral immunity
OT  - rRT-PCR
OT  - viral load
EDAT- 2017/09/03 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/09/03 06:00
PHST- 2017/02/23 [received]
PHST- 2017/04/21 [accepted]
AID - 3747427 [pii]
AID - 10.1093/infdis/jix195 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Jun 15;215(12):1816-1823. doi: 10.1093/infdis/jix195.