PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1.

Abstract Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues. Specific interactions have been described between PfEMP1 and human endothelial proteins CD36, intercellular adhesion molecule-1 (ICAM-1), and endothelial protein C receptor (EPCR); however, cytoadhesion patterns typical for pediatric malaria syndromes and the associated PfEMP1 members are still undefined.
PMID
Related Publications

Severe malaria is associated with parasite binding to endothelial protein C receptor.

The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1.

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria.

Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding.

Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum-Infected Erythrocytes to Endothelial Cells.

Authors

Mayor MeshTerms
Keywords

EPCR

ICAM-1

PfEMP1

Plasmodium falciparum

cerebral malaria

Journal Title the journal of infectious diseases
Publication Year Start




PMID- 28863469
OWN - NLM
STAT- MEDLINE
DA  - 20170902
DCOM- 20170907
LR  - 20170907
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 215
IP  - 12
DP  - 2017 Jun 15
TI  - Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors
      and Express EPCR and ICAM-1-Binding PfEMP1.
PG  - 1918-1925
LID - 10.1093/infdis/jix230 [doi]
AB  - Background: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
      mediates the binding and accumulation of infected erythrocytes (IE) to blood
      vessels and tissues. Specific interactions have been described between PfEMP1 and
      human endothelial proteins CD36, intercellular adhesion molecule-1 (ICAM-1), and 
      endothelial protein C receptor (EPCR); however, cytoadhesion patterns typical for
      pediatric malaria syndromes and the associated PfEMP1 members are still
      undefined. Methods: In a cohort of 94 hospitalized children with malaria, we
      characterized the binding properties of IE collected on admission, and var gene
      transcription using quantitative polymerase chain reaction. Results: IE from
      patients with cerebral malaria were more likely to bind EPCR and ICAM-1 than IE
      from children with uncomplicated malaria (P = .007). The level of transcripts
      encoding CIDRalpha1.4 and CIDRalpha1.5 domain subclasses was higher in patients
      with severe disease (P < .05). IE populations exhibiting binding to all 3
      receptors had higher levels of transcripts encoding PfEMP1 with CIDRalpha1.4 and 
      Duffy binding-like (DBL)-beta3 domains than parasites, which only bound CD36.
      Conclusions: These results underpin the significance of EPCR binding in pediatric
      malaria patients that require hospital admission, and support the notion that
      complementary receptor interactions of EPCR binding PfEMP1with ICAM-1 amplifies
      development of severe malaria symptoms.
FAU - Tuikue Ndam, Nicaise
AU  - Tuikue Ndam N
AD  - UMR 216, Mere et enfant face aux infections tropicales, Institut de Recherche
      pour le developpement, COMUE Sorbonne Paris Cite, Faculte de pharmacie,
      Laboratoire d'Excellence GR-Ex, DHU Risques et Grossesse, France.
FAU - Moussiliou, Azizath
AU  - Moussiliou A
AD  - UMR 216, Mere et enfant face aux infections tropicales, Institut de Recherche
      pour le developpement, COMUE Sorbonne Paris Cite, Faculte de pharmacie,
      Laboratoire d'Excellence GR-Ex, DHU Risques et Grossesse, France.
FAU - Lavstsen, Thomas
AU  - Lavstsen T
AD  - Centre for Medical Parasitology, Department of Immunology and Microbiology,
      Faculty of Health and Medical Sciences, University of Copenhagen and Department
      of Infectious Diseases, Copenhagen University Hospital, Denmark.
FAU - Kamaliddin, Claire
AU  - Kamaliddin C
AD  - UMR 216, Mere et enfant face aux infections tropicales, Institut de Recherche
      pour le developpement, COMUE Sorbonne Paris Cite, Faculte de pharmacie,
      Laboratoire d'Excellence GR-Ex, DHU Risques et Grossesse, France.
FAU - Jensen, Anja T R
AU  - Jensen ATR
AD  - Centre for Medical Parasitology, Department of Immunology and Microbiology,
      Faculty of Health and Medical Sciences, University of Copenhagen and Department
      of Infectious Diseases, Copenhagen University Hospital, Denmark.
FAU - Mama, Atikatou
AU  - Mama A
AD  - Centre d'Etude et de Recherche sur le paludisme associe a la Grossesse et a
      l'Enfance, Universite d'Abomey-Calavi.
FAU - Tahar, Rachida
AU  - Tahar R
AD  - UMR 216, Mere et enfant face aux infections tropicales, Institut de Recherche
      pour le developpement, COMUE Sorbonne Paris Cite, Faculte de pharmacie,
      Laboratoire d'Excellence GR-Ex, DHU Risques et Grossesse, France.
FAU - Wang, Christian W
AU  - Wang CW
AD  - Centre for Medical Parasitology, Department of Immunology and Microbiology,
      Faculty of Health and Medical Sciences, University of Copenhagen and Department
      of Infectious Diseases, Copenhagen University Hospital, Denmark.
FAU - Jespersen, Jakob S
AU  - Jespersen JS
AD  - Centre for Medical Parasitology, Department of Immunology and Microbiology,
      Faculty of Health and Medical Sciences, University of Copenhagen and Department
      of Infectious Diseases, Copenhagen University Hospital, Denmark.
FAU - Alao, Jules M
AU  - Alao JM
AD  - Departement de pediatrie, Hopital Mere-enfant de la lagune, Cotonou, Benin.
FAU - Gamain, Benoit
AU  - Gamain B
AD  - Universite Sorbonne Paris Cite, Universite Paris Diderot, Inserm, INTS, Unite
      Biologie Integree du Globule Rouge, Laboratoire d'Excellence GR-Ex, France.
FAU - Theander, Thor G
AU  - Theander TG
AD  - Centre for Medical Parasitology, Department of Immunology and Microbiology,
      Faculty of Health and Medical Sciences, University of Copenhagen and Department
      of Infectious Diseases, Copenhagen University Hospital, Denmark.
FAU - Deloron, Philippe
AU  - Deloron P
AD  - UMR 216, Mere et enfant face aux infections tropicales, Institut de Recherche
      pour le developpement, COMUE Sorbonne Paris Cite, Faculte de pharmacie,
      Laboratoire d'Excellence GR-Ex, DHU Risques et Grossesse, France.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antigens, CD)
RN  - 0 (PROCR protein, human)
RN  - 0 (Protozoan Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (erythrocyte membrane protein 1, Plasmodium falciparum)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - AIM
SB  - IM
MH  - Antigens, CD/*metabolism
MH  - Cell Adhesion
MH  - Child, Preschool
MH  - Endothelial Cells/metabolism
MH  - Humans
MH  - Infant
MH  - Intercellular Adhesion Molecule-1/*metabolism
MH  - Malaria, Cerebral/*parasitology
MH  - Malaria, Falciparum/*parasitology
MH  - Plasmodium falciparum/*metabolism
MH  - Protein Binding
MH  - Protozoan Proteins/*metabolism
MH  - Receptors, Cell Surface/*metabolism
MH  - Transcription, Genetic
OTO - NOTNLM
OT  - EPCR
OT  - ICAM-1
OT  - PfEMP1
OT  - Plasmodium falciparum
OT  - cerebral malaria
EDAT- 2017/09/03 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/09/03 06:00
PHST- 2017/04/04 [received]
PHST- 2017/05/10 [accepted]
AID - 3869437 [pii]
AID - 10.1093/infdis/jix230 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Jun 15;215(12):1918-1925. doi: 10.1093/infdis/jix230.