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A Case of Human Lassa Virus Infection With Robust Acute T-Cell Activation and Long-Term Virus-Specific T-Cell Responses.

Abstract A nurse who acquired Lassa virus infection in Togo in the spring of 2016 was repatriated to the United States for care at Emory University Hospital. Serial sampling from this patient permitted the characterization of several aspects of the innate and cellular immune responses to Lassa virus. Although most of the immune responses correlated with the kinetics of viremia resolution, the CD8 T-cell response was of surprisingly high magnitude and prolonged duration, implying prolonged presentation of viral antigens. Indeed, long after viremia resolution, there was persistent viral RNA detected in the semen of the patient, accompanied by epididymitis, suggesting the male reproductive tract as 1 site of antigen persistence. Consistent with the magnitude of acute T-cell responses, the patient ultimately developed long-term, polyfunctional memory T-cell responses to Lassa virus.
PMID
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Authors

Mayor MeshTerms

Immunity, Cellular

Keywords

Lassa virus

T cells

biomarkers

human

immunology

Journal Title the journal of infectious diseases
Publication Year Start




PMID- 28863472
OWN - NLM
STAT- MEDLINE
DA  - 20170902
DCOM- 20170907
LR  - 20170907
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 215
IP  - 12
DP  - 2017 Jun 15
TI  - A Case of Human Lassa Virus Infection With Robust Acute T-Cell Activation and
      Long-Term Virus-Specific T-Cell Responses.
PG  - 1862-1872
LID - 10.1093/infdis/jix201 [doi]
AB  - A nurse who acquired Lassa virus infection in Togo in the spring of 2016 was
      repatriated to the United States for care at Emory University Hospital. Serial
      sampling from this patient permitted the characterization of several aspects of
      the innate and cellular immune responses to Lassa virus. Although most of the
      immune responses correlated with the kinetics of viremia resolution, the CD8
      T-cell response was of surprisingly high magnitude and prolonged duration,
      implying prolonged presentation of viral antigens. Indeed, long after viremia
      resolution, there was persistent viral RNA detected in the semen of the patient, 
      accompanied by epididymitis, suggesting the male reproductive tract as 1 site of 
      antigen persistence. Consistent with the magnitude of acute T-cell responses, the
      patient ultimately developed long-term, polyfunctional memory T-cell responses to
      Lassa virus.
CI  - Published by Oxford University Press for the Infectious Diseases Society of
      America 2017. This work is written by (a) US Government employee(s) and is in the
      public domain in the US.
FAU - McElroy, Anita K
AU  - McElroy AK
AD  - Departments of Pediatrics.
AD  - CDC Viral Special Pathogens Branch, Atlanta, Georgia.
FAU - Akondy, Rama S
AU  - Akondy RS
AD  - Microbiology and Immunology.
FAU - Harmon, Jessica R
AU  - Harmon JR
AD  - CDC Viral Special Pathogens Branch, Atlanta, Georgia.
FAU - Ellebedy, Ali H
AU  - Ellebedy AH
AD  - Microbiology and Immunology.
FAU - Cannon, Deborah
AU  - Cannon D
AD  - CDC Viral Special Pathogens Branch, Atlanta, Georgia.
FAU - Klena, John D
AU  - Klena JD
AD  - CDC Viral Special Pathogens Branch, Atlanta, Georgia.
FAU - Sidney, John
AU  - Sidney J
AD  - La Jolla Institute for Allergy and Immunology Center for Infectious Disease,
      California.
FAU - Sette, Alessandro
AU  - Sette A
AD  - La Jolla Institute for Allergy and Immunology Center for Infectious Disease,
      California.
FAU - Mehta, Aneesh K
AU  - Mehta AK
AD  - Medicine, Division of Infectious Disease.
FAU - Kraft, Colleen S
AU  - Kraft CS
AD  - Medicine, Division of Infectious Disease.
AD  - Pathology and Laboratory Medicine, Emory University.
FAU - Lyon, Marshall G
AU  - Lyon MG
AD  - Medicine, Division of Infectious Disease.
FAU - Varkey, Jay B
AU  - Varkey JB
AD  - Medicine, Division of Infectious Disease.
FAU - Ribner, Bruce S
AU  - Ribner BS
AD  - Medicine, Division of Infectious Disease.
FAU - Nichol, Stuart T
AU  - Nichol ST
AD  - CDC Viral Special Pathogens Branch, Atlanta, Georgia.
FAU - Spiropoulou, Christina F
AU  - Spiropoulou CF
AD  - CDC Viral Special Pathogens Branch, Atlanta, Georgia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Amides)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Antigens, Viral)
RN  - 0 (Antiviral Agents)
RN  - 0 (Pyrazines)
RN  - 49717AWG6K (Ribavirin)
RN  - EW5GL2X7E0 (favipiravir)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Amides/therapeutic use
MH  - Antibodies, Viral/*blood
MH  - Antigens, Viral/immunology
MH  - Antiviral Agents/therapeutic use
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - *Immunity, Cellular
MH  - Immunoglobulin Class Switching/genetics
MH  - Lassa Fever/blood/*immunology
MH  - Lassa virus/*immunology/*isolation & purification
MH  - Lymphocyte Activation
MH  - Male
MH  - Pyrazines/therapeutic use
MH  - Ribavirin/therapeutic use
MH  - Viremia/blood
OTO - NOTNLM
OT  - Lassa virus
OT  - T cells
OT  - biomarkers
OT  - human
OT  - immunology
EDAT- 2017/09/03 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/09/03 06:00
PHST- 2017/01/11 [received]
PHST- 2017/04/24 [accepted]
AID - 3871090 [pii]
AID - 10.1093/infdis/jix201 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Jun 15;215(12):1862-1872. doi: 10.1093/infdis/jix201.