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Thromboprophylaxis Failure in the Adult Medical Inpatient.

Abstract Venous thromboembolism (VTE), a leading cause of morbidity and mortality among hospitalized patients, is often due to prophylaxis failure rather than omission, but few studies have identified the risk factors for failure. Risk factors for thromboprophylaxis failure include personal or family history of VTE, use of vasopressors or inotropes, increased body mass index, cranial surgery, intensive care patient, leukocytosis, indwelling central venous catheter and admission from a long-term care facility. Identifying patients at risk for thromboprophylaxis failure should prompt close observation during hospitalization for signs of VTE, close observation after discharge and potentially more aggressive prophylaxis strategies, although no specific guidelines exist for medical patients at this time.
PMID
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Authors

Mayor MeshTerms
Keywords

Hospital medicine

Patient safety

Prophylaxis

Pulmonary embolism

Thromboembolism

Journal Title the american journal of the medical sciences
Publication Year Start




PMID- 28864367
OWN - NLM
STAT- MEDLINE
DA  - 20170902
DCOM- 20170908
LR  - 20170908
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 354
IP  - 2
DP  - 2017 Aug
TI  - Thromboprophylaxis Failure in the Adult Medical Inpatient.
PG  - 107-116
LID - S0002-9629(17)30136-2 [pii]
LID - 10.1016/j.amjms.2017.03.011 [doi]
AB  - Venous thromboembolism (VTE), a leading cause of morbidity and mortality among
      hospitalized patients, is often due to prophylaxis failure rather than omission, 
      but few studies have identified the risk factors for failure. Risk factors for
      thromboprophylaxis failure include personal or family history of VTE, use of
      vasopressors or inotropes, increased body mass index, cranial surgery, intensive 
      care patient, leukocytosis, indwelling central venous catheter and admission from
      a long-term care facility. Identifying patients at risk for thromboprophylaxis
      failure should prompt close observation during hospitalization for signs of VTE, 
      close observation after discharge and potentially more aggressive prophylaxis
      strategies, although no specific guidelines exist for medical patients at this
      time.
CI  - Copyright (c) 2017 Southern Society for Clinical Investigation. Published by
      Elsevier Inc. All rights reserved.
FAU - Northup, Amanda
AU  - Northup A
AD  - Division of Cardiology, Medical University of South Carolina, Charleston, South
      Carolina. Electronic address: [email protected]
FAU - Wilcox, Susan
AU  - Wilcox S
AD  - Department of Medicine, Medical University of South Carolina, Charleston, South
      Carolina; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine,
      Medical University of South Carolina, Charleston, South Carolina; Division of
      Emergency Medicine, Medical University of South Carolina, Charleston, South
      Carolina.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170306
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
SB  - AIM
SB  - IM
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Risk Factors
MH  - Venous Thromboembolism/*etiology/genetics
OTO - NOTNLM
OT  - Hospital medicine
OT  - Patient safety
OT  - Prophylaxis
OT  - Pulmonary embolism
OT  - Thromboembolism
EDAT- 2017/09/03 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/09/03 06:00
PHST- 2016/11/15 [received]
PHST- 2017/03/01 [revised]
PHST- 2017/03/03 [accepted]
AID - S0002-9629(17)30136-2 [pii]
AID - 10.1016/j.amjms.2017.03.011 [doi]
PST - ppublish
SO  - Am J Med Sci. 2017 Aug;354(2):107-116. doi: 10.1016/j.amjms.2017.03.011. Epub
      2017 Mar 6.