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Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Cardiovascular Events in Diabetics With Coronary Artery Disease.

Abstract It has been demonstrated that an elevated ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) is a risk factor of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM) and is also found to be associated with cardiovascular events (CVEs) in the general population. However, its prognostic value in patients with T2DM along with CAD remains to be determined.
PMID
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Authors

Mayor MeshTerms
Keywords

Coronary artery disease

High-density lipoprotein cholesterol

Ratio

Triglyceride

Type 2 diabetes

Journal Title the american journal of the medical sciences
Publication Year Start




PMID- 28864368
OWN - NLM
STAT- In-Process
DA  - 20170902
LR  - 20170902
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 354
IP  - 2
DP  - 2017 Aug
TI  - Triglyceride to High-Density Lipoprotein Cholesterol Ratio and Cardiovascular
      Events in Diabetics With Coronary Artery Disease.
PG  - 117-124
LID - S0002-9629(17)30199-4 [pii]
LID - 10.1016/j.amjms.2017.03.032 [doi]
AB  - BACKGROUND: It has been demonstrated that an elevated ratio of triglycerides (TG)
      to high-density lipoprotein cholesterol (HDL-C) is a risk factor of coronary
      artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM) and is also
      found to be associated with cardiovascular events (CVEs) in the general
      population. However, its prognostic value in patients with T2DM along with CAD
      remains to be determined. MATERIALS AND METHODS: A total of 1,447 consecutive
      patients with T2DM with angiographic-proven stable CAD were enrolled in the
      present study and followed-up for an average of 20.3 months. The characteristics 
      of all patients including fasting lipid profile were obtained at baseline and
      multivariate Cox proportional hazards models were constructed using log TG/HDL-C 
      as a predictor variable. The relationships between CVEs and total cholesterol
      (TC), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, TC/HDL-C,
      LDL-C/HDL-C and apolipoprotein B/ apolipoprotein AI (apoB/apoAI) were also
      explored. RESULTS: Compared with patients without CVEs, the ones who experienced 
      CVEs had a higher TG/HDL-C ratio. Univariable regression revealed a significant
      association of log TG/HDL-C with CVEs (hazard ratio = 2.5, P = 0.015). After
      adjusting for multiple traditional risk factors of cardiovascular disease, the
      association was still found (hazard ratio = 2.47, P = 0.047). Moreover, results
      suggested that the ratios of non-HDL-C, TC/HDL-C, LDL-C/HDL-C and apoB/apoAI were
      not predictors for CVEs in T2DM. CONCLUSIONS: In our primary study, data
      suggested that elevated TG/HDL-C value might be a useful predictor for future
      CVEs in Chinese patients with T2DM with stable CAD. Further study is needed to
      confirm our findings.
CI  - Copyright (c) 2017 Southern Society for Clinical Investigation. Published by
      Elsevier Inc. All rights reserved.
FAU - Yang, Sheng-Hua
AU  - Yang SH
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Du, Ying
AU  - Du Y
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Li, Xiao-Lin
AU  - Li XL
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Li, Sha
AU  - Li S
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Xu, Rui-Xia
AU  - Xu RX
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Zhu, Cheng-Gang
AU  - Zhu CG
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Guo, Yuan-Lin
AU  - Guo YL
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Wu, Na-Qiong
AU  - Wu NQ
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Qing, Ping
AU  - Qing P
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Gao, Ying
AU  - Gao Y
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Cui, Chuan-Jue
AU  - Cui CJ
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Dong, Qian
AU  - Dong Q
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Sun, Jing
AU  - Sun J
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China.
FAU - Li, Jian-Jun
AU  - Li JJ
AD  - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, FuWai
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical
      Sciences, Peking Union Medical College, Beijing, China. Electronic address:
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170406
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
OTO - NOTNLM
OT  - Coronary artery disease
OT  - High-density lipoprotein cholesterol
OT  - Ratio
OT  - Triglyceride
OT  - Type 2 diabetes
EDAT- 2017/09/03 06:00
MHDA- 2017/09/03 06:00
CRDT- 2017/09/03 06:00
PHST- 2016/11/09 [received]
PHST- 2017/03/07 [revised]
PHST- 2017/03/20 [accepted]
AID - S0002-9629(17)30199-4 [pii]
AID - 10.1016/j.amjms.2017.03.032 [doi]
PST - ppublish
SO  - Am J Med Sci. 2017 Aug;354(2):117-124. doi: 10.1016/j.amjms.2017.03.032. Epub
      2017 Apr 6.