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Pro-Brain Natriuretic Peptide and Troponin T-Hypersensitivity Levels Correlate With the Severity of Liver Dysfunction in Liver Cirrhosis.

Abstract Increased pro-brain natriuretic peptide (pro-BNP) or troponin T-hypersensitivity (TnT-HSST) levels are common in liver cirrhosis. We conducted a retrospective observational study aimed to evaluate the correlation of pro-BNP and TnT-HSST levels with the clinical characteristics, laboratory data and in-hospital outcomes of patients with liver cirrhosis.
PMID
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Authors

Mayor MeshTerms
Keywords

Cirrhotic cardiomyopathy

Liver cirrhosis

Pro-BNP

Prognosis

TnT-HSST

Journal Title the american journal of the medical sciences
Publication Year Start




PMID- 28864370
OWN - NLM
STAT- MEDLINE
DA  - 20170902
DCOM- 20170908
LR  - 20170908
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 354
IP  - 2
DP  - 2017 Aug
TI  - Pro-Brain Natriuretic Peptide and Troponin T-Hypersensitivity Levels Correlate
      With the Severity of Liver Dysfunction in Liver Cirrhosis.
PG  - 131-139
LID - S0002-9629(17)30208-2 [pii]
LID - 10.1016/j.amjms.2017.04.005 [doi]
AB  - BACKGROUND: Increased pro-brain natriuretic peptide (pro-BNP) or troponin
      T-hypersensitivity (TnT-HSST) levels are common in liver cirrhosis. We conducted 
      a retrospective observational study aimed to evaluate the correlation of pro-BNP 
      and TnT-HSST levels with the clinical characteristics, laboratory data and
      in-hospital outcomes of patients with liver cirrhosis. MATERIALS AND METHODS: We 
      selected cirrhotic patients admitted to our hospital between January 2011 and
      June 2014. All eligible patients had pro-BNP or TnT-HSST data, or both. The
      pro-BNP and TnT-HSST data were further divided according to the presence of
      cardiac diseases. RESULTS: The prevalence of pro-BNP level >900pg/mL was 41.72%
      (63 of 151 patients). The prevalence of TnT-HSST level >0.05ng/mL was 11.22% (45 
      of 401 patients). In the overall analysis, pro-BNP level significantly correlated
      with red blood cell (RBC), platelet, ascites, blood urea nitrogen (BUN),
      creatinine (Cr), Child-Pugh score, model for end-stage liver disease (MELD) score
      and in-hospital death; TnT-HSST level significantly correlated with white blood
      cell, ascites, albumin (ALB), BUN, Cr, Child-Pugh score, MELD score and
      in-hospital death. In patients with cardiac diseases, pro-BNP level significantly
      correlated with RBC, ascites, BUN, Cr, Child-Pugh score and MELD score; TnT-HSST 
      level significantly correlated with sex, ascites, white blood cell, ALB, BUN, Cr,
      Child-Pugh score, MELD score and in-hospital death. In patients without cardiac
      diseases, pro-BNP level significantly correlated with ascites, RBC, platelet,
      BUN, Cr, MELD score and in-hospital death; TnT-HSST level significantly
      correlated with age, ascites, RBC, ALB, BUN, Cr, Child-Pugh score, MELD score and
      in-hospital death. CONCLUSIONS: Pro-BNP and TnT-HSST levels significantly
      correlated with the severity of liver dysfunction and in-hospital mortality in
      cirrhosis.
CI  - Copyright (c) 2017 Southern Society for Clinical Investigation. Published by
      Elsevier Inc. All rights reserved.
FAU - Zhao, Jiancheng
AU  - Zhao J
AD  - Department of Gastroenterology (JZ, LR, XG, XQ), General Hospital of Shenyang
      Military Area, Shenyang, China; Department of Rehabilitation (JZ), Jia He
      Hospital of the Liaoning University of Traditional Chinese Medicine, Shenyang,
      China.
FAU - Li, Sai
AU  - Li S
AD  - Department of Cardiology (SL), No. 4 People's Hospital of Shenyang City,
      Shenyang, China.
FAU - Ren, Linan
AU  - Ren L
AD  - Department of Rehabilitation (JZ), Jia He Hospital of the Liaoning University of 
      Traditional Chinese Medicine, Shenyang, China.
FAU - Guo, Xiaozhong
AU  - Guo X
AD  - Department of Rehabilitation (JZ), Jia He Hospital of the Liaoning University of 
      Traditional Chinese Medicine, Shenyang, China. Electronic address:
      [email protected]
FAU - Qi, Xingshun
AU  - Qi X
AD  - Department of Rehabilitation (JZ), Jia He Hospital of the Liaoning University of 
      Traditional Chinese Medicine, Shenyang, China. Electronic address:
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170407
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Troponin T)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - China
MH  - Female
MH  - Humans
MH  - Hypersensitivity
MH  - Liver Cirrhosis/*blood/*complications/diagnosis/pathology
MH  - Liver Diseases/*blood/diagnosis/*etiology
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Prevalence
MH  - Retrospective Studies
MH  - Troponin T/*blood
OTO - NOTNLM
OT  - Cirrhotic cardiomyopathy
OT  - Liver cirrhosis
OT  - Pro-BNP
OT  - Prognosis
OT  - TnT-HSST
EDAT- 2017/09/03 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/09/03 06:00
PHST- 2017/02/27 [received]
PHST- 2017/03/20 [revised]
PHST- 2017/04/05 [accepted]
AID - S0002-9629(17)30208-2 [pii]
AID - 10.1016/j.amjms.2017.04.005 [doi]
PST - ppublish
SO  - Am J Med Sci. 2017 Aug;354(2):131-139. doi: 10.1016/j.amjms.2017.04.005. Epub
      2017 Apr 7.