PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28864375
OWN - NLM
STAT- MEDLINE
DA  - 20170902
DCOM- 20170908
LR  - 20170908
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 354
IP  - 2
DP  - 2017 Aug
TI  - Metformin Use and Vitamin B12 Deficiency: Untangling the Association.
PG  - 165-171
LID - S0002-9629(17)30220-3 [pii]
LID - 10.1016/j.amjms.2017.04.010 [doi]
AB  - BACKGROUND: Current evidence linking vitamin B12 deficiency with metformin use is
      inconsistent. Hence, there is uncertainty regarding the diagnostic approach in
      this scenario. Furthermore, this possible association has not been studied in the
      complete spectrum of patients with diabetes. MATERIALS AND METHODS: We conducted 
      a cross-sectional, controlled study with the objective of assessing differences
      in serum vitamin B12 levels among patients with and without diabetes with
      different metformin-treatment regimens. A total of 150 participants were
      recruited: patients with diabetes (group 1: metformin alone >/=850mg/day, group
      2: patients with type 2 diabetes naive to treatment and group 3: metformin
      >/=850mg/day, in addition to any other oral glucose lowering agent or insulin, or
      both) and without diabetes (group 4: polycystic ovary syndrome or group 5:
      healthy individuals). Serum vitamin B12, folate levels and complete blood counts 
      were obtained for the entire population. Methylmalonic acid and homocysteine were
      obtained for patients when vitamin B12 levels were found to be borderline or low.
      RESULTS: When patients with or without diabetes were compared, no significant
      difference was found in relation to their vitamin B12 levels (517.62 versus
      433.83; P = 0.072). No difference in vitamin B12 levels was found among
      participants with metformin use and metformin naive participants (503.4 versus
      462.3; P = 0.380). CONCLUSIONS: Irrespective of metformin use, no significant
      difference in the serum levels of vitamin B12 was observed, both in patients with
      and without diabetes. In the light of the body of evidence and the results of
      this study, a universal recommendation for vitamin B12 deficiency screening
      cannot be made.
CI  - Copyright (c) 2017 Southern Society for Clinical Investigation. Published by
      Elsevier Inc. All rights reserved.
FAU - Rodriguez-Gutierrez, Rene
AU  - Rodriguez-Gutierrez R
AD  - Knowledge and Evaluation Research Unit in Endocrinology, Department of Medicine, 
      Mayo Clinic, Rochester, Minnesota; Department of Medicine, Mayo Clinic,
      Rochester, Minnesota.
FAU - Montes-Villarreal, Juan
AU  - Montes-Villarreal J
AD  - Division of Endocrinology, Internal Medicine Department, University Hospital "Dr.
      Jose E. Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon,
      Mexico.
FAU - Rodriguez-Velver, Karla Victoria
AU  - Rodriguez-Velver KV
AD  - Division of Endocrinology, Internal Medicine Department, University Hospital "Dr.
      Jose E. Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon,
      Mexico.
FAU - Gonzalez-Velazquez, Camilo
AU  - Gonzalez-Velazquez C
AD  - Internal Medicine Department, University Hospital "Dr. Jose E. Gonzalez",
      Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico.
FAU - Salcido-Montenegro, Alejandro
AU  - Salcido-Montenegro A
AD  - Division of Endocrinology, Internal Medicine Department, University Hospital "Dr.
      Jose E. Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon,
      Mexico.
FAU - Elizondo-Plazas, Anasofia
AU  - Elizondo-Plazas A
AD  - Division of Endocrinology, Internal Medicine Department, University Hospital "Dr.
      Jose E. Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon,
      Mexico.
FAU - Gonzalez-Gonzalez, Jose Gerardo
AU  - Gonzalez-Gonzalez JG
AD  - Division of Endocrinology, Internal Medicine Department, University Hospital "Dr.
      Jose E. Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon,
      Mexico. Electronic address: [email protected]
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170708
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (Hypoglycemic Agents)
RN  - 9100L32L2N (Metformin)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/drug therapy
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*adverse effects
MH  - Male
MH  - Metformin/*adverse effects/therapeutic use
MH  - Middle Aged
MH  - Vitamin B 12/blood
MH  - Vitamin B 12 Deficiency/blood/*chemically induced
MH  - Young Adult
OTO - NOTNLM
OT  - Cyanocobalamin-deficiency
OT  - Metformin
OT  - Type 2 diabetes
OT  - Vitamin B12 deficiency
EDAT- 2017/09/03 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/09/03 06:00
PHST- 2017/02/07 [received]
PHST- 2017/03/25 [revised]
PHST- 2017/04/17 [accepted]
AID - S0002-9629(17)30220-3 [pii]
AID - 10.1016/j.amjms.2017.04.010 [doi]
PST - ppublish
SO  - Am J Med Sci. 2017 Aug;354(2):165-171. doi: 10.1016/j.amjms.2017.04.010. Epub
      2017 Jul 8.