PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Agrimonia pilosa Ledeb. aqueous extract improves impaired glucose tolerance in high-fat diet-fed rats by decreasing the inflammatory response.

Abstract Agrimonia pilosa Ledeb. is a medicinal plant with physiological activities such as anti-cancer, antioxidant, anti-inflammatory activities and in vitro anti-diabetic activity. However, the effects of aqueous extracts from A. pilosa on insulin-resistant rats have not yet been examined. We investigated the effects of aqueous extract from A. pilosa on impaired glucose metabolism induced by a high-fat diet in rats.
PMID
Related Publications

Evaluation of anti-obesity activities of ethanolic extract of Terminalia paniculata bark on high fat diet-induced obese rats.

Fermented Moringa oleifera Decreases Hepatic Adiposity and Ameliorates Glucose Intolerance in High-Fat Diet-Induced Obese Mice.

Glucan-rich polysaccharides from Pleurotus sajor-caju (Fr.) Singer prevents glucose intolerance, insulin resistance and inflammation in C57BL/6J mice fed a high-fat diet.

Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice.

Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats.

Authors

Mayor MeshTerms
Keywords

Agrimonia Pilosa

Glucose tolerance

High-fat diet

Inflammation

Obesity

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28870184
OWN - NLM
STAT- MEDLINE
DA  - 20170905
DCOM- 20170908
LR  - 20170908
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Sep 05
TI  - Agrimonia pilosa Ledeb. aqueous extract improves impaired glucose tolerance in
      high-fat diet-fed rats by decreasing the inflammatory response.
PG  - 442
LID - 10.1186/s12906-017-1949-z [doi]
AB  - BACKGROUND: Agrimonia pilosa Ledeb. is a medicinal plant with physiological
      activities such as anti-cancer, antioxidant, anti-inflammatory activities and in 
      vitro anti-diabetic activity. However, the effects of aqueous extracts from A.
      pilosa on insulin-resistant rats have not yet been examined. We investigated the 
      effects of aqueous extract from A. pilosa on impaired glucose metabolism induced 
      by a high-fat diet in rats. METHODS: Male Sprague-Dawley rats were assigned to
      the following groups: normal-fat diet (NF, n = 9); high-fat diet (HF, n = 9);
      high-fat diet with 0.1% A. pilosa aqueous extract (HFA, n = 10). Experimental
      diets were administered for 16 weeks. At the end of the treatment, liver and fat 
      tissues were isolated, and serum was collected for biochemical analysis. RESULTS:
      The HF group rats had a significantly higher liver weight than the NF group rats 
      did, and increased hepatic lipid accumulation (p < 0.05); however,
      supplementation with A. pilosa decreased liver weight. Blood glucose levels in
      the HFA group were lower than levels measured in the HF group 30, 60, and 120 min
      after glucose administration (p < 0.05). In addition, dietary A. pilosa
      supplementation decreased tumor necrosis factor alpha and interleukin 6 levels,
      while increasing serum adiponectin concentrations (p < 0.05 vs. the HF group).
      These effects were accompanied by reduced hepatic and adipose tissue expression
      of inflammation-related genes such as Tnf and Il1b (p < 0.05). CONCLUSIONS: Our
      findings indicate that A. pilosa aqueous extract can ameliorate insulin
      resistance in high-fat diet-fed rats by decreasing the inflammatory response.
FAU - Jang, Hwan Hee
AU  - Jang HH
AD  - Functional Food & Nutrition Division, National Institute of Agricultural
      Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.
FAU - Nam, Song Yee
AU  - Nam SY
AD  - Functional Food & Nutrition Division, National Institute of Agricultural
      Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.
FAU - Kim, Mi Ju
AU  - Kim MJ
AD  - Functional Food & Nutrition Division, National Institute of Agricultural
      Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.
FAU - Kim, Jung Bong
AU  - Kim JB
AD  - Functional Food & Nutrition Division, National Institute of Agricultural
      Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.
FAU - Choi, Jeong Sook
AU  - Choi JS
AD  - Functional Food & Nutrition Division, National Institute of Agricultural
      Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.
FAU - Kim, Haeng Ran
AU  - Kim HR
AD  - Functional Food & Nutrition Division, National Institute of Agricultural
      Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.
FAU - Lee, Young Min
AU  - Lee YM
AD  - Division of Applied Food System, Major of Food and Nutrition, Seoul Women's
      University, Seoul, 01797, South Korea. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170905
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Agrimonia/*chemistry
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Glucose Intolerance/*drug therapy/etiology/immunology/metabolism
MH  - Humans
MH  - Insulin/metabolism
MH  - Interleukin-6/genetics/immunology
MH  - Liver/metabolism
MH  - Male
MH  - Obesity/drug therapy/etiology/immunology/metabolism
MH  - Plant Extracts/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/genetics/immunology
PMC - PMC5583762
OTO - NOTNLM
OT  - Agrimonia Pilosa
OT  - Glucose tolerance
OT  - High-fat diet
OT  - Inflammation
OT  - Obesity
EDAT- 2017/09/06 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/09/06 06:00
PHST- 2017/06/23 [received]
PHST- 2017/08/25 [accepted]
AID - 10.1186/s12906-017-1949-z [doi]
AID - 10.1186/s12906-017-1949-z [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Sep 5;17(1):442. doi: 10.1186/s12906-017-1949-z.