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Understanding the effect of corticosteroid pretreatment in brain-dead organ donors: new mechanistic insights for improvement of organ quality in liver transplantation.

Abstract Transplant surgeons are currently faced with the challenge to accept marginal liver transplants due to steatosis or old age. Improving organ quality by implementing a selective organ protective donor management could be the first step towards a graft of enhanced quality. However, the molecular mechanisms of such treatments are still poorly understood. Glucocorticoid medication in donor medicine has been carried out and discussed for a long time. In a recent study published in Clinical Science, Jiménez-Castro et al. [Clin. Sci. (2017) 131, 733-746] demonstrate how liver histology and transplant liver function can be improved by administration of glucocorticoids to brain-dead donor rats with steatotic livers. This work illustrates the need for further trials in order to selectively improve the quality of steatotic livers with a potential for liver transplantation.
PMID
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Authors

Mayor MeshTerms

Brain Death

Tissue Donors

Keywords

brain death

glucocorticoids

hepatic steatosis

liver transplantation

marginal donors

organ donor

Journal Title clinical science (london, england : 1979)
Publication Year Start




PMID- 28870982
OWN - NLM
STAT- MEDLINE
DA  - 20170905
DCOM- 20170912
LR  - 20170912
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Linking)
VI  - 131
IP  - 18
DP  - 2017 Sep 15
TI  - Understanding the effect of corticosteroid pretreatment in brain-dead organ
      donors: new mechanistic insights for improvement of organ quality in liver
      transplantation.
PG  - 2377-2379
LID - 10.1042/CS20170178 [doi]
AB  - Transplant surgeons are currently faced with the challenge to accept marginal
      liver transplants due to steatosis or old age. Improving organ quality by
      implementing a selective organ protective donor management could be the first
      step towards a graft of enhanced quality. However, the molecular mechanisms of
      such treatments are still poorly understood. Glucocorticoid medication in donor
      medicine has been carried out and discussed for a long time. In a recent study
      published in Clinical Science, Jimenez-Castro et al. [Clin. Sci. (2017) 131,
      733-746] demonstrate how liver histology and transplant liver function can be
      improved by administration of glucocorticoids to brain-dead donor rats with
      steatotic livers. This work illustrates the need for further trials in order to
      selectively improve the quality of steatotic livers with a potential for liver
      transplantation.
CI  - (c) 2017 The Author(s). Published by Portland Press Limited on behalf of the
      Biochemical Society.
FAU - Dahrenmoller, Carola
AU  - Dahrenmoller C
AD  - Department of Abdominal Surgery and Transplantation, Cliniques Universitaires
      Saint-Luc, Universite Catholique de Louvain, Brussels 1200, Belgium
      [email protected]
FAU - Reding, Raymond
AU  - Reding R
AD  - Department of Abdominal Surgery and Transplantation, Cliniques Universitaires
      Saint-Luc, Universite Catholique de Louvain, Brussels 1200, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20170903
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - *Brain Death
MH  - Glucocorticoids/pharmacology/*therapeutic use
MH  - Humans
MH  - Liver/*drug effects/pathology
MH  - Liver Transplantation/*methods
MH  - Organ Preservation/methods
MH  - *Tissue Donors
OTO - NOTNLM
OT  - brain death
OT  - glucocorticoids
OT  - hepatic steatosis
OT  - liver transplantation
OT  - marginal donors
OT  - organ donor
EDAT- 2017/09/06 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/09/06 06:00
PHST- 2017/04/18 [received]
PHST- 2017/06/05 [revised]
PHST- 2017/08/02 [accepted]
AID - CS20170178 [pii]
AID - 10.1042/CS20170178 [doi]
PST - epublish
SO  - Clin Sci (Lond). 2017 Sep 3;131(18):2377-2379. doi: 10.1042/CS20170178. Print
      2017 Sep 15.