PubTransformer

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PMID- 28874128
OWN - NLM
STAT- MEDLINE
DA  - 20170906
DCOM- 20170912
LR  - 20170912
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Sep 06
TI  - Relationship of genetic causes and inhibin B in non obstructive azoospermia
      spermatogenic failure.
PG  - 98
LID - 10.1186/s12881-017-0456-x [doi]
AB  - BACKGROUND: Chromosomal disorders in non obstructive azoospermia (NOA) may have
      an important influence on spermatogenesis, which may be reflected by the serum
      inhibin B levels. Till now, few studies have concerned the relationship of
      genetic causes and inhibin B in NOA. METHODS: In this retrospective study, 322
      men with NOA in Center for Reproductive Medicine, Nanfang Hospital, Southern
      Medical University were collected. The level of follicle stimulating hormone
      (FSH), inhibin B, Y chromosome microdeletion test (YCMD) and karyotype were
      measured. RESULTS: Abnormal karyotypes were present in 38.5% of NOA, and YCMD
      were present in 18.0%, there was a high correlation between karyotypes and YCMD
      (chi2 = 11.892, P < 0.001). The level of inhibin B in chromosomal abnormality
      from lowest to highest was 46,XX (or 45,X), 47, XXY, mosaics, polymorphisms,
      inversion and translocation. And the level of inhibin B within Non-AZF a&b region
      deletion was higher than AZF a&b microdeletion. CONCLUSION: According to the
      level of inhibin B, spermatogenesis in chromosomal abnormality from lowest to
      highest was 46,XX (or 45,X), 47, XXY, mosaics, polymorphisms, inversion and
      translocation. And spermatogenesis within Non-AZF a&b region deletion was better 
      than AZF a&b microdeletion.
FAU - Chu, Qing-Jun
AU  - Chu QJ
AD  - Department of Obstetrics and Gynecology, Center for Reproductive Medicine,
      Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical
      University, Guangzhou, 510515, China.
FAU - Hua, Rui
AU  - Hua R
AD  - Department of Obstetrics and Gynecology, Center for Reproductive Medicine,
      Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical
      University, Guangzhou, 510515, China.
FAU - Luo, Chen
AU  - Luo C
AD  - Department of Obstetrics and Gynecology, Center for Reproductive Medicine,
      Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical
      University, Guangzhou, 510515, China.
FAU - Chen, Qing-Jie
AU  - Chen QJ
AD  - Department of Obstetrics and Gynecology, Center for Reproductive Medicine,
      Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical
      University, Guangzhou, 510515, China.
FAU - Wu, Biao
AU  - Wu B
AD  - Department of Obstetrics and Gynecology, Center for Reproductive Medicine,
      Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical
      University, Guangzhou, 510515, China.
FAU - Quan, Song
AU  - Quan S
AD  - Department of Obstetrics and Gynecology, Center for Reproductive Medicine,
      Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical
      University, Guangzhou, 510515, China. [email protected]
FAU - Zhu, Yong-Tong
AU  - Zhu YT
AUID- ORCID: http://orcid.org/0000-0003-4827-9349
AD  - Department of Obstetrics and Gynecology, Center for Reproductive Medicine,
      Nanfang Hospital/ The First School of Clinical Medicine, Southern Medical
      University, Guangzhou, 510515, China. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170906
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - 0 (inhibin B)
RN  - 57285-09-3 (Inhibins)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - Azoospermia, Nonobstructive
SB  - IM
MH  - Adult
MH  - Azoospermia/blood/*genetics
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Y
MH  - Follicle Stimulating Hormone
MH  - Humans
MH  - Inhibins/*blood
MH  - Karyotyping
MH  - Male
MH  - Retrospective Studies
MH  - Sex Chromosome Aberrations
MH  - Spermatogenesis/genetics
PMC - PMC5585947
OTO - NOTNLM
OT  - Inhibin B
OT  - Karyotype
OT  - Non obstruction azoospermia
OT  - Y chromosome microdeletion
EDAT- 2017/09/07 06:00
MHDA- 2017/09/13 06:00
CRDT- 2017/09/07 06:00
PHST- 2017/01/18 [received]
PHST- 2017/08/24 [accepted]
AID - 10.1186/s12881-017-0456-x [doi]
AID - 10.1186/s12881-017-0456-x [pii]
PST - epublish
SO  - BMC Med Genet. 2017 Sep 6;18(1):98. doi: 10.1186/s12881-017-0456-x.