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Prevalence and Natural History of Superficial Siderosis: A Population-Based Study.

Abstract Superficial siderosis (SS) is characterized by hemosiderin deposition in the superficial layers of the central nervous system and can be seen during postmortem examination or with iron-sensitive magnetic resonance imaging techniques. The distribution of SS may predict the probable underlying cause. This study aimed to report the prevalence and natural history of SS in a population-based study.
PMID
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Authors

Mayor MeshTerms
Keywords

cerebral hemorrhage

hemosiderin

magnetic resonance imaging

prevalence

Journal Title stroke
Publication Year Start




PMID- 29070715
OWN - NLM
STAT- MEDLINE
DCOM- 20171219
LR  - 20171219
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 48
IP  - 12
DP  - 2017 Dec
TI  - Prevalence and Natural History of Superficial Siderosis: A Population-Based
      Study.
PG  - 3210-3214
LID - 10.1161/STROKEAHA.117.018974 [doi]
AB  - BACKGROUND AND PURPOSE: Superficial siderosis (SS) is characterized by
      hemosiderin deposition in the superficial layers of the central nervous system
      and can be seen during postmortem examination or with iron-sensitive magnetic
      resonance imaging techniques. The distribution of SS may predict the probable
      underlying cause. This study aimed to report the prevalence and natural history
      of SS in a population-based study. METHODS: Brain magnetic resonance imaging
      scans from the MCSA (Mayo Clinic Study of Aging), a population-based study of
      residents 50 to 89 years of age in Olmsted County, Minnesota, were reviewed.
      Participants with imaging consistent with SS were identified from 2011 through
      2016. An inverse probability weighting approach was used to convert our observed 
      frequencies to population prevalence of SS. Additional data abstracted included
      amyloid positron emission tomography, Apolipoprotein E genotype, coexisting
      cerebral microbleeds, and extent of SS. RESULTS: A total of 1412 participants had
      eligible magnetic resonance imaging scans. Two participants had infratentorial
      SS, restricted to the posterior fossa. Thirteen participants had cortical SS
      involving the cerebral convexities (7 focal and 6 disseminated). Only 3 of the
      participants with cortical SS (23%) also had cerebral microbleeds. The population
      prevalence of SS was 0.21% (95% confidence interval, 0-0.45) in those 50 to 69
      years old and 1.43% (confidence interval, 0.53-2.34) in those over 69 years old. 
      Apolipoprotein E epsilon2 allele was more common in those with SS (57.1% versus
      15.0%; P<0.001). Compared with participants without SS, those with SS were also
      more likely to have a positive amyloid positron emission tomographic scan (76.9% 
      versus 29.8%; P<0.001). CONCLUSIONS: SS may be encountered in the general elderly
      population. The association with increased amyloid burden and Apolipoprotein E
      epsilon2 genotype supports cerebral amyloid angiopathy as the most common
      mechanism. Longitudinal follow-up is needed to evaluate the risk of subsequent
      hemorrhage in cases of incidentally discovered SS.
CI  - (c) 2017 American Heart Association, Inc.
FAU - Pichler, Michael
AU  - Pichler M
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Vemuri, Prashanthi
AU  - Vemuri P
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Rabinstein, Alejandro A
AU  - Rabinstein AA
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Aakre, Jeremiah
AU  - Aakre J
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Flemming, Kelly D
AU  - Flemming KD
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Brown, Robert D Jr
AU  - Brown RD Jr
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Kumar, Neeraj
AU  - Kumar N
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Kantarci, Kejal
AU  - Kantarci K
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Kremers, Walter
AU  - Kremers W
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Mielke, Michelle M
AU  - Mielke MM
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Knopman, David S
AU  - Knopman DS
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Jack, Clifford R Jr
AU  - Jack CR Jr
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Petersen, Ronald C
AU  - Petersen RC
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Lowe, Val
AU  - Lowe V
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN.
FAU - Graff-Radford, Jonathan
AU  - Graff-Radford J
AD  - From the Department of Neurology (M.P., A.A.R., K.D.F., R.D.B., N.K., M.M.M.,
      D.S.K., R.C.P., J.G.-R.), Department of Radiology (P.V., K.K., C.R.J., V.L.), and
      Department of Health Sciences Research (J.A., W.K., M.M.M.), Mayo Clinic,
      Rochester, MN. [email protected]
LA  - eng
GR  - R01 AG041851/AG/NIA NIH HHS/United States
GR  - R01 AG034676/AG/NIA NIH HHS/United States
GR  - P50 AG016574/AG/NIA NIH HHS/United States
GR  - R01 AG011378/AG/NIA NIH HHS/United States
GR  - R01 NS097495/NS/NINDS NIH HHS/United States
GR  - K76 AG057015/AG/NIA NIH HHS/United States
GR  - U01 AG006786/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20171025
PL  - United States
TA  - Stroke
JT  - Stroke
JID - 0235266
RN  - 0 (Amyloid)
RN  - 0 (Apolipoprotein E2)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloid/genetics/metabolism
MH  - Apolipoprotein E2/genetics
MH  - Cerebral Small Vessel Diseases/epidemiology/genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Minnesota/epidemiology
MH  - Population
MH  - Positron-Emission Tomography
MH  - Prevalence
MH  - Risk Factors
MH  - Siderosis/diagnostic imaging/*epidemiology/genetics
PMC - PMC5705336
MID - NIHMS909854
OTO - NOTNLM
OT  - cerebral hemorrhage
OT  - hemosiderin
OT  - magnetic resonance imaging
OT  - prevalence
EDAT- 2017/10/27 06:00
MHDA- 2017/12/20 06:00
CRDT- 2017/10/27 06:00
PMCR- 2018/12/01 00:00
PHST- 2017/08/02 00:00 [received]
PHST- 2017/08/30 00:00 [revised]
PHST- 2017/09/21 00:00 [accepted]
PHST- 2018/12/01 00:00 [pmc-release]
PHST- 2017/10/27 06:00 [pubmed]
PHST- 2017/12/20 06:00 [medline]
PHST- 2017/10/27 06:00 [entrez]
AID - STROKEAHA.117.018974 [pii]
AID - 10.1161/STROKEAHA.117.018974 [doi]
PST - ppublish
SO  - Stroke. 2017 Dec;48(12):3210-3214. doi: 10.1161/STROKEAHA.117.018974. Epub 2017
      Oct 25.