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Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health.

Abstract The incidence of metabolic disorders like type 2 diabetes and obesity continues to increase. In addition to the well-known contributors to these disorders, such as food intake and sedentary lifestyle, recent research in the exposure science discipline provides evidence that exposure to endocrine-disrupting chemicals like bisphenol A and phthalates via multiple routes (e.g., food, drink, skin contact) also contribute to the increased risk of metabolic disorders. Endocrine-disrupting chemicals (EDCs) can disrupt any aspect of hormone action. It is becoming increasingly clear that EDCs not only affect endocrine function but also adversely affect immune system function. In this review, we focus on human, animal, and in vitro studies that demonstrate EDC exposure induces dysfunction of the immune system, which, in turn, has detrimental effects on metabolic health. These findings highlight how the immune system is emerging as a novel player by which EDCs may mediate their effects on metabolic health. We also discuss studies highlighting mechanisms by which EDCs affect the immune system. Finally, we consider that a better understanding of the immunomodulatory roles of EDCs will provide clues to enhance metabolic function and contribute toward the long-term goal of reducing the burden of environmentally induced diabetes and obesity.
PMID
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Authors

Mayor MeshTerms

Global Health

Health Transition

Keywords
Journal Title endocrinology
Publication Year Start




PMID- 29145569
OWN - NLM
STAT- MEDLINE
DCOM- 20180221
LR  - 20180221
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Linking)
VI  - 159
IP  - 1
DP  - 2018 Jan 1
TI  - Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on
      Metabolic Health.
PG  - 32-45
LID - 10.1210/en.2017-00882 [doi]
AB  - The incidence of metabolic disorders like type 2 diabetes and obesity continues
      to increase. In addition to the well-known contributors to these disorders, such 
      as food intake and sedentary lifestyle, recent research in the exposure science
      discipline provides evidence that exposure to endocrine-disrupting chemicals like
      bisphenol A and phthalates via multiple routes (e.g., food, drink, skin contact) 
      also contribute to the increased risk of metabolic disorders.
      Endocrine-disrupting chemicals (EDCs) can disrupt any aspect of hormone action.
      It is becoming increasingly clear that EDCs not only affect endocrine function
      but also adversely affect immune system function. In this review, we focus on
      human, animal, and in vitro studies that demonstrate EDC exposure induces
      dysfunction of the immune system, which, in turn, has detrimental effects on
      metabolic health. These findings highlight how the immune system is emerging as a
      novel player by which EDCs may mediate their effects on metabolic health. We also
      discuss studies highlighting mechanisms by which EDCs affect the immune system.
      Finally, we consider that a better understanding of the immunomodulatory roles of
      EDCs will provide clues to enhance metabolic function and contribute toward the
      long-term goal of reducing the burden of environmentally induced diabetes and
      obesity.
CI  - Copyright (c) 2018 Endocrine Society.
FAU - Bansal, Amita
AU  - Bansal A
AD  - Center for Research on Reproduction and Women's Health, Perelman School of
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Center of Excellence in Environmental Toxicology, Perelman School of Medicine,
      University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Division of Neonatology, Department of Pediatrics, The Children's Hospital of
      Philadelphia, Philadelphia, Pennsylvania.
FAU - Henao-Mejia, Jorge
AU  - Henao-Mejia J
AD  - Division of Neonatology, Department of Pediatrics, The Children's Hospital of
      Philadelphia, Philadelphia, Pennsylvania.
AD  - The Institute for Immunology, Department of Pathology and Laboratory Medicine,
      Perelman School of Medicine, University of Pennsylvania, Philadelphia,
      Pennsylvania.
FAU - Simmons, Rebecca A
AU  - Simmons RA
AD  - Center for Research on Reproduction and Women's Health, Perelman School of
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Center of Excellence in Environmental Toxicology, Perelman School of Medicine,
      University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Division of Neonatology, Department of Pediatrics, The Children's Hospital of
      Philadelphia, Philadelphia, Pennsylvania.
LA  - eng
GR  - R01 HL136572/HL/NHLBI NIH HHS/United States
GR  - R21 AI128060/AI/NIAID NIH HHS/United States
GR  - P30 ES013508/ES/NIEHS NIH HHS/United States
GR  - R01 ES023284/ES/NIEHS NIH HHS/United States
GR  - R21 DK111755/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Endocrine Disruptors)
SB  - AIM
SB  - IM
MH  - Animals
MH  - Endocrine Disruptors/*toxicity
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Illness/*chemically induced/epidemiology/immunology/metabolism
MH  - *Global Health
MH  - *Health Transition
MH  - Humans
MH  - Immune System/*drug effects/immunology/metabolism
MH  - Immune System Diseases/*chemically induced/epidemiology/immunology/metabolism
MH  - Prevalence
PMC - PMC5761609
EDAT- 2017/11/18 06:00
MHDA- 2018/02/22 06:00
CRDT- 2017/11/18 06:00
PMCR- 2019/01/01 00:00
PHST- 2017/09/29 00:00 [received]
PHST- 2017/11/08 00:00 [accepted]
PHST- 2019/01/01 00:00 [pmc-release]
PHST- 2017/11/18 06:00 [pubmed]
PHST- 2018/02/22 06:00 [medline]
PHST- 2017/11/18 06:00 [entrez]
AID - 4621445 [pii]
AID - 10.1210/en.2017-00882 [doi]
PST - ppublish
SO  - Endocrinology. 2018 Jan 1;159(1):32-45. doi: 10.1210/en.2017-00882.