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White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection.

Abstract White adipose tissue bridges body organs and plays a fundamental role in host metabolism. To what extent adipose tissue also contributes to immune surveillance and long-term protective defense remains largely unknown. Here, we have shown that at steady state, white adipose tissue contained abundant memory lymphocyte populations. After infection, white adipose tissue accumulated large numbers of pathogen-specific memory T cells, including tissue-resident cells. Memory T cells in white adipose tissue expressed a distinct metabolic profile, and white adipose tissue from previously infected mice was sufficient to protect uninfected mice from lethal pathogen challenge. Induction of recall responses within white adipose tissue was associated with the collapse of lipid metabolism in favor of antimicrobial responses. Our results suggest that white adipose tissue represents a memory T cell reservoir that provides potent and rapid effector memory responses, positioning this compartment as a potential major contributor to immunological memory.
PMID
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Authors

Mayor MeshTerms
Keywords

T cells

adipocytes

adipose tissue

central memory T cells

effector memory T cells

infection

lipids

memory

metabolism

resident memory T cells

Journal Title immunity
Publication Year Start




PMID- 29221731
OWN - NLM
STAT- Publisher
LR  - 20171211
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
DP  - 2017 Nov 30
TI  - White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective
      Memory Responses to Infection.
LID - S1074-7613(17)30486-7 [pii]
LID - 10.1016/j.immuni.2017.11.009 [doi]
AB  - White adipose tissue bridges body organs and plays a fundamental role in host
      metabolism. To what extent adipose tissue also contributes to immune surveillance
      and long-term protective defense remains largely unknown. Here, we have shown
      that at steady state, white adipose tissue contained abundant memory lymphocyte
      populations. After infection, white adipose tissue accumulated large numbers of
      pathogen-specific memory T cells, including tissue-resident cells. Memory T cells
      in white adipose tissue expressed a distinct metabolic profile, and white adipose
      tissue from previously infected mice was sufficient to protect uninfected mice
      from lethal pathogen challenge. Induction of recall responses within white
      adipose tissue was associated with the collapse of lipid metabolism in favor of
      antimicrobial responses. Our results suggest that white adipose tissue represents
      a memory T cell reservoir that provides potent and rapid effector memory
      responses, positioning this compartment as a potential major contributor to
      immunological memory.
CI  - Published by Elsevier Inc.
FAU - Han, Seong-Ji
AU  - Han SJ
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Glatman Zaretsky, Arielle
AU  - Glatman Zaretsky A
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Andrade-Oliveira, Vinicius
AU  - Andrade-Oliveira V
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Collins, Nicholas
AU  - Collins N
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Dzutsev, Amiran
AU  - Dzutsev A
AD  - Cancer and Inflammation Program, Center for Cancer Research, National Cancer
      Institute, NIH, Bethesda, MD 20892, USA.
FAU - Shaik, Jahangheer
AU  - Shaik J
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Morais da Fonseca, Denise
AU  - Morais da Fonseca D
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; Present
      address: Department of Immunology, Institute of Biomedical Sciences, University
      of Sao Paulo, Sao Paulo, Brazil.
FAU - Harrison, Oliver J
AU  - Harrison OJ
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Tamoutounour, Samira
AU  - Tamoutounour S
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Byrd, Allyson L
AU  - Byrd AL
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; Translational
      and Functional Genomics Branch, National Human Genome Research Institute, NIH,
      Bethesda, MD 20892, USA; Department of Bioinformatics, Boston University, Boston,
      MA 02215, USA.
FAU - Smelkinson, Margery
AU  - Smelkinson M
AD  - Biological Imaging, Research Technology Branch, National Institute of Allergy and
      Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Bouladoux, Nicolas
AU  - Bouladoux N
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; NIAID
      Microbiome Program, NIH, Bethesda, MD 20892, USA.
FAU - Bliska, James B
AU  - Bliska JB
AD  - Department of Molecular Genetics and Microbiology, 238 Centers for Molecular
      Medicine, Stony Brook University, Stonybrook, NY 11794, USA.
FAU - Brenchley, Jason M
AU  - Brenchley JM
AD  - Barrier Immunity Section, Laboratory of Parasitic Diseases, National Institute of
      Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
FAU - Brodsky, Igor E
AU  - Brodsky IE
AD  - Department of Pathobiology, School of Veterinary Medicine, University of
      Pennsylvania, Philadelphia, PA 19104, USA.
FAU - Belkaid, Yasmine
AU  - Belkaid Y
AD  - Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute 
      of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; NIAID
      Microbiome Program, NIH, Bethesda, MD 20892, USA. Electronic address:
      [email protected]
LA  - eng
GR  - R01 AI099222/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20171130
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
OTO - NOTNLM
OT  - T cells
OT  - adipocytes
OT  - adipose tissue
OT  - central memory T cells
OT  - effector memory T cells
OT  - infection
OT  - lipids
OT  - memory
OT  - metabolism
OT  - resident memory T cells
EDAT- 2017/12/10 06:00
MHDA- 2017/12/10 06:00
CRDT- 2017/12/10 06:00
PHST- 2017/02/07 00:00 [received]
PHST- 2017/09/13 00:00 [revised]
PHST- 2017/11/06 00:00 [accepted]
PHST- 2017/12/10 06:00 [entrez]
PHST- 2017/12/10 06:00 [pubmed]
PHST- 2017/12/10 06:00 [medline]
AID - S1074-7613(17)30486-7 [pii]
AID - 10.1016/j.immuni.2017.11.009 [doi]
PST - aheadofprint
SO  - Immunity. 2017 Nov 30. pii: S1074-7613(17)30486-7. doi:
      10.1016/j.immuni.2017.11.009.