Reduction of opioid use and improvement in chronic pain in opioid-experienced patients after topical analgesic treatment: an exploratory analysis.
|Abstract||There is a need to identify safe and effective opioid-sparing multimodal alternative treatment strategies and approaches, including topical analgesics, for opioid-experienced chronic pain patients to mitigate the risk of addiction, misuse, and abuse of opioids.|
Evaluation of Quality of Life, Functioning, Disability, and Work/School Productivity Following Treatment with an Extended-Release Hydrocodone Tablet Formulated with Abuse-Deterrence Technology: A 12-month Open-label Study in Patients with Chronic Pain.
Changes in pain and concurrent pain medication use following compounded topical analgesic treatment for chronic pain: 3- and 6-month follow-up results from the prospective, observational Optimizing Patient Experience and Response to Topical Analgesics study.
|Journal Title||postgraduate medicine|
|Publication Year Start||2018-01-01|
PMID- 29224410 OWN - NLM STAT- MEDLINE DCOM- 20180103 LR - 20180103 IS - 1941-9260 (Electronic) IS - 0032-5481 (Linking) VI - 130 IP - 1 DP - 2018 Jan TI - Reduction of opioid use and improvement in chronic pain in opioid-experienced patients after topical analgesic treatment: an exploratory analysis. PG - 42-51 LID - 10.1080/00325481.2018.1414551 [doi] AB - OBJECTIVE: There is a need to identify safe and effective opioid-sparing multimodal alternative treatment strategies and approaches, including topical analgesics, for opioid-experienced chronic pain patients to mitigate the risk of addiction, misuse, and abuse of opioids. METHODS: This subset analysis from a prospective, observational study evaluated changes in opioid use, other concurrent medication use, and pain severity and interference in opioid-experienced patients (OEP) treated with topical analgesics for chronic pain with measures obtained at baseline and 3- and 6- month follow-up. RESULTS: The 3-month opioid-experienced patient (3-month OEP) group included 121 patients who completed baseline and 3-month follow-up assessments; 27 opioid-experienced patients completed baseline and 6-month follow-up assessments (6-month OEP). Demographic characteristics, and mean pain severity and interference scores were similar between groups at baseline. After treatment with topical analgesics, 49% of patients in the 3-month and 56% of patients in the 6-month group reported they had completely discontinued use of opioids. In addition, 31% of patients at the 3-month assessment and 30% at the 6-month assessment reported that they were no longer taking any pain medication. Other concurrent medications decreased by 65% after 3 months, and 74% after 6 months. There were statistically significant decreases from baseline in pain severity and interference scores within the 3- (CI:0.7-1.4, 1.4-2.2) and 6-month (CI:0.7-2.4 (severity); CI:1.2-3.5 (interference)) OEP groups. CONCLUSIONS: Opioid use and other concurrent medications decreased among opioid-experienced chronic pain patients after 3- and 6- months of treatment with topical analgesics. Pain severity and interference scores also decreased. The topical analgesics were reported to be effective and safe for the treatment of chronic pain, with randomized controlled trials needed to confirm these findings. FAU - Gudin, Jeffrey A AU - Gudin JA AD - a Englewood Hospital and Medical Center , Englewood , NJ , USA. FAU - Brennan, Michael J AU - Brennan MJ AD - b The Pain Center of Fairfield , Fairfield , CT , USA. FAU - Harris, E Dennis AU - Harris ED AD - c Clarity Science , Austin , TX , USA. FAU - Hurwitz, Peter L AU - Hurwitz PL AD - c Clarity Science , Austin , TX , USA. FAU - Dietze, Derek T AU - Dietze DT AD - d Metrics for Learning , LLC , Queen Creek , AZ , USA. FAU - Strader, James D AU - Strader JD AD - e Safe Harbor Compliance and Clinical Services , LLC , Austin , TX , USA. LA - eng PT - Journal Article PT - Observational Study PL - England TA - Postgrad Med JT - Postgraduate medicine JID - 0401147 RN - 0 (Analgesics, Opioid) SB - AIM SB - IM MH - Administration, Topical MH - Adolescent MH - Adult MH - Analgesics, Opioid/*therapeutic use MH - Chronic Pain/diagnosis/*drug therapy/etiology MH - Combined Modality Therapy MH - Drug Administration Schedule MH - Female MH - Humans MH - Male MH - Middle Aged MH - Opioid-Related Disorders/*prevention & control MH - Pain Measurement MH - Patient Satisfaction MH - Prospective Studies MH - Self Report MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - Chronic pain OT - opioid epidemic OT - opioid-experienced OT - opioids OT - pain interference OT - pain severity OT - topical analgesics EDAT- 2017/12/12 06:00 MHDA- 2018/01/04 06:00 CRDT- 2017/12/12 06:00 PHST- 2017/12/12 06:00 [pubmed] PHST- 2018/01/04 06:00 [medline] PHST- 2017/12/12 06:00 [entrez] AID - 10.1080/00325481.2018.1414551 [doi] PST - ppublish SO - Postgrad Med. 2018 Jan;130(1):42-51. doi: 10.1080/00325481.2018.1414551.